SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3al0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 6 LEU A 272
ILE A 456
GLU A 457
PRO A 461
 None
 1.06A 1ditH-3al0A:
undetectable
1ditP-3al0A:
undetectable		 1ditH-3al0A:
17.90
1ditP-3al0A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 SER A  18
GLU A  19
GLU A  20
 None
 0.61A 1eqbD-3al0A:
undetectable		 1eqbD-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 SER A  18
GLU A  19
GLU A  20
 None
 0.61A 1eqbB-3al0A:
undetectable		 1eqbB-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 7 THR A 388
VAL A 175
GLY A 177
ILE A 203
 None
 0.79A 1gtnC-3al0A:
undetectable
1gtnD-3al0A:
undetectable		 1gtnC-3al0A:
9.89
1gtnD-3al0A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY A 152
ALA A 151
GLY A 174
THR A 128
VAL A  40
 None
 0.90A 1k6cB-3al0A:
undetectable		 1k6cB-3al0A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 5 ARG A 309
ASP A 224
SER A 186
SER A 195
 None
 1.48A 1kiaB-3al0A:
undetectable		 1kiaB-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 6 ARG A 309
ASP A 224
SER A 186
SER A 195
 None
 1.46A 1kiaC-3al0A:
undetectable		 1kiaC-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima;
Thermotoga
maritima) 		5 / 12 TYR A 188
LEU B  49
ALA A 192
THR A  76
TYR A  86
 None
 1.15A 1mx8A-3al0A:
undetectable		 1mx8A-3al0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ILE A 456
GLY A 436
VAL A 425
SER A 430
TRP A 132
 None
 1.37A 1nbhA-3al0A:
undetectable		 1nbhA-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ILE A 456
GLY A 436
VAL A 425
SER A 430
TRP A 132
 None
 1.38A 1nbhD-3al0A:
undetectable		 1nbhD-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ASP A 209
THR A  32
GLY A 152
VAL A 473
ALA A 156
 None
 1.22A 1nw5A-3al0A:
undetectable		 1nw5A-3al0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 12 ILE B 396
PHE B 397
ALA B 393
LEU B 371
PHE B 376
 None
 0.89A 1og5B-3al0B:
undetectable		 1og5B-3al0B:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 ASP A 112
GLY A 117
GLY A 140
GLY A 139
 None
 0.64A 1qzzA-3al0A:
undetectable		 1qzzA-3al0A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 GLY A 219
ASP A 221
ILE A 200
ILE A 216
PRO A 202
 None
 1.04A 1sguB-3al0A:
undetectable		 1sguB-3al0A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 4 SER B 166
ILE B 164
VAL B 227
THR B 262
 None
 1.23A 1u70A-3al0B:
undetectable		 1u70A-3al0B:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ALA A 453
ILE A 456
ILE A 423
VAL A 176
ALA A 170
 None
 1.04A 1uduB-3al0A:
undetectable		 1uduB-3al0A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 4 LEU B 177
PRO B 162
ILE B 119
LEU B 106
 None
 1.06A 1ya4B-3al0B:
undetectable		 1ya4B-3al0B:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 4 LEU B 177
PRO B 162
ILE B 119
LEU B 106
 None
 1.03A 1ya4C-3al0B:
undetectable		 1ya4C-3al0B:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 GLY C 191
CYH C 190
LEU C 141
LEU C 385
TYR C 450
 None
 1.23A 1zgyA-3al0C:
undetectable		 1zgyA-3al0C:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 LEU A  70
ALA A 192
ARG B  79
CYH A  78
THR A  76
 None
 1.38A 2aa5B-3al0A:
undetectable		 2aa5B-3al0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		6 / 12 ILE B  11
GLN B  14
LEU B 155
ILE B 156
LEU B 196
ALA B 195
 None
 1.19A 2aclG-3al0B:
