SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ak5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.23A 1jffB-3ak5A:
undetectable		 1jffB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 11 GLN A 118
GLY A 398
GLY A 400
LEU A 162
LEU A 352
 None
 1.11A 1jg3A-3ak5A:
undetectable		 1jg3A-3ak5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 11 GLN A 118
GLY A 398
GLY A 400
LEU A 162
LEU A 352
 None
 1.12A 1jg3B-3ak5A:
undetectable		 1jg3B-3ak5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 ILE A 300
GLY A 175
VAL A 171
ALA A 178
GLY A 277
 None
 1.22A 1kiaB-3ak5A:
undetectable		 1kiaB-3ak5A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 ARG A 192
ASP A 106
ASN A 131
 None
 0.89A 1nbhA-3ak5A:
undetectable		 1nbhA-3ak5A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 ARG A 192
ASP A 106
ASN A 131
 None
 0.90A 1nbhD-3ak5A:
undetectable		 1nbhD-3ak5A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 PRO A 879
GLY A 878
ASN A 846
ASP A 940
ARG A 922
 None
 1.42A 2b9eA-3ak5A:
undetectable		 2b9eA-3ak5A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 ALA A 516
ASP A 513
GLY A 515
GLY A 494
ALA A 512
 None
 0.82A 2c49A-3ak5A:
undetectable		 2c49A-3ak5A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.23A 2hxfB-3ak5A:
undetectable		 2hxfB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.23A 2hxhB-3ak5A:
undetectable		 2hxhB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.23A 2p4nB-3ak5A:
undetectable		 2p4nB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 8 VAL A 431
THR A 430
VAL A 403
ILE A 401
 None
 0.90A 2qbmA-3ak5A:
undetectable		 2qbmA-3ak5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 LEU A 275
ILE A 295
ALA A 104
PHE A 154
HIS A 155
 None
 1.06A 2qo4A-3ak5A:
undetectable		 2qo4A-3ak5A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 LEU A 275
ILE A 295
ALA A 104
PHE A 154
HIS A 155
 None
 1.06A 2qo6A-3ak5A:
undetectable		 2qo6A-3ak5A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 THR A 474
PRO A 473
GLY A 446
LEU A 450
 None
 1.02A 2vl2B-3ak5A:
undetectable		 2vl2B-3ak5A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.23A 2wbeB-3ak5A:
undetectable		 2wbeB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 GLY A 398
GLY A 400
LEU A 162
LEU A 352
ASN A 353
 None
None
None
None
CA  A1200 ( 4.6A)
 1.14A 2zw9B-3ak5A:
undetectable		 2zw9B-3ak5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 ILE A 424
LEU A 162
ARG A 493
LEU A 114
 None
 0.88A 3ablA-3ak5A:
undetectable
3ablJ-3ak5A:
undetectable		 3ablA-3ak5A:
20.80
3ablJ-3ak5A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 8 ILE A 424
LEU A 162
ARG A 493
LEU A 114
 None
 0.91A 3ablN-3ak5A:
undetectable
3ablW-3ak5A:
undetectable		 3ablN-3ak5A:
20.80
3ablW-3ak5A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 ILE A 644
PHE A 702
ARG A 698
MET A 638
 None
 1.01A 3ag4N-3ak5A:
undetectable
3ag4W-3ak5A:
undetectable		 3ag4N-3ak5A:
20.80
3ag4W-3ak5A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 ASP A 861
SER A 847
GLU A 851
ASP A 850
 None
 1.23A 3bc9A-3ak5A:
undetectable		 3bc9A-3ak5A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 SER A 238
GLY A 254
GLY A 282
 None
 0.41A 3bogA-3ak5A:
undetectable
3bogC-3ak5A:
undetectable		 3bogA-3ak5A:
undetectable
3bogC-3ak5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 4 GLY A 378
GLY A 355
GLY A 346
GLY A 376
 None
 0.61A 3bogC-3ak5A:
undetectable		 3bogC-3ak5A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 GLY A 415
