SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3alx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 6 ALA A 290
SER A 439
ARG A 253
LEU A 296
 None
 0.99A 1gahA-3alxA:
undetectable		 1gahA-3alxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 8 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 0.79A 1jlbA-3alxA:
undetectable		 1jlbA-3alxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 7 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 0.75A 1lweA-3alxA:
undetectable		 1lweA-3alxA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		5 / 11 PHE A 319
VAL A 367
GLY A 411
THR A 369
ILE A 306
 None
 0.97A 1phgA-3alxA:
undetectable		 1phgA-3alxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		5 / 10 GLY A 229
VAL A 257
GLY A 258
MET A 272
THR A 221
 None
 1.24A 1pwyE-3alxA:
undetectable		 1pwyE-3alxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		5 / 10 GLY A 229
VAL A 257
GLY A 258
MET A 272
THR A 221
 None
 1.25A 1v3qE-3alxA:
undetectable		 1v3qE-3alxA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		5 / 12 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.19A 1z9hA-3alxA:
undetectable		 1z9hA-3alxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		5 / 12 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.20A 1z9hB-3alxA:
undetectable		 1z9hB-3alxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		5 / 12 TYR A 350
PRO A 401
VAL A 478
ILE A 435
LEU A 454
 None
 1.19A 1z9hC-3alxA:
undetectable		 1z9hC-3alxA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		3 / 3 ILE A  78
ILE A 107
LEU A 122
 None
 0.55A 2prgA-3alxA:
undetectable		 2prgA-3alxA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 6 ASP A 530
TYR A 529
TYR A 540
LEU A 526
 None
 0.98A 2w98A-3alxA:
undetectable
2w98B-3alxA:
undetectable		 2w98A-3alxA:
20.04
2w98B-3alxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 8 ASN A 286
SER A 285
VAL A 220
PHE A 255
 None
 1.07A 2wekA-3alxA:
undetectable		 2wekA-3alxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 8 ASN A 286
SER A 285
VAL A 220
PHE A 255
 None
 1.05A 2wekB-3alxA:
undetectable		 2wekB-3alxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		3 / 3 TYR A 541
GLU A  75
THR A 121
 None
 0.91A 2y7hB-3alxA:
undetectable		 2y7hB-3alxA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 8 SER A 352
ASP A 442
VAL A 568
LEU A 566
 None
 1.07A 3jq7C-3alxA:
undetectable		 3jq7C-3alxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.40A 3jqaA-3alxA:
undetectable		 3jqaA-3alxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.41A 3jqaB-3alxA:
undetectable		 3jqaB-3alxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.43A 3jqaC-3alxA:
undetectable		 3jqaC-3alxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		4 / 6 SER A 204
PHE A 270
TYR A 228
PRO A 268
 None
 1.41A 3jqaD-3alxA:
undetectable		 3jqaD-3alxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		4 / 8 HIS A  61
VAL A  63
VAL A  64
ASP A 507
 None
 1.02A 3uy4A-3alxA:
undetectable		 3uy4A-3alxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		4 / 8 HIS A  61
VAL A  63
VAL A  64
ASP A 530
 None
 1.18A 3uy4A-3alxA:
undetectable		 3uy4A-3alxA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 8 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 0.88A 3v81C-3alxA:
undetectable		 3v81C-3alxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 8 ASP A 304
SER A 352
SER A 353
GLN A 567
 None
 0.98A 4af0A-3alxA:
undetectable		 4af0A-3alxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 7 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 1.07A 4b3qA-3alxA:
undetectable		 4b3qA-3alxA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Saguinus
oedipus;
Measles
morbillivirus;
synthetic
construct) 		3 / 3 LEU A 284
GLU A 303
SER A 285
 None
 0.84A 4ccqA-3alxA:
undetectable		 4ccqA-3alxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		3 / 3 LEU A  47
MET A 120
ASP A  94
 None
 0.50A 4j7xB-3alxA:
undetectable		 4j7xB-3alxA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 4 LEU A 299
SER A 414
LEU A 339
LEU A 321
 None
 1.10A 4n09A-3alxA:
undetectable		 4n09A-3alxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 8 LEU A 205
VAL A 234
TYR A 214
TYR A 275
 None
 0.82A 4puoC-3alxA:
undetectable		 4puoC-3alxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 4 ASN A 513
VAL A 525
THR A 455
ILE A 467
 None
 1.28A 4retA-3alxA:
undetectable		 4retA-3alxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 4 ASN A 513
VAL A 525
THR A 455
ILE A 467
 None
 1.28A 4retC-3alxA:
undetectable		 4retC-3alxA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		3 / 3 ASN A 274
PHE A 255
TYR A 232
 None
 0.83A 4u15A-3alxA:
undetectable		 4u15A-3alxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3alx HEMAGGLUTININ,LINKER
,CDW150
(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		4 / 7 TYR A 551
CSS A 570
TYR A 540
LEU A 517
 None
 1.43A 6cnkB-3alxA:
undetectable
6cnkC-3alxA:
undetectable		 6cnkB-3alxA:
9.69
6cnkC-3alxA:
8.92