undetectable		 2aclG-3al0B:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 LEU C 440
LEU C 477
GLY C 429
ARG C 471
ASN C 428
 None
 1.30A 2bm9B-3al0C:
undetectable		 2bm9B-3al0C:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 12 LEU B 231
ALA B 170
ILE B 164
HIS B  12
LEU B 196
 None
 1.14A 2jn3A-3al0B:
undetectable		 2jn3A-3al0B:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 7 VAL A  40
ALA A 151
PHE A 126
PRO A 127
THR A 120
 None
 1.20A 2q6oA-3al0A:
undetectable		 2q6oA-3al0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 6 VAL A  40
PHE A 126
PRO A 127
THR A 120
 None
 1.25A 2q6oB-3al0A:
undetectable		 2q6oB-3al0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		3 / 3 ASN C 152
ARG C 132
ASP C 323
 None
GSU  C1001 (-2.2A)
GSU  C1001 (-3.0A)
 0.95A 2qe6A-3al0C:
undetectable		 2qe6A-3al0C:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		3 / 3 ASN C 152
ARG C 132
ASP C 323
 None
GSU  C1001 (-2.2A)
GSU  C1001 (-3.0A)
 0.93A 2qe6B-3al0C:
undetectable		 2qe6B-3al0C:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 8 VAL C 344
PRO C 343
VAL C 131
GLU C 127
 None
 1.00A 2v32C-3al0C:
undetectable
2v32D-3al0C:
undetectable		 2v32C-3al0C:
17.20
2v32D-3al0C:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 10 LEU A 172
VAL A 435
GLY A 436
GLY A 139
SER A 118
 None
 0.93A 2v3kA-3al0A:
undetectable		 2v3kA-3al0A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 8 LEU C 141
LEU C 381
LEU C 192
ARG C 372
 None
 1.06A 2xn3A-3al0C:
undetectable
2xn3B-3al0C:
undetectable		 2xn3A-3al0C:
20.47
2xn3B-3al0C:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima;
Thermotoga
maritima) 		4 / 5 ILE B  93
PHE B 277
VAL A 340
PHE B  83
 None
 1.07A 2ygnA-3al0B:
undetectable		 2ygnA-3al0B:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		3 / 3 MET B 148
GLU B 126
ASP B 281
 None
 0.80A 3a25A-3al0B:
undetectable		 3a25A-3al0B:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 11 THR C 562
LEU C 572
LEU C 565
ILE C 569
LEU C 581
 U  E  35 ( 4.6A)
None
C  E  34 ( 3.9A)
None
None
 1.21A 3a50C-3al0C:
undetectable		 3a50C-3al0C:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 THR C 562
LEU C 572
LEU C 565
ILE C 569
LEU C 581
 U  E  35 ( 4.6A)
None
C  E  34 ( 3.9A)
None
None
 1.18A 3a50E-3al0C:
undetectable		 3a50E-3al0C:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 THR A 227
SER A 218
LYS A  97
 None
 1.02A 3aocC-3al0A:
undetectable		 3aocC-3al0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ILE A 238
PHE A  58
LEU A  15
GLU A  12
ALA A 156
 None
 1.41A 3apwB-3al0A:
undetectable		 3apwB-3al0A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 9 VAL A  94
ILE A  69
GLY A 159
ILE A 203
ILE A 217
 None
 1.11A 3ekqB-3al0A:
undetectable		 3ekqB-3al0A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 10 ILE B  11
GLN B  14
LEU B 196
ALA B 195
ILE B 119
 None
 0.98A 3falC-3al0B:
undetectable		 3falC-3al0B:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 11 ILE B  11
GLN B  14
LEU B 196
ALA B 195
ILE B 119
 None
 1.00A 3fc6A-3al0B:
undetectable		 3fc6A-3al0B:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 9 ALA B  66
LEU B 106
VAL B 181
ILE B  11
LEU B 196
 None
 1.32A 3fl9D-3al0B:
undetectable		 3fl9D-3al0B:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 4 LEU A 378
ALA A 248
VAL A 283
PRO A 250
 None
 1.21A 3gv1B-3al0A:
