SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3anx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 4 HIS A  64
LEU A  49
LEU A 113
LEU A 136
 None
MTA  A 315 ( 4.4A)
None
None
 1.15A 1a4lD-3anxA:
undetectable		 1a4lD-3anxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ASP A 108
ASP A 140
ASP A 158
 MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.9A)
 0.77A 1eizA-3anxA:
11.2		 1eizA-3anxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  96
LEU A  92
VAL A 101
HIS A  98
HIS A  69
 None
 1.33A 1ie9A-3anxA:
undetectable		 1ie9A-3anxA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 6 ASP A 140
GLY A  85
ILE A  83
ILE A 138
 MTA  A 315 (-3.9A)
MTA  A 315 (-3.2A)
None
None
 0.94A 1n49D-3anxA:
undetectable		 1n49D-3anxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A  87
ILE A 109
ASP A 110
ASP A 140
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-3.9A)
 0.70A 1qaoA-3anxA:
8.1		 1qaoA-3anxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 TYR A  63
GLU A  88
ALA A 128
GLY A  85
GLY A  87
 None
None
None
MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
 1.13A 1x1aA-3anxA:
11.8		 1x1aA-3anxA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A  87
THR A  91
ASP A 108
ALA A 141
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.3A)
MTA  A 315 (-3.5A)
 0.79A 2gluA-3anxA:
12.3		 2gluA-3anxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ASP A 108
ASP A 140
ASP A 158
 MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.9A)
 0.71A 2igtA-3anxA:
8.3		 2igtA-3anxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ASP A 108
ASP A 140
ASP A 158
 MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.9A)
 0.70A 2igtB-3anxA:
7.5		 2igtB-3anxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
GLY A  87
ILE A 109
ASP A 110
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-4.3A)
 0.90A 2nxeB-3anxA:
11.9		 2nxeB-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 ALA A  90
ASP A 108
ASP A 140
ASP A 158
 None
MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.9A)
 0.62A 2nyuB-3anxA:
10.9		 2nyuB-3anxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 8 HIS A 210
VAL A 213
LEU A 282
GLY A 235
 None
 0.86A 2xfsA-3anxA:
undetectable		 2xfsA-3anxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 8 HIS A 210
VAL A 213
LEU A 282
GLY A 235
 None
 0.86A 2xh9A-3anxA:
undetectable		 2xh9A-3anxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 VAL A  24
ARG A  23
GLY A   4
ASP A   2
 None
 0.96A 2y05A-3anxA:
6.0
2y05B-3anxA:
4.8		 2y05A-3anxA:
23.14
2y05B-3anxA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A  87
ASP A 110
ALA A 141
LEU A 159
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.5A)
None
 0.69A 2yqzA-3anxA:
11.0		 2yqzA-3anxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A  87
ASP A 110
ALA A 141
LEU A 159
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.5A)
None
 0.66A 2yqzB-3anxA:
11.1		 2yqzB-3anxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
GLY A  87
ILE A 109
ASP A 110
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-4.3A)
 0.96A 2zbpA-3anxA:
11.7		 2zbpA-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 10 GLY A  87
ASP A 108
ILE A 109
ASP A 140
LEU A 159
 MTA  A 315 (-4.0A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
MTA  A 315 (-3.9A)
None
 0.89A 3ay0B-3anxA:
2.3		 3ay0B-3anxA:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLN A  54
TYR A  63
HIS A  64
ASP A 158
GLN A 194
 MTA  A 315 (-2.4A)
None
None
MTA  A 315 (-4.9A)
None
 0.87A 3b7pA-3anxA:
35.6		 3b7pA-3anxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLN A  54
TYR A  63
HIS A  64
ASP A 158
ILE A 227
 MTA  A 315 (-2.4A)
None
None
MTA  A 315 (-4.9A)
None
 1.33A 3b7pA-3anxA:
35.6		 3b7pA-3anxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 TYR A  63
HIS A  64
ASP A 158
ASP A 161
GLN A 194
 None
None
MTA  A 315 (-4.9A)
None
None
 1.00A 3b7pA-3anxA:
35.6		 3b7pA-3anxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLN A  54
TYR A  63
HIS A  64
ASP A 158
GLN A 194
 MTA  A 315 (-2.4A)
None
None
MTA  A 315 (-4.9A)
None
 0.81A 3b7pB-3anxA:
35.1		 3b7pB-3anxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 TYR A  63
HIS A  64
ASP A 158
ASP A 161
GLN A 194
 None
None
MTA  A 315 (-4.9A)
None
None
 0.97A 3b7pB-3anxA:
35.1		 3b7pB-3anxA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		7 / 12 GLN A  33
TYR A  63
HIS A  64
GLY A  85
ILE A 109
ASP A 110
ASP A 140
 MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-3.2A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-3.9A)
 0.57A 3bwcA-3anxA:
32.3		 3bwcA-3anxA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 TYR A  63
HIS A  64
GLY A  85
ILE A 109
GLN A 194
 None
None
MTA  A 315 (-3.2A)
MTA  A 315 (-3.7A)
None
 0.88A 3bwcA-3anxA:
32.3		 3bwcA-3anxA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_1
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 4 LEU A  49
GLN A  54
ASP A 108
ASP A 158
 MTA  A 315 ( 4.4A)
MTA  A 315 (-2.4A)
MTA  A 315 (-3.3A)
MTA  A 315 (-4.9A)
 1.02A 3bwcA-3anxA:
32.3		 3bwcA-3anxA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		7 / 12 LEU A  49
TYR A  63
HIS A  64
GLY A  85
ILE A 109
ASP A 110
ASP A 158
 MTA  A 315 ( 4.4A)
None
None
MTA  A 315 (-3.2A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-4.9A)
 0.50A 3bwcB-3anxA:
32.0		 3bwcB-3anxA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A  49
TYR A  63
HIS A  64
ILE A 157
ASP A 158
 MTA  A 315 ( 4.4A)
None
None
None
MTA  A 315 (-4.9A)
 0.94A 3bwcB-3anxA:
32.0		 3bwcB-3anxA:
34.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLN A  33
GLN A  54
ASP A 108
ASP A 140
 MTA  A 315 (-3.7A)
MTA  A 315 (-2.4A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
 0.90A 3bwcB-3anxA:
32.0		 3bwcB-3anxA:
34.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
ASP A 108
ILE A 109
ASP A 110
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-4.3A)
 0.94A 3cjtC-3anxA:
11.7		 3cjtC-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
GLY A  87
ILE A 109
ASP A 110
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-4.3A)
 0.92A 3cjtG-3anxA:
11.5		 3cjtG-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
ILE A 109
ASP A 110
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-4.3A)
 0.87A 3cjtK-3anxA:
11.9		 3cjtK-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
GLY A  87
ILE A 109
ASP A 110
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-4.3A)
 0.92A 3cjtO-3anxA:
11.8		 3cjtO-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 HIS A 203
GLY A 235
GLY A 196
LEU A 232
LEU A 278
 None
 0.97A 3cjtO-3anxA:
11.8		 3cjtO-3anxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 ASP A 108
ASP A 140
ASP A 158
 MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.9A)
 0.76A 3douA-3anxA:
10.4		 3douA-3anxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 VAL A  84
GLY A  85
GLY A  87
ASP A 110
ASP A 140
ALA A 141
 None
MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
 0.57A 3fuuA-3anxA:
10.4		 3fuuA-3anxA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 11 GLY A  85
GLY A  87
ILE A 109
ASP A 110
ASP A 140
ALA A 141
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
 0.86A 3grvA-3anxA:
10.8		 3grvA-3anxA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 11 GLY A  85
ILE A 109
ASP A 110
LEU A 113
ASP A 140
ALA A 141
 MTA  A 315 (-3.2A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
 0.91A 3grvA-3anxA:
10.8		 3grvA-3anxA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		7 / 12 GLY A  85
GLY A  87
ILE A 109
ASP A 110
LEU A 113
ASP A 140
ALA A 141
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.7A)
None
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
 1.27A 3gryA-3anxA:
10.7		 3gryA-3anxA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A  87
GLY A  89
ASP A 140
LEU A 159
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.9A)
None
 0.87A 3ihtA-3anxA:
10.5		 3ihtA-3anxA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A  87
GLY A  89
THR A  91
LEU A 159
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
None
None
 0.72A 3ihtA-3anxA:
10.5		 3ihtA-3anxA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 6 ARG A 256
SER A 249
ASP A 244
PRO A  76
 None
 1.49A 3jqaB-3anxA:
5.5		 3jqaB-3anxA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 6 PHE A  43
PHE A 231
THR A  56
VAL A  46
 None
 1.03A 3lb3B-3anxA:
undetectable		 3lb