SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3al9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3al9 PLEXIN-A2
(Mus
musculus) 		5 / 11 LEU A 198
GLY A 246
GLY A 170
TYR A 243
LEU A 383
 None
 1.15A 1p91A-3al9A:
undetectable		 1p91A-3al9A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		5 / 12 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.36A 2iyfB-3al9A:
undetectable		 2iyfB-3al9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		5 / 12 THR A 232
LEU A 233
ILE A 241
THR A 167
VAL A 162
 None
 1.12A 3a51B-3al9A:
undetectable		 3a51B-3al9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 5 TYR A 293
ILE A 241
TYR A 243
THR A 167
 None
 1.30A 3dgqA-3al9A:
undetectable		 3dgqA-3al9A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 8 SER A 489
LEU A 493
TYR A 496
TYR A 494
 None
 0.99A 3i45A-3al9A:
undetectable		 3i45A-3al9A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 8 LEU A 424
ALA A 460
SER A 444
SER A 437
 None
 0.99A 3rodA-3al9A:
undetectable		 3rodA-3al9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 7 SER A 434
VAL A 475
ILE A 482
TYR A 438
 None
 0.97A 3tneB-3al9A:
undetectable		 3tneB-3al9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 8 TYR A  63
ASP A 143
ASP A 144
LEU A 126
 None
 0.92A 4f8hA-3al9A:
undetectable
4f8hB-3al9A:
undetectable		 4f8hA-3al9A:
19.27
4f8hB-3al9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 8 TYR A  63
ASP A 143
ASP A 144
LEU A 126
 None
 0.98A 4f8hB-3al9A:
undetectable
4f8hC-3al9A:
undetectable		 4f8hB-3al9A:
19.27
4f8hC-3al9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 8 TYR A  63
ASP A 143
ASP A 144
LEU A 126
 None
 0.94A 4f8hC-3al9A:
undetectable
4f8hD-3al9A:
undetectable		 4f8hC-3al9A:
19.27
4f8hD-3al9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 8 TYR A  63
ASP A 143
ASP A 144
LEU A 126
 None
 0.93A 4f8hD-3al9A:
undetectable
4f8hE-3al9A:
undetectable		 4f8hD-3al9A:
19.27
4f8hE-3al9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 8 LEU A 126
TYR A  63
ASP A 143
ASP A 144
 None
 0.94A 4f8hA-3al9A:
undetectable
4f8hE-3al9A:
undetectable		 4f8hA-3al9A:
19.27
4f8hE-3al9A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 7 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.85A 4lb2A-3al9A:
0.4		 4lb2A-3al9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 7 LEU A 159
VAL A 136
PRO A 151
TYR A 215
 None
 0.96A 4lb2A-3al9A:
0.4		 4lb2A-3al9A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		5 / 11 VAL A 188
ILE A 226
TYR A 243
TYR A 215
SER A 199
 None
 1.34A 4m83B-3al9A:
undetectable		 4m83B-3al9A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		3 / 3 ARG A 174
ASP A 179
ARG A 125
 None
 0.84A 4mx0A-3al9A:
4.7		 4mx0A-3al9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 4 ASN A  51
SER A  43
ALA A  66
VAL A  70
 None
 1.32A 5nm5A-3al9A:
undetectable		 5nm5A-3al9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 6 ARG A 205
GLY A 180
GLU A 123
SER A 122
 None
 0.87A 5ny7A-3al9A:
undetectable		 5ny7A-3al9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.31A 5oexA-3al9A:
8.2		 5oexA-3al9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.35A 5oexB-3al9A:
8.1		 5oexB-3al9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.35A 5oexC-3al9A:
7.5		 5oexC-3al9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3al9 PLEXIN-A2
(Mus
musculus) 		3 / 3 LYS A 154
HIS A 153
HIS A 157
 None
 1.31A 5oexD-3al9A:
10.0		 5oexD-3al9A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3al9 PLEXIN-A2
(Mus
musculus) 		4 / 5 TYR A  38
VAL A 475
LEU A 455
SER A 510
 None
None
None
EDO  A8301 (-2.3A)
 1.18A 6a7pA-3al9A:
undetectable		 6a7pA-3al9A:
21.70