undetectable		 3gv1B-3al0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 9 ALA B  66
LEU B 106
VAL B 181
ILE B  11
LEU B 196
 None
 1.14A 3jw3B-3al0B:
undetectable		 3jw3B-3al0B:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 7 GLU A  23
LEU A  30
LYS A  34
ASN A  49
 None
 0.92A 3k8mA-3al0A:
undetectable		 3k8mA-3al0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 7 GLU A  23
LEU A  30
LYS A  34
ASN A  49
 None
 1.10A 3k8mB-3al0A:
undetectable		 3k8mB-3al0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 ASP B 281
SER A 195
PHE B 277
SER A 305
 None
 1.05A 3m0wE-3al0B:
undetectable
3m0wF-3al0B:
undetectable
3m0wG-3al0B:
undetectable
3m0wH-3al0B:
undetectable		 3m0wE-3al0B:
13.92
3m0wF-3al0B:
13.92
3m0wG-3al0B:
13.92
3m0wH-3al0B:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 ILE A 344
GLY B  44
LEU A  83
PHE C  81
ILE C  89
 None
 0.99A 3pwwA-3al0A:
undetectable		 3pwwA-3al0A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 8 PHE B 376
PHE B 380
PHE B 397
THR B 353
 None
None
None
G  E  53 ( 4.1A)
 0.90A 3t3sD-3al0B:
undetectable		 3t3sD-3al0B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima;
Thermotoga
maritima) 		5 / 11 PRO B  50
PRO B  52
THR A 226
PRO B 283
ASP B 281
 None
 1.13A 3t8nD-3al0B:
undetectable
3t8nF-3al0B:
undetectable		 3t8nD-3al0B:
12.89
3t8nF-3al0B:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		3 / 3 LYS B 130
VAL B 132
HIS C  88
 None
 1.12A 3tj7A-3al0B:
undetectable		 3tj7A-3al0B:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 ALA C 515
ALA C 555
LEU C 551
LEU C 503
LEU C 588
 None
 1.05A 3uvvA-3al0C:
undetectable		 3uvvA-3al0C:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		3 / 3 ARG B 250
GLU B 251
THR B 252
 None
 0.79A 3v4tA-3al0B:
undetectable		 3v4tA-3al0B:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 8 LEU B 428
ILE B 425
ASN B 467
ILE B 419
 None
 0.83A 3wxoA-3al0B:
undetectable		 3wxoA-3al0B:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 7 PHE C 371
VAL C 143
ILE C 351
GLU C 374
 None
None
GSU  C1001 (-4.4A)
None
 1.09A 4a97E-3al0C:
undetectable		 4a97E-3al0C:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 ARG A 367
ARG A 368
ILE A 298
 None
 0.86A 4b7qA-3al0A:
undetectable		 4b7qA-3al0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 ARG A 367
ARG A 368
ILE A 298
 None
 0.79A 4b7qC-3al0A:
undetectable		 4b7qC-3al0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		5 / 11 VAL C  57
SER A 196
PHE B 277
ARG A 367
THR A 227
 None
 1.46A 4eilE-3al0C:
undetectable		 4eilE-3al0C:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 7 PHE B 376
PHE B 380
PHE B 397
THR B 353
 None
None
None
G  E  53 ( 4.1A)
 0.87A 4ejgA-3al0B:
undetectable		 4ejgA-3al0B:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		3 / 3 ASP A 221
ARG C  69
THR A  93
 None
 0.89A 4i13A-3al0A:
undetectable		 4i13A-3al0A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 8 GLU B 234
GLU B 251
GLU B 249
TYR B   3
 None
 1.23A 4mj8A-3al0B:
undetectable
4mj8C-3al0B:
undetectable		 4mj8A-3al0B:
16.88
4mj8C-3al0B:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		3 / 3 ASP A 221
ARG C  69
THR A  93
 None
 0.88A 4p3rA-3al0A:
undetectable		 4p3rA-3al0A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 6 LEU C 381
HIS C 140
TYR C 450
GLU C 369
 None
 1.10A 4pahA-3al0C:
