SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3am3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifA-3am3A:
4.4		 1kifA-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifB-3am3A:
4.4		 1kifB-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifC-3am3A:
4.4		 1kifC-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifD-3am3A:
4.4		 1kifD-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifE-3am3A:
4.4		 1kifE-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifF-3am3A:
4.5		 1kifF-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifG-3am3A:
4.5		 1kifG-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 0.99A 1kifH-3am3A:
4.4		 1kifH-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 1.01A 1ve9A-3am3A:
4.4		 1ve9A-3am3A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 8 TYR A 277
PHE A 368
ALA A 319
MET A 372
 TCL  A 802 (-4.4A)
TCL  A 802 (-4.8A)
TCL  A 802 ( 3.3A)
None
 1.08A 1x8vA-3am3A:
undetectable		 1x8vA-3am3A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 1.03A 2du8G-3am3A:
4.5		 2du8G-3am3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 1.04A 2du8J-3am3A:
4.4		 2du8J-3am3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 8 GLU A 289
SER A 270
GLN A 271
ARG A 293
 None
 1.26A 3b9lA-3am3A:
undetectable		 3b9lA-3am3A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 6 THR A 410
THR A 309
LEU A 288
THR A 266
 None
 0.94A 3deuB-3am3A:
undetectable		 3deuB-3am3A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		5 / 12 SER A 388
GLY A 114
GLY A 106
TRP A 113
VAL A 134
 None
None
NAD  A 801 (-3.5A)
None
None
 1.05A 3gczA-3am3A:
5.7		 3gczA-3am3A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 8 THR A 229
LEU A 226
SER A 282
ASN A 218
 None
None
None
NAD  A 801 (-3.9A)
 1.10A 3kp2A-3am3A:
undetectable
3kp2B-3am3A:
undetectable		 3kp2A-3am3A:
20.26
3kp2B-3am3A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 7 PHE A 368
THR A 367
ASN A 324
ILE A 323
 TCL  A 802 (-4.8A)
None
None
None
 0.97A 3t01A-3am3A:
undetectable		 3t01A-3am3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 ILE A 391
VAL A 413
ILE A 411
VAL A 394
 None
 0.72A 4xdtA-3am3A:
undetectable		 4xdtA-3am3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 GLY A 313
TYR A 375
SER A 376
ASP A 414
 NAD  A 801 (-4.8A)
None
None
None
 1.11A 4xueA-3am3A:
6.5		 4xueA-3am3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		5 / 12 GLY A 313
TYR A 375
SER A 376
ASP A 414
ALA A 312
 NAD  A 801 (-4.8A)
None
None
None
NAD  A 801 (-3.6A)
 1.14A 4ymgB-3am3A:
7.7		 4ymgB-3am3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		5 / 12 TYR A 375
SER A 376
SER A 317
ASP A 414
ALA A 312
 None
None
NAD  A 801 (-2.9A)
None
NAD  A 801 (-3.6A)
 1.37A 4ymgB-3am3A:
7.7		 4ymgB-3am3A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		5 / 12 ALA A 116
GLY A 114
THR A 389
GLY A 392
PHE A 128
 None
 1.18A 5ybbA-3am3A:
3.8		 5ybbA-3am3A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 5 HIS A 214
ALA A 169
SER A 244
TYR A 243
 None
NAD  A 801 (-3.5A)
None
None
 1.32A 5yodF-3am3A:
undetectable		 5yodF-3am3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		5 / 9 ALA A 284
ALA A 219
GLY A 280
GLY A 233
SER A 239
 None
TCL  A 802 (-3.8A)
None
None
None
 1.21A 6bklE-3am3A:
undetectable
6bklF-3am3A:
undetectable
6bklG-3am3A:
undetectable
6bklH-3am3A:
undetectable		 6bklE-3am3A:
3.95
6bklF-3am3A:
3.95
6bklG-3am3A:
3.95
6bklH-3am3A:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		5 / 9 VAL A 413
PHE A 397
SER A 396
LEU A 398
ILE A 310
 None
 0.88A 6fdyU-3am3A:
undetectable		 6fdyU-3am3A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA810_0
(GEPHYRIN)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		3 / 3 LEU A 398
SER A 396
PHE A 397
 None
 0.67A 6fgcA-3am3A:
2.7		 6fgcA-3am3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.50A 6mn5A-3am3A:
undetectable		 6mn5A-3am3A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3am3 ENOYL-ACP REDUCTASE
(Plasmodium
falciparum) 		4 / 6 ASP A 176
TYR A 251
GLU A 196
ASP A 197
 None
 1.34A 6mn5C-3am3A:
undetectable		 6mn5C-3am3A:
12.70