SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3akk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3akk CTKA
(Helicobacter
pylori) 		4 / 8 TYR A 225
GLY A 152
VAL A  64
PHE A 145
 None
 0.91A 1gsfA-3akkA:
undetectable		 1gsfA-3akkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3akk CTKA
(Helicobacter
pylori) 		4 / 8 TYR A 225
GLY A 152
VAL A  64
PHE A 145
 None
 0.91A 1gsfB-3akkA:
undetectable		 1gsfB-3akkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3akk CTKA
(Helicobacter
pylori) 		4 / 8 TYR A 225
GLY A 152
VAL A  64
PHE A 145
 None
 0.91A 1gsfC-3akkA:
undetectable		 1gsfC-3akkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3akk CTKA
(Helicobacter
pylori) 		4 / 8 TYR A 225
GLY A 152
VAL A  64
PHE A 145
 None
 0.91A 1gsfD-3akkA:
undetectable		 1gsfD-3akkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 3akk CTKA
(Helicobacter
pylori) 		4 / 6 PHE A 100
ILE A 132
ALA A 125
MET A 107
 None
 1.19A 1hk2A-3akkA:
undetectable		 1hk2A-3akkA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3akk CTKA
(Helicobacter
pylori) 		3 / 3 ASP A  99
HIS A 157
ASP A 179
 None
None
ADP  A 500 ( 3.1A)
 0.73A 1nw5A-3akkA:
undetectable		 1nw5A-3akkA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 GLY A  19
ASP A 155
ILE A 214
LEU A 215
LEU A 101
 ADP  A 500 (-3.3A)
None
None
None
None
 0.94A 1r30A-3akkA:
undetectable		 1r30A-3akkA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3akk CTKA
(Helicobacter
pylori) 		4 / 6 THR A  74
GLU A  57
PHE A 178
ILE A 177
 None
None
ADP  A 500 ( 4.5A)
None
 1.41A 2w98B-3akkA:
undetectable		 2w98B-3akkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3akk CTKA
(Helicobacter
pylori) 		4 / 6 ILE A 283
ARG A 278
LEU A 275
LEU A 151
 None
 0.79A 3kp6A-3akkA:
undetectable
3kp6B-3akkA:
undetectable		 3kp6A-3akkA:
20.73
3kp6B-3akkA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 PHE A 145
PHE A 140
ILE A 282
ILE A  63
ALA A  60
 None
 1.03A 3nxuB-3akkA:
undetectable		 3nxuB-3akkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 PHE A 140
ARG A 156
ILE A 223
PHE A 141
ALA A 240
 None
 1.35A 3ua1A-3akkA:
undetectable		 3ua1A-3akkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3akk CTKA
(Helicobacter
pylori) 		5 / 9 LEU A 150
ILE A 207
ARG A 206
LEU A 203
ILE A 282
 None
 1.02A 4kukA-3akkA:
undetectable		 4kukA-3akkA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3akk CTKA
(Helicobacter
pylori) 		3 / 3 LYS A 279
ASN A 204
ASP A 284
 None
 0.85A 4o1eA-3akkA:
undetectable		 4o1eA-3akkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 ALA A 188
ASN A  52
PRO A 186
SER A  56
ASP A 190
 None
 1.46A 4xqeA-3akkA:
undetectable		 4xqeA-3akkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 ALA A 188
ASN A  52
PRO A 186
SER A  56
ASP A 190
 None
 1.45A 4xqeB-3akkA:
undetectable		 4xqeB-3akkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 ASN A  52
PRO A 186
VAL A  59
SER A  56
ASP A 190
 None
 1.31A 4xrgA-3akkA:
undetectable		 4xrgA-3akkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 ALA A 188
ASN A  52
PRO A 186
SER A  56
ASP A 190
 None
 1.47A 4xrgB-3akkA:
undetectable		 4xrgB-3akkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3akk CTKA
(Helicobacter
pylori) 		5 / 12 PHE A 145
PHE A 140
ILE A 282
ILE A  63
ALA A  60
 None
 1.13A 5vc0A-3akkA:
undetectable		 5vc0A-3akkA:
23.31