SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3al2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A1420
HIS A1436
LEU A1430
GLU A1433
ALA A1434
 None
 0.93A 1mjlA-3al2A:
undetectable
1mjlB-3al2A:
undetectable		 1mjlA-3al2A:
18.80
1mjlB-3al2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 4 GLY A1392
VAL A1390
TRP A1397
GLY A1396
 None
 1.22A 1ng8A-3al2A:
undetectable		 1ng8A-3al2A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 4 GLY A1392
VAL A1390
TRP A1397
GLY A1396
 None
 1.21A 1ng8B-3al2A:
undetectable		 1ng8B-3al2A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A1423
PRO A1424
LEU A1430
 None
 0.58A 2po5B-3al2A:
2.6		 2po5B-3al2A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A1423
PRO A1424
LEU A1430
 None
 0.57A 2po7B-3al2A:
3.8		 2po7B-3al2A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A1296
HIS A1285
GLU A1288
 None
 0.81A 2x45B-3al2A:
undetectable		 2x45B-3al2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A1296
HIS A1285
GLU A1288
 None
 0.83A 2x45C-3al2A:
undetectable		 2x45C-3al2A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 8 TRP A1397
LEU A1473
GLY A1418
ALA A1323
 None
 0.82A 2xfsA-3al2A:
undetectable		 2xfsA-3al2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 8 TRP A1397
LEU A1473
GLY A1418
ALA A1323
 None
 0.86A 2xh9A-3al2A:
undetectable		 2xh9A-3al2A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A1407
ASP A1471
GLN A1366
 None
 0.89A 3lcvB-3al2A:
undetectable		 3lcvB-3al2A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A1369
LEU A1372
ARG A1376
GLU A1476
 None
 1.47A 3zmdA-3al2A:
undetectable
3zmdB-3al2A:
undetectable		 3zmdA-3al2A:
24.08
3zmdB-3al2A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		5 / 10 GLU A1350
VAL A1328
ILE A1307
ILE A1295
PHE A1300
 None
 1.21A 4qt3A-3al2A:
undetectable		 4qt3A-3al2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 5 HIS A1311
SER A1274
GLN A1367
TYR A1318
 None
SO4  A   1 (-4.7A)
None
None
 1.47A 5fuqA-3al2A:
0.0
5fuqB-3al2A:
0.0		 5fuqA-3al2A:
21.51
5fuqB-3al2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_B_ACTB1276_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 4 TYR A1318
HIS A1311
SER A1274
GLN A1367
 None
None
SO4  A   1 (-4.7A)
None
 1.50A 5fuqA-3al2A:
0.0
5fuqB-3al2A:
0.0		 5fuqA-3al2A:
21.51
5fuqB-3al2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A1372
GLY A1352
SER A1353
SER A1354
 None
 1.32A 5uunA-3al2A:
undetectable		 5uunA-3al2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1
(Homo
sapiens) 		4 / 4 LEU A1372
GLY A1352
SER A1353
SER A1354
 None
 1.34A 5uunB-3al2A:
undetectable		 5uunB-3al2A:
22.34