undetectable		 4pahA-3al0C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 ILE A 413
ASP A 161
ARG A 367
 None
 0.55A 4pstA-3al0A:
undetectable		 4pstA-3al0A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		3 / 3 ILE C  35
ASP A 401
ARG A 343
 None
 0.78A 4pstA-3al0C:
undetectable		 4pstA-3al0C:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 6 ASN A 431
GLU A 264
GLU A 268
TYR A 462
 None
 1.50A 4twdG-3al0A:
undetectable
4twdH-3al0A:
undetectable		 4twdG-3al0A:
20.33
4twdH-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		4 / 4 GLY B 194
LEU B 177
PHE B 173
ILE B  11
 None
 0.96A 4xv2A-3al0B:
1.3		 4xv2A-3al0B:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 7 ASP A 198
GLY A 159
THR A 162
LYS A  66
 None
 1.06A 4zxiA-3al0A:
undetectable		 4zxiA-3al0A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 7 PRO B 468
ASN B 472
ILE B 475
PHE B 454
VAL B 458
 C  E  56 ( 3.8A)
C  E  56 ( 4.0A)
None
None
None
 1.25A 5bmvC-3al0B:
undetectable		 5bmvC-3al0B:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 6 GLU A 215
ASP A 161
ARG A 167
GLY A 177
 None
 0.95A 5cdnT-3al0A:
undetectable
5cdnU-3al0A:
undetectable		 5cdnT-3al0A:
24.19
5cdnU-3al0A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 4 LEU C 350
ILE C 348
GLY C 416
ILE C 412
 GSU  C1001 (-3.8A)
None
None
None
 0.83A 5dzk3-3al0C:
undetectable
5dzkm-3al0C:
undetectable		 5dzk3-3al0C:
4.65
5dzkm-3al0C:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 5 ILE C 348
GLY C 416
ILE C 412
LEU C 350
 None
None
None
GSU  C1001 (-3.8A)
 0.80A 5dzkB-3al0C:
undetectable
5dzkI-3al0C:
undetectable
5dzkW-3al0C:
undetectable		 5dzkB-3al0C:
18.89
5dzkI-3al0C:
15.62
5dzkW-3al0C:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 5 ILE C 348
GLY C 416
ILE C 412
LEU C 350
 None
None
None
GSU  C1001 (-3.8A)
 0.80A 5dzki-3al0C:
undetectable
5dzkj-3al0C:
undetectable
5dzkx-3al0C:
undetectable		 5dzki-3al0C:
15.62
5dzkj-3al0C:
15.62
5dzkx-3al0C:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		4 / 6 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.86A 5eckA-3al0A:
undetectable		 5eckA-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		4 / 6 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.91A 5eckD-3al0A:
undetectable		 5eckD-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		4 / 6 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.68A 5eclA-3al0A:
undetectable		 5eclA-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		4 / 6 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.87A 5eclD-3al0A:
undetectable		 5eclD-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
Thermotoga
maritima;
synthetic
construct) 		4 / 8 ALA A 293
THR A 294
VAL A 297
VAL C  45
 None
 0.75A 5ecnD-3al0A:
undetectable		 5ecnD-3al0A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 6 PHE A 193
PHE A 125
VAL A 340
ASP A 112
 None
 1.23A 5hesA-3al0A:
undetectable		 5hesA-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 HIS C 142
GLY C 144
GLY C 321
ASP C 323
LEU C 359
 GSU  C1001 ( 4.8A)
GSU  C1001 (-3.5A)
GSU  C1001 (-2.7A)
GSU  C1001 (-3.0A)
GSU  C1001 (-4.6A)
 1.07A 5hg0A-3al0C:
8.8		 5hg0A-3al0C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 HIS C 142
GLY C 144
VAL C 306
ASP C 323
LEU C 359
 GSU  C1001 ( 4.8A)
GSU  C1001 (-3.5A)
None
GSU  C1001 (-3.0A)
GSU  C1001 (-4.6A)
 1.04A 5hg0A-3al0C:
8.8		 5hg0A-3al0C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		5 / 12 HIS C 142
GLY C 144
VAL C 306
ASP C 323
LEU C 359
 GSU  C1001 ( 4.8A)
GSU  C1001 (-3.5A)
None
GSU  C1001 (-3.0A)
GSU  C1001 (-4.6A)
 1.03A 5hg0B-3al0C:
8.9		 5hg0B-3al0C:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 8 GLN C 550
GLY C 554
THR C 557
LEU C 560
 U  E  35 ( 3.6A)
None
None
None
 0.98A 5hwaA-3al0C:
0.1		 5hwaA-3al0C:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		5 / 12 ILE A 452
ALA A 455
PHE A 247
LEU A 276
GLY A 441
 None
 0.97A 5i73A-3al0A:
undetectable		 5i73A-3al0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 5 ASP A 209
THR A 206
ARG A 454
GLU A  12
 None
 1.49A 5k9dA-3al0A:
undetectable		 5k9dA-3al0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 8 ARG C 208
GLU C 211
GLY C 205
PRO C 206
 None
 1.09A 5kf8A-3al0C:
undetectable		 5kf8A-3al0C:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		3 / 3 THR A 128
PRO A 471
ARG A   7
 None
 0.85A 5nd7B-3al0A:
undetectable		 5nd7B-3al0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 8 HIS C 142
VAL C 368
THR C 148
ALA C 149
 GSU  C1001 ( 4.8A)
None
GSU  C1001 (-3.0A)
None
 0.91A 5tt3H-3al0C:
undetectable		 5tt3H-3al0C:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 8 SER A 304
ILE A 344
LEU A 351
PRO A 300
 None
 1.09A 5u4sB-3al0A:
undetectable		 5u4sB-3al0A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 6 THR C 562
ARG C 553
ILE C 569
GLU C 570
 U  E  35 ( 4.6A)
C  E  34 ( 2.8A)
None
None
 1.28A 5uigA-3al0C:
undetectable		 5uigA-3al0C:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		3 / 3 ARG B 357
PHE B 334
LEU B 371
 C  E  61 ( 3.7A)
None
None
 0.70A 5veuA-3al0B:
undetectable		 5veuA-3al0B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 5 VAL A 207
PRO A 202
GLY A 177
TYR A 178
 None
 0.94A 5x80A-3al0A:
undetectable
5x80B-3al0A:
undetectable		 5x80A-3al0A:
16.45
5x80B-3al0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 7 VAL A 207
PRO A 202
GLY A 177
TYR A 178
 None
 0.84A 5x80C-3al0A:
undetectable
5x80D-3al0A:
undetectable		 5x80C-3al0A:
16.45
5x80D-3al0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 5 PRO A 202
GLY A 177
TYR A 178
VAL A 207
 None
 0.90A 5x80C-3al0A:
undetectable
5x80D-3al0A:
undetectable		 5x80C-3al0A:
16.45
5x80D-3al0A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima) 		5 / 12 ILE B  11
GLN B  14
LEU B 196
ALA B 195
ILE B 119
 None
 0.97A 6a5zL-3al0B:
undetectable		 6a5zL-3al0B:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
(Thermotoga
maritima) 		4 / 4 GLY A 419
ARG A 167
ASN A 416
LEU A 420
 None
 1.25A 6b58A-3al0A:
undetectable		 6b58A-3al0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT
C,LINKER,GLUTAMATE--
TRNA LIGASE 2
(Thermotoga
maritima;
synthetic
construct) 		4 / 9 PHE C 304
VAL C 307
HIS C 311
LEU C 288
 None
 0.86A 6c2mD-3al0C:
undetectable		 6c2mD-3al0C:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima;
Thermotoga
maritima) 		5 / 11 PRO A 300
SER A 304
LEU A 197
SER A 196
ASP B 281
 None
 1.42A 6dlzA-3al0A:
undetectable
6dlzD-3al0A:
2.2		 6dlzA-3al0A:
10.87
6dlzD-3al0A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
(Thermotoga
maritima;
Thermotoga
maritima) 		5 / 11 PRO A 300
SER A 304
LEU A 197
SER A 196
ASP B 281
 None
 1.42A 6dm1A-3al0A:
undetectable
6dm1D-3al0A:
2.2		 6dm1A-3al0A:
10.87
6dm1D-3al0A:
10.87