SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ako'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 11 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.40A 1dhiB-3akoA:
undetectable		 1dhiB-3akoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.43A 1dyiA-3akoA:
undetectable		 1dyiA-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.44A 1rb2A-3akoA:
undetectable		 1rb2A-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 10 HIS B 181
LEU A  53
LEU A  64
THR A  62
THR A  63
 None
None
CR2  A  66 ( 4.4A)
CR2  A  66 ( 4.5A)
None
 1.43A 1rj6B-3akoB:
undetectable		 1rj6B-3akoB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.34A 1rx7A-3akoA:
undetectable		 1rx7A-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.39A 1rx8A-3akoA:
undetectable		 1rx8A-3akoA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3ako VENUS
VENUS
(Plant
transformation
vector
pSITEII-4C1;
Plant
transformation
vector
pSITEII-4C1) 		3 / 3 ASN B 170
LEU A 141
HIS B 169
 None
 0.79A 2q6fB-3akoB:
undetectable		 2q6fB-3akoB:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.17A 3t3rB-3akoA:
undetectable		 3t3rB-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.20A 3t3rC-3akoA:
undetectable		 3t3rC-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CR2  A  66 ( 3.6A)
None
None
 1.15A 3t3rD-3akoA:
undetectable		 3t3rD-3akoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		4 / 7 ASP A  19
THR A 108
SER A  28
PHE A  27
 None
 1.06A 4ac9C-3akoA:
undetectable		 4ac9C-3akoA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		3 / 3 VAL A  22
GLY A  24
LYS A  26
 None
 0.74A 4k50A-3akoA:
undetectable		 4k50A-3akoA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		3 / 3 VAL A  22
GLY A  24
LYS A  26
 None
 0.75A 4k50E-3akoA:
undetectable		 4k50E-3akoA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		3 / 3 VAL A  22
GLY A  24
LYS A  26
 None
 0.74A 4k50I-3akoA:
undetectable		 4k50I-3akoA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE B 165
 None
None
None
CR2  A  66 ( 4.5A)
 0.94A 4o1zA-3akoA:
undetectable		 4o1zA-3akoA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.49A 4qi9A-3akoA:
undetectable		 4qi9A-3akoA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		6 / 12 ALA A 110
LEU A  64
ILE A  14
LEU A  42
TYR A  92
THR A 108
 None
CR2  A  66 ( 4.4A)
None
None
None
None
 1.39A 4qlgA-3akoA:
undetectable		 4qlgA-3akoA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 3ako VENUS
(Plant
transformation
vector
pSITEII-4C1) 		5 / 12 HIS A 148
ILE B 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 3.8A)
None
None
None
CR2  A  66 ( 4.5A)
 1.22A 6bbsA-3akoA:
undetectable		 6bbsA-3akoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3ako VENUS
VENUS
(Plant
transformation
vector
pSITEII-4C1;
Plant
transformation
vector
pSITEII-4C1) 		4 / 8 ILE A 136
GLN B 177
THR A  97
TYR B 182
 None
 0.88A 6cduD-3akoA:
undetectable
6cduE-3akoA:
undetectable		 6cduD-3akoA:
19.40
6cduE-3akoA:
19.40