SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3al8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 12 ILE A 335
THR A 436
VAL A 425
LEU A 460
ILE A 405
 None
 1.35A 1kqwA-3al8A:
undetectable		 1kqwA-3al8A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 THR A 106
ASN A 141
ASP A 103
GLU A 158
 None
 1.14A 1mxgA-3al8A:
undetectable		 1mxgA-3al8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 7 THR A 505
PHE A 503
ARG A 486
LYS A 444
 None
 1.22A 2kotA-3al8A:
undetectable		 2kotA-3al8A:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 6 ARG A 208
THR A 188
ASN A 141
ASP A 103
 None
 1.33A 2okcA-3al8A:
undetectable		 2okcA-3al8A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_T_CHDT1085_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 10 MET A 488
GLY A 489
THR A 300
ARG A 486
GLY A 441
 None
 1.29A 2y69A-3al8A:
undetectable
2y69B-3al8A:
0.0
2y69T-3al8A:
0.0		 2y69A-3al8A:
21.01
2y69B-3al8A:
17.63
2y69T-3al8A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 THR A 436
ARG A 494
LEU A 312
ASP A 331
 None
 1.03A 2zw9A-3al8A:
5.1		 2zw9A-3al8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 12 SER A  24
ARG A 413
GLY A 324
ILE A 295
ASN A 294
 None
 1.47A 3a25A-3al8A:
undetectable		 3a25A-3al8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 11 MET A 488
GLY A 489
THR A 300
ARG A 486
GLY A 441
 None
 1.30A 3abkA-3al8A:
undetectable
3abkB-3al8A:
0.0
3abkT-3al8A:
0.0		 3abkA-3al8A:
21.01
3abkB-3al8A:
17.63
3abkT-3al8A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 10 ARG A 486
GLY A 441
MET A 488
GLY A 489
THR A 300
 None
 1.29A 3ablG-3al8A:
0.0
3ablN-3al8A:
undetectable
3ablO-3al8A:
0.0		 3ablG-3al8A:
8.99
3ablN-3al8A:
21.01
3ablO-3al8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 VAL A 425
THR A 436
GLY A 430
ALA A 429
 None
 0.75A 3aruA-3al8A:
undetectable		 3aruA-3al8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		3 / 3 SER A 381
GLY A 263
SER A 275
 None
 0.54A 3loqA-3al8A:
undetectable		 3loqA-3al8A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 6 TYR A 500
GLN A 491
ILE A  61
SER A 496
 None
 1.22A 3pmzD-3al8A:
undetectable		 3pmzD-3al8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		3 / 3 TYR A 228
LEU A 182
LYS A 181
 None
 0.67A 3sueD-3al8A:
undetectable		 3sueD-3al8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 11 MET A 488
GLY A 489
THR A 300
ARG A 486
GLY A 441
 None
 1.30A 3x2qA-3al8A:
undetectable
3x2qB-3al8A:
undetectable
3x2qT-3al8A:
undetectable		 3x2qA-3al8A:
21.01
3x2qB-3al8A:
17.63
3x2qT-3al8A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 7 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.11A 4a97E-3al8A:
undetectable		 4a97E-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.09A 4a97C-3al8A:
undetectable		 4a97C-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.09A 4a97D-3al8A:
undetectable		 4a97D-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.04A 4a97G-3al8A:
undetectable		 4a97G-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 PHE A 291
TYR A 292
ILE A 295
ASN A 294
 None
 1.10A 4a97I-3al8A:
undetectable		 4a97I-3al8A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 THR A 314
LEU A 448
LEU A 440
GLY A 441
 None
 0.84A 4c9nA-3al8A:
undetectable		 4c9nA-3al8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		3 / 3 ASP A  57
ARG A  73
ASP A 480
 None
 0.81A 4fp9D-3al8A:
undetectable		 4fp9D-3al8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		3 / 3 ASP A 179
TRP A 273
SER A 204
 None
 1.09A 4lrhF-3al8A:
undetectable		 4lrhF-3al8A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		4 / 8 TRP A 353
PHE A 343
GLU A 345
THR A 209
 None
 1.05A 5hqaA-3al8A:
2.8		 5hqaA-3al8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_G_CHDG102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 10 ARG A 486
GLY A 441
MET A 488
GLY A 489
THR A 300
 None
 1.29A 5iy5G-3al8A:
0.0
5iy5N-3al8A:
undetectable
5iy5O-3al8A:
0.0		 5iy5G-3al8A:
10.43
5iy5N-3al8A:
21.01
5iy5O-3al8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 11 ARG A 486
GLY A 441
MET A 488
GLY A 489
THR A 300
 None
 1.29A 5x1fG-3al8A:
0.0
5x1fN-3al8A:
undetectable
5x1fO-3al8A:
0.0		 5x1fG-3al8A:
8.99
5x1fN-3al8A:
21.01
5x1fO-3al8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 11 MET A 488
GLY A 489
THR A 300
ARG A 486
GLY A 441
 None
 1.31A 5xdxA-3al8A:
undetectable
5xdxB-3al8A:
0.0
5xdxT-3al8A:
0.0		 5xdxA-3al8A:
21.01
5xdxB-3al8A:
17.63
5xdxT-3al8A:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 9 ARG A 486
GLY A 441
MET A 488
GLY A 489
THR A 300
 None
 1.23A 6nknG-3al8A:
0.0
6nknN-3al8A:
undetectable
6nknO-3al8A:
0.0		 6nknG-3al8A:
8.99
6nknN-3al8A:
21.01
6nknO-3al8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 10 ARG A 486
GLY A 441
MET A 488
GLY A 489
THR A 300
 None
 1.25A 6nmfG-3al8A:
0.0
6nmfN-3al8A:
undetectable
6nmfO-3al8A:
0.0		 6nmfG-3al8A:
8.99
6nmfN-3al8A:
21.01
6nmfO-3al8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3al8 SEMAPHORIN-6A
(Mus
musculus) 		5 / 10 ARG A 486
GLY A 441
MET A 488
GLY A 489
THR A 300
 None
 1.24A 6nmpG-3al8A:
0.0
6nmpN-3al8A:
undetectable
6nmpO-3al8A:
0.0		 6nmpG-3al8A:
8.99
6nmpN-3al8A:
21.01
6nmpO-3al8A:
17.63