SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3all'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 PHE A  21
ALA A  48
GLY A  52
ILE A  53
LEU A  63
 FAD  A 380 (-4.7A)
None
None
FAD  A 380 (-4.5A)
None
 1.17A 1kglA-3allA:
undetectable		 1kglA-3allA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		3 / 3 PHE A 251
TRP A  85
GLU A  83
 None
 1.04A 1mogA-3allA:
undetectable		 1mogA-3allA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 9 ILE A 332
TYR A 375
ILE A 335
GLU A 364
ARG A 338
 None
 1.36A 1mrgA-3allA:
undetectable		 1mrgA-3allA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		4 / 6 LEU A  24
PHE A  21
ALA A  22
LEU A  39
 None
FAD  A 380 (-4.7A)
FAD  A 380 (-3.2A)
None
 1.00A 1ukbA-3allA:
undetectable		 1ukbA-3allA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		4 / 8 GLY A  18
THR A  25
ALA A  26
ALA A  27
 FAD  A 380 (-3.3A)
None
None
None
 0.55A 2ej3A-3allA:
undetectable		 2ej3A-3allA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		4 / 8 GLY A  18
THR A  25
ALA A  26
ALA A  27
 FAD  A 380 (-3.3A)
None
None
None
 0.57A 2ej3C-3allA:
0.5		 2ej3C-3allA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 11 LEU A 315
GLY A 318
SER A 312
LEU A 311
SER A 310
 None
 0.97A 2qmmA-3allA:
undetectable
2qmmB-3allA:
undetectable		 2qmmA-3allA:
19.16
2qmmB-3allA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		3 / 3 ARG A  61
GLY A  59
SER A  76
 None
 0.60A 2xctB-3allA:
undetectable		 2xctB-3allA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		4 / 8 ALA A  17
HIS A  40
GLY A 154
ILE A 152
 FAD  A 380 ( 4.5A)
None
None
None
 0.76A 2zm9A-3allA:
undetectable		 2zm9A-3allA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 LEU A 325
ALA A  14
ALA A 284
VAL A 286
LEU A 113
 None
 1.23A 3b0wB-3allA:
undetectable		 3b0wB-3allA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		4 / 8 LEU A 113
ILE A  28
ARG A 118
GLY A 121
 None
 0.90A 3b9lA-3allA:
undetectable		 3b9lA-3allA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		6 / 10 GLY A  50
ALA A  51
VAL A 184
GLY A 225
LEU A 213
ILE A 183
 None
None
None
None
GOL  A 384 (-4.7A)
None
 1.28A 3em3A-3allA:
undetectable		 3em3A-3allA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 10 LEU A  30
ASP A 123
VAL A 122
ILE A 124
GLY A  19
 None
None
None
None
FAD  A 380 ( 4.4A)
 0.99A 3em3B-3allA:
undetectable		 3em3B-3allA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 LEU A  30
ASP A 123
VAL A 122
ILE A 124
GLY A  19
 None
None
None
None
FAD  A 380 ( 4.4A)
 0.94A 3em6B-3allA:
undetectable		 3em6B-3allA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 SER A  43
PHE A  21
GLY A  20
GLY A  18
LEU A  46
 FAD  A 380 (-3.5A)
FAD  A 380 (-4.7A)
FAD  A 380 (-3.4A)
FAD  A 380 (-3.3A)
None
 1.29A 3fzgA-3allA:
undetectable		 3fzgA-3allA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 9 LEU A 315
ALA A 327
GLU A 329
ALA A 284
THR A 279
 None
None
None
None
GOL  A 383 (-3.7A)
 1.03A 3mdvA-3allA:
undetectable		 3mdvA-3allA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A 287
GLY A 157
ALA A 301
LEU A 285
THR A  25
 FAD  A 380 (-3.4A)
FAD  A 380 ( 3.8A)
FAD  A 380 (-3.0A)
None
None
 1.06A 3p2kA-3allA:
undetectable		 3p2kA-3allA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 LEU A 151
GLY A  23
ALA A  22
LEU A  30
GLY A 157
 None
None
FAD  A 380 (-3.2A)
None
FAD  A 380 ( 3.8A)
 0.97A 3uq6B-3allA:
2.7		 3uq6B-3allA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 LEU A 151
GLY A  23
ALA A  22
LEU A  30
