SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3akz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		5 / 12 MET B 278
LEU B 281
LEU B 284
GLY B 285
ILE B 296
 None
None
C  F  12 ( 4.7A)
U  F  13 ( 4.6A)
None
 0.85A 1p93A-3akzB:
undetectable		 1p93A-3akzB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		4 / 7 PHE B  47
MET B  50
PHE B 303
ILE B 244
 None
 0.89A 2zseA-3akzB:
undetectable		 2zseA-3akzB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		5 / 12 ILE B 365
THR B 453
VAL B 444
LEU B 433
THR B 429
 None
 1.19A 3em0B-3akzB:
undetectable		 3em0B-3akzB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		4 / 6 PHE B 315
TYR B 317
HIS B 266
THR B 262
 None
 1.15A 3lb3A-3akzB:
undetectable		 3lb3A-3akzB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		3 / 3 ARG B  70
ASP B 219
GLN B 227
 C  F  75 ( 3.5A)
GSU  B1001 (-4.0A)
None
 0.91A 3lcvB-3akzB:
undetectable		 3lcvB-3akzB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		4 / 5 LEU B 474
ILE B 465
ALA B 411
PHE B 415
 C  G  56 ( 4.3A)
None
None
None
 1.00A 4dc3B-3akzB:
undetectable		 4dc3B-3akzB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		3 / 3 LYS B 455
THR B 458
ILE B 365
 None
U  F  35 ( 4.9A)
None
 0.79A 4e0fB-3akzB:
undetectable		 4e0fB-3akzB:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		4 / 5 ILE B  63
LEU B  61
GLU B  64
VAL B 214
 None
None
GSU  B1001 (-3.8A)
None
 1.00A 4nkxB-3akzB:
undetectable		 4nkxB-3akzB:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		4 / 4 LEU B 228
ILE B 230
ARG B 216
TYR B 231
 None
None
GSU  B1001 (-4.0A)
None
 1.12A 4zzcA-3akzB:
undetectable		 4zzcA-3akzB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		3 / 3 GLU B 339
TRP B 343
ASN B 324
 None
 1.04A 5dv4A-3akzB:
undetectable		 5dv4A-3akzB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		5 / 12 HIS B  38
GLY B  40
GLY B 217
ASP B 219
LEU B 255
 GSU  B1001 ( 4.8A)
GSU  B1001 (-3.7A)
GSU  B1001 (-3.0A)
GSU  B1001 (-4.0A)
GSU  B1001 (-4.5A)
 0.83A 5hg0A-3akzB:
7.3		 5hg0A-3akzB:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3akz GLUTAMYL-TRNA
SYNTHETASE 2
(Thermotoga
maritima) 		5 / 12 HIS B  38
GLY B  40
GLY B 217
ASP B 219
LEU B 255
 GSU  B1001 ( 4.8A)
GSU  B1001 (-3.7A)
GSU  B1001 (-3.0A)
GSU  B1001 (-4.0A)
GSU  B1001 (-4.5A)
 0.82A 5hg0B-3akzB:
7.4		 5hg0B-3akzB:
21.44