GLY A 418
GLY A 439
 None
 0.35A 3bogC-3ak5A:
undetectable		 3bogC-3ak5A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 4 GLY A 378
GLY A 355
GLY A 346
GLY A 376
 None
 0.68A 3bogD-3ak5A:
undetectable		 3bogD-3ak5A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.23A 3dcoB-3ak5A:
undetectable		 3dcoB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.21A 3edlB-3ak5A:
undetectable		 3edlB-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 SER A 259
VAL A 278
ASN A 126
VAL A 123
HIS A 125
 None
 1.46A 3g0bA-3ak5A:
undetectable		 3g0bA-3ak5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 SER A 259
VAL A 278
ASN A 126
VAL A 123
HIS A 125
 None
 1.45A 3g0bB-3ak5A:
undetectable		 3g0bB-3ak5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 SER A 259
VAL A 278
ASN A 126
VAL A 123
HIS A 125
 None
 1.41A 3g0bC-3ak5A:
undetectable		 3g0bC-3ak5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 SER A 259
VAL A 278
ASN A 126
VAL A 123
HIS A 125
 None
 1.42A 3g0bD-3ak5A:
undetectable		 3g0bD-3ak5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 615
ASP A 744
THR A 688
LEU A 613
GLY A 640
 None
 1.35A 3g1uB-3ak5A:
undetectable		 3g1uB-3ak5A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 LEU A 335
GLN A 412
VAL A 373
LEU A 380
ILE A 401
 None
 1.07A 3gwxB-3ak5A:
undetectable		 3gwxB-3ak5A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 488
LEU A 622
PHE A 614
LEU A 618
GLY A 495
 None
 1.22A 3iz0B-3ak5A:
undetectable		 3iz0B-3ak5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 11 ALA A 112
LEU A 275
VAL A 278
ILE A 300
PHE A 154
 None
 1.27A 3jw5A-3ak5A:
undetectable		 3jw5A-3ak5A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.74A 3keeB-3ak5A:
7.2		 3keeB-3ak5A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.75A 3keeC-3ak5A:
7.2		 3keeC-3ak5A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.76A 3keeD-3ak5A:
7.2		 3keeD-3ak5A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 PRO A 157
SER A 122
ASN A 148
 None
 0.80A 3lslG-3ak5A:
undetectable		 3lslG-3ak5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 6 PHE A 102
VAL A 189
THR A 221
PHE A  67
 None
 1.12A 3ltwA-3ak5A:
undetectable		 3ltwA-3ak5A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 615
ASP A 744
THR A 688
LEU A 613
GLY A 640
 None
 1.35A 3n58C-3ak5A:
undetectable		 3n58C-3ak5A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 8 SER A 259
VAL A 111
ARG A 146
VAL A 123
 None
 0.83A 3nlrA-3ak5A:
undetectable
3nlrB-3ak5A:
undetectable		 3nlrA-3ak5A:
19.11
3nlrB-3ak5A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_2
(PROTEASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		6 / 9 GLY A 248
ALA A 249
ILE A  81
GLY A 220
ILE A 252
ILE A  83
 None
 1.43A 3nu4B-3ak5A:
undetectable		 3nu4B-3ak5A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 LEU A 907
SER A 904
LEU A 857
PRO A 858
 None
 1.29A 3onnA-3ak5A:
undetectable		 3onnA-3ak5A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 THR A 941
SER A 881
ILE A 924
LEU A 857
LEU A 907
 None
 1.12A 3q87B-3ak5A:
undetectable		 3q87B-3ak5A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 8 GLU A 165
TYR A 141
LEU A 159
PHE A 134
 None
 1.14A 3rqwC-3ak5A:
undetectable
3rqwD-3ak5A:
undetectable		 3rqwC-3ak5A:
16.70
3rqwD-3ak5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 8 GLU A 165
TYR A 141
LEU A 159
PHE A 134
 None
 1.15A 3rqwF-3ak5A:
undetectable
3rqwJ-3ak5A:
undetectable		 3rqwF-3ak5A:
16.70
3rqwJ-3ak5A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.76A 3sueA-3ak5A:
6.8		 3sueA-3ak5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.76A 3sueC-3ak5A:
6.5		 3sueC-3ak5A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 123
HIS A 125
ASP A 153
GLY A 257
ALA A 281
 None
 0.63A 3sufB-3ak5A:
6.8		 3sufB-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 123
HIS A 125
ASP A 153
GLY A 257
SER A 259
 None
 0.78A 3sufB-3ak5A:
6.8		 3sufB-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 11 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.77A 3sufC-3ak5A:
6.5		 3sufC-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 VAL A 123
HIS A 125
ASP A 153
GLY A 257
ALA A 281
 None
 0.55A 3sufD-3ak5A:
6.8		 3sufD-3ak5A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 10 PHE A 304
LEU A 159
VAL A 132
PHE A 134
VAL A 163
 None
 1.47A 3u9fE-3ak5A:
undetectable		 3u9fE-3ak5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 10 PHE A 304
LEU A 159
VAL A 132
PHE A 134
VAL A 163
 None
 1.48A 3u9fI-3ak5A:
undetectable		 3u9fI-3ak5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 11 PHE A 304
LEU A 159
VAL A 132
PHE A 134
VAL A 163
 None
 1.48A 3u9fN-3ak5A:
undetectable
3u9fO-3ak5A:
undetectable		 3u9fN-3ak5A:
12.38
3u9fO-3ak5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 LEU A 705
ALA A 726
VAL A 797
ILE A 724
 None
 0.89A 3wsjB-3ak5A:
undetectable		 3wsjB-3ak5A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 LEU A 856
GLU A 902
SER A 904
 None
 0.80A 4ccqA-3ak5A:
undetectable		 4ccqA-3ak5A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 GLY A  53
THR A 218
LEU A 217
SER A 261
VAL A 105
 None
 1.21A 4f84A-3ak5A:
undetectable		 4f84A-3ak5A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 HIS A 125
TYR A 214
GLY A 257
SER A 259
 None
 1.06A 4fu8A-3ak5A:
13.9		 4fu8A-3ak5A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 LEU A 774
VAL A 772
ALA A 804
LEU A 655
THR A 732
 None
 1.37A 4iaqA-3ak5A:
undetectable		 4iaqA-3ak5A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 LEU A 774
VAL A 772
ALA A 804
LEU A 655
THR A 732
 None
 1.38A 4iarA-3ak5A:
undetectable		 4iarA-3ak5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 11 GLY A 491
GLY A 494
GLY A 495
ALA A 512
GLN A 617
 None
 1.00A 4l8fB-3ak5A:
undetectable		 4l8fB-3ak5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 ASP A 744
ASP A 639
ASN A 717
 None
 0.85A 4q5mA-3ak5A:
undetectable		 4q5mA-3ak5A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 GLU A 165
TYR A 141
LEU A 159
PHE A 134
 None
 1.14A 4twdF-3ak5A:
undetectable
4twdJ-3ak5A:
undetectable		 4twdF-3ak5A:
15.25
4twdJ-3ak5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 6 GLU A 165
TYR A 141
LEU A 159
PHE A 134
 None
 1.18A 4twdI-3ak5A:
undetectable
4twdJ-3ak5A:
undetectable		 4twdI-3ak5A:
15.25
4twdJ-3ak5A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 ASN A 846
PHE A 830
TYR A 862
 None
 0.85A 4u15A-3ak5A:
undetectable		 4u15A-3ak5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 ARG A 922
GLY A 899
GLY A 878
PRO A 879
 None
 0.87A 4u9uA-3ak5A:
2.0		 4u9uA-3ak5A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 ARG A 922
GLY A 899
GLY A 878
PRO A 879
 None
 0.96A 4u9uB-3ak5A:
undetectable		 4u9uB-3ak5A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 6 SER A 778
GLY A 734
ASP A 784
GLY A 713
 None
 0.94A 5cdnC-3ak5A:
undetectable
5cdnD-3ak5A:
undetectable		 5cdnC-3ak5A:
19.77
5cdnD-3ak5A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 6 SER A 778
GLY A 734
ASP A 784
GLY A 713
 None
 0.93A 5cdnT-3ak5A:
undetectable
5cdnU-3ak5A:
undetectable		 5cdnT-3ak5A:
19.77
5cdnU-3ak5A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 PHE A 712
ILE A 724
ASP A 775
 None
 0.73A 5cswA-3ak5A:
undetectable		 5cswA-3ak5A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 7 GLY A 257
SER A 261
ARG A 192
GLY A 194
ALA A 256
 None
 1.35A 5e26C-3ak5A:
undetectable
5e26D-3ak5A:
undetectable		 5e26C-3ak5A:
18.62
5e26D-3ak5A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 PRO A 661
LEU A 752
SER A 689
 None
 0.74A 5fsaB-3ak5A:
undetectable		 5fsaB-3ak5A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 VAL A 373
SER A 374
TRP A 396
 None
 1.02A 5jwaA-3ak5A:
undetectable		 5jwaA-3ak5A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 GLY A 257
SER A 261
ARG A 192
GLY A 194
 None
 0.94A 5kprA-3ak5A:
undetectable		 5kprA-3ak5A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 6 ARG A 158
ASN A 147
ASN A 116
GLN A 118
 None
CA  A1200 (-3.1A)
None
None
 1.18A 5l6eA-3ak5A:
undetectable		 5l6eA-3ak5A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 HIS A 660
ASP A 639
HIS A 615
 None
 0.78A 5oexA-3ak5A:
undetectable		 5oexA-3ak5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 HIS A 660
ASP A 639
HIS A 615
 None
 0.75A 5oexB-3ak5A:
undetectable		 5oexB-3ak5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 HIS A 660
ASP A 639
HIS A 615
 None
 0.77A 5oexC-3ak5A:
undetectable		 5oexC-3ak5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		3 / 3 HIS A 660
ASP A 639
HIS A 615
 None
 0.77A 5oexD-3ak5A:
undetectable		 5oexD-3ak5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 ASP A 258
GLY A 254
ASN A 290
ALA A 213
ASP A 202
 None
 0.93A 5x66A-3ak5A:
undetectable
5x66B-3ak5A:
undetectable		 5x66A-3ak5A:
13.37
5x66B-3ak5A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 ILE A 424
LEU A 162
ARG A 493
LEU A 114
 None
 0.95A 5xdxA-3ak5A:
undetectable
5xdxJ-3ak5A:
undetectable		 5xdxA-3ak5A:
20.80
5xdxJ-3ak5A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 8 LEU A 883
LEU A 806
ALA A 826
LEU A 843
 None
 0.82A 5y7pC-3ak5A:
undetectable		 5y7pC-3ak5A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 HIS A 125
ALA A 281
SER A 259
GLY A 260
 None
 1.12A 5yodB-3ak5A:
3.6		 5yodB-3ak5A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 HIS A 125
SER A 259
GLY A 257
TYR A 214
 None
 1.32A 5yodH-3ak5A:
5.9		 5yodH-3ak5A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 12 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.71A 6c2mC-3ak5A:
6.8		 6c2mC-3ak5A:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 5 GLN A 198
THR A 197
HIS A 125
GLY A 194
 None
 1.17A 6gbnC-3ak5A:
undetectable		 6gbnC-3ak5A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		5 / 11 THR A 722
ASN A 721
PHE A 768
VAL A 772
PHE A 712
 None
 1.49A 6hcoA-3ak5A:
undetectable
6hcoB-3ak5A:
undetectable		 6hcoA-3ak5A:
22.74
6hcoB-3ak5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 ILE A 424
LEU A 162
ARG A 493
LEU A 114
 None
 0.96A 6nmfA-3ak5A:
undetectable
6nmfJ-3ak5A:
undetectable		 6nmfA-3ak5A:
20.80
6nmfJ-3ak5A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP
(Escherichia
coli) 		4 / 7 ILE A 424
LEU A 162
ARG A 493
LEU A 114
 None
 0.94A 6nmpA-3ak5A:
undetectable
6nmpJ-3ak5A:
undetectable		 6nmpA-3ak5A:
20.80
6nmpJ-3ak5A:
5.17