GLY A 157
 None
None
FAD  A 380 (-3.2A)
None
FAD  A 380 ( 3.8A)
 0.97A 3vaqB-3allA:
undetectable		 3vaqB-3allA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		4 / 8 ARG A  38
TRP A  35
GLU A  15
ARG A  12
 None
 1.17A 4bqfB-3allA:
undetectable		 4bqfB-3allA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		6 / 12 LEU A 151
GLY A  19
ALA A  22
VAL A  16
LEU A  30
GLY A 157
 None
FAD  A 380 ( 4.4A)
FAD  A 380 (-3.2A)
None
None
FAD  A 380 ( 3.8A)
 1.42A 4dc3A-3allA:
3.0		 4dc3A-3allA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		3 / 3 LEU A 262
LYS A 263
THR A 264
 None
 0.51A 4lj0A-3allA:
undetectable		 4lj0A-3allA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 11 LEU A  30
ASP A 123
VAL A 122
ILE A 124
GLY A  19
 None
None
None
None
FAD  A 380 ( 4.4A)
 0.90A 4njtA-3allA:
undetectable		 4njtA-3allA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 ALA A  48
LEU A  46
GLY A  23
ASP A 288
ALA A 308
 None
None
None
FAD  A 380 (-3.1A)
None
 1.04A 4pclA-3allA:
3.0		 4pclA-3allA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 11 LEU A  30
ASP A 123
VAL A 122
ILE A 124
GLY A  19
 None
None
None
None
FAD  A 380 ( 4.4A)
 0.98A 4rvjA-3allA:
undetectable		 4rvjA-3allA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 10 GLY A 154
VAL A 153
THR A 279
VAL A 286
LEU A 311
 None
None
GOL  A 383 (-3.7A)
None
None
 1.22A 4yb6A-3allA:
undetectable
4yb6E-3allA:
undetectable		 4yb6A-3allA:
23.31
4yb6E-3allA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 10 GLY A 154
VAL A 153
THR A 279
VAL A 286
LEU A 311
 None
None
GOL  A 383 (-3.7A)
None
None
 1.22A 4yb6B-3allA:
undetectable
4yb6C-3allA:
undetectable		 4yb6B-3allA:
23.31
4yb6C-3allA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 10 GLY A 154
VAL A 153
THR A 279
VAL A 286
LEU A 311
 None
None
GOL  A 383 (-3.7A)
None
None
 1.20A 4yb6C-3allA:
undetectable
4yb6F-3allA:
undetectable		 4yb6C-3allA:
23.31
4yb6F-3allA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 10 LEU A 311
GLY A 154
VAL A 153
THR A 279
VAL A 286
 None
None
None
GOL  A 383 (-3.7A)
None
 1.17A 4yb6A-3allA:
undetectable
4yb6D-3allA:
undetectable		 4yb6A-3allA:
23.31
4yb6D-3allA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		3 / 3 ARG A 338
TYR A 375
GLU A 364
 None
 0.48A 4zzbE-3allA:
undetectable		 4zzbE-3allA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 10 LEU A 242
VAL A 184
ILE A 212
LEU A 224
PRO A 185
 None
 1.07A 5ienB-3allA:
undetectable		 5ienB-3allA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 ILE A 103
GLY A  52
GLU A  83
ALA A 298
ILE A 212
 None
None
None
GOL  A 384 (-3.8A)
None
 1.06A 5ih0A-3allA:
0.0		 5ih0A-3allA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  23
GLY A  19
LEU A 113
VAL A 153
ALA A 289
 None
FAD  A 380 ( 4.4A)
None
None
None
 0.92A 5kpcA-3allA:
2.0		 5kpcA-3allA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 MET A 293
THR A 272
GLY A 287
ALA A 308
ASP A 288
 None
BME  A 381 ( 4.7A)
FAD  A 380 (-3.4A)
None
FAD  A 380 (-3.1A)
 0.97A 5kvaA-3allA:
2.5		 5kvaA-3allA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		5 / 12 MET A 293
THR A 272
GLY A 287
ALA A 308
ASP A 288
 None
BME  A 381 ( 4.7A)
FAD  A 380 (-3.4A)
None
FAD  A 380 (-3.1A)
 0.97A 5kvaB-3allA:
2.6		 5kvaB-3allA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE
(Mesorhizobium
japonicum) 		3 / 3 TYR A 223
ALA A 298
TYR A  54
 GOL  A 384 (-4.6A)
GOL  A 384 (-3.8A)
GOL  A 384 (-4.6A)
 0.87A 5uunB-3allA:
undetectable		 5uunB-3allA:
22.78