SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3amj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 THR C 397
GLY C 401
VAL C 404
TYR C 118
ASN C 107
None
1.20A 1n2xA-3amjC:
undetectable
1n2xA-3amjC:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 GLU C 157
HIS C  81
HIS C  77
GLU C  80
ZN  C   1 (-1.9A)
ZN  C   1 (-3.4A)
ZN  C   1 (-3.2A)
ZN  C   1 ( 4.4A)
0.99A 1v7zE-3amjC:
undetectable
1v7zE-3amjC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
3 / 3 GLN C 251
HIS C 182
ARG C 185
None
1.07A 1zlqA-3amjC:
undetectable
1zlqA-3amjC:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 ALA C 108
HIS C  81
GLU C  80
HIS C  77
GLU C 157
None
ZN  C   1 (-3.4A)
ZN  C   1 ( 4.4A)
ZN  C   1 (-3.2A)
ZN  C   1 (-1.9A)
0.68A 2c6nA-3amjC:
undetectable
2c6nA-3amjC:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 SER B 314
GLY B 285
ALA B 288
GLY B 292
VAL B 408
None
0.98A 2nyuA-3amjB:
undetectable
2nyuA-3amjB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 SER B 314
GLY B 285
ALA B 288
GLY B 292
VAL B 408
None
0.99A 2nyuB-3amjB:
undetectable
2nyuB-3amjB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
3 / 3 LEU B 393
PRO B 394
ARG B 374
None
0.65A 2qd5A-3amjB:
undetectable
2qd5A-3amjB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
3 / 3 GLN C 201
THR C  72
TRP C 206
None
1.11A 2rctA-3amjC:
undetectable
2rctA-3amjC:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 TYR B  36
ALA B 223
ALA B 227
THR B 231
None
0.82A 2wx2B-3amjB:
undetectable
2wx2B-3amjB:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 GLY C 336
GLY C 326
LEU C 294
LEU C 340
LEU C 357
None
1.09A 2zbpA-3amjC:
undetectable
2zbpA-3amjC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 4 ARG C 136
ASP C 202
GLY C  74
THR C 115
None
1.41A 3k4vB-3amjC:
undetectable
3k4vB-3amjC:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 TYR B  36
ALA B 223
ALA B 227
THR B 231
None
0.75A 3khmA-3amjB:
undetectable
3khmA-3amjB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 6 VAL B 421
SER B 314
LEU B 166
LEU B 426
None
0.98A 3kk6A-3amjB:
undetectable
3kk6A-3amjB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 TYR B  36
ALA B 223
ALA B 227
THR B 231
None
0.77A 3l4dA-3amjB:
undetectable
3l4dA-3amjB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 LEU C 374
SER C 375
ARG C 420
ILE C 296
None
0.94A 3ln1A-3amjC:
undetectable
3ln1A-3amjC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 7 LEU C 374
SER C 375
ARG C 420
ILE C 296
None
0.95A 3ln1B-3amjC:
undetectable
3ln1B-3amjC:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 6 LEU B 144
GLU B 145
PRO B 142
ARG B 148
None
1.19A 3ltwA-3amjB:
undetectable
3ltwA-3amjB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_2
(HIV-1 PROTEASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 ARG B 274
LEU B 393
ILE B  22
VAL B 387
ILE B 388
None
1.07A 3mwsB-3amjB:
undetectable
3mwsB-3amjB:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
3 / 3 ARG C 332
LEU C 405
THR C 217
None
0.72A 3oxcA-3amjC:
undetectable
3oxcA-3amjC:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 4 LYS C 378
GLN C 417
ILE C 282
LEU C 294
None
1.31A 3qt0A-3amjC:
0.0
3qt0A-3amjC:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 GLY B 432
ALA B 257
ASP B 337
ALA B 336
VAL B 430
None
1.10A 4df3B-3amjB:
undetectable
4df3B-3amjB:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 ASN B 286
PHE B 316
ILE B 302
GLY B 328
ILE B 327
None
1.39A 4djfA-3amjB:
undetectable
4djfA-3amjB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 6 SER C 329
ASP C 328
SER C 331
ASP C 113
None
1.17A 4eysA-3amjC:
undetectable
4eysA-3amjC:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 ASN B 286
PHE B 325
VAL B 421
LEU B 298
None
1.08A 4f5zA-3amjB:
undetectable
4f5zA-3amjB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
3 / 3 LEU B 393
PRO B 394
ARG B 374
None
0.60A 4klrB-3amjB:
undetectable
4klrB-3amjB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 ALA B 223
LEU B 130
GLY B  32
LEU B 234
PHE B  52
None
1.17A 4kykA-3amjB:
undetectable
4kykB-3amjB:
undetectable
4kykA-3amjB:
18.38
4kykB-3amjB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
6 / 12 LEU C 126
ALA C 233
GLY C 131
ALA C 134
ALA C 216
VAL C  59
None
1.32A 4nkxB-3amjC:
undetectable
4nkxB-3amjC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 5 ILE C 154
ASP C 163
GLU C 157
VAL C 188
None
None
ZN  C   1 (-1.9A)
None
1.05A 4nkxC-3amjC:
undetectable
4nkxC-3amjC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 5 ILE C 154
ASP C 163
GLU C 157
VAL C 188
None
None
ZN  C   1 (-1.9A)
None
1.03A 4nkxD-3amjC:
undetectable
4nkxD-3amjC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 GLN B 319
GLY B  55
ALA B  71
ALA B 110
TYR B 205
None
1.32A 4pclB-3amjB:
undetectable
4pclB-3amjB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 MET C 393
GLN C 119
VAL C  44
LEU C 126
LEU C  55
None
1.43A 4qztA-3amjC:
undetectable
4qztA-3amjC:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 6 LYS B 177
GLY B 176
TYR B 175
ALA B 174
None
1.22A 4yshB-3amjB:
undetectable
4yshB-3amjB:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 12 GLU B 147
SER B  72
GLN B 161
ARG B 150
GLY B 154
None
1.37A 5m50E-3amjB:
undetectable
5m50E-3amjB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
3 / 3 ALA B  29
GLN B 229
THR B 231
None
0.65A 5n0oA-3amjB:
undetectable
5n0oA-3amjB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 10 ALA C 228
LEU C 232
LEU C 126
GLU C  48
VAL C  46
None
1.12A 5v02B-3amjC:
undetectable
5v02R-3amjC:
undetectable
5v02B-3amjC:
13.05
5v02R-3amjC:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 9 LEU C 240
ALA C 134
VAL C 218
MET C 130
GLY C 212
None
1.23A 5w5vA-3amjC:
undetectable
5w5vA-3amjC:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 4 PHE B 279
LEU B 360
LEU B 367
VAL B 413
None
1.32A 5xxiA-3amjB:
undetectable
5xxiA-3amjB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
5 / 9 ALA B  67
SER B  68
ALA B 107
SER B  56
GLY B  55
None
1.17A 6bklE-3amjB:
undetectable
6bklF-3amjB:
undetectable
6bklG-3amjB:
undetectable
6bklH-3amjB:
undetectable
6bklE-3amjB:
5.28
6bklF-3amjB:
5.28
6bklG-3amjB:
5.28
6bklH-3amjB:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 ILE B 226
THR B 225
GLN B 229
SER B  31
None
1.13A 6c06C-3amjB:
undetectable
6c06C-3amjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
4 / 8 LEU C 407
GLY C 406
ARG C  62
TYR C 114
None
0.88A 6ce2A-3amjC:
undetectable
6ce2A-3amjC:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp.
A1)
6 / 12 ALA B  91
LEU B 101
PHE B  52
HIS B 201
THR B  78
LEU B  85
None
1.50A 6djzC-3amjB:
undetectable
6djzC-3amjB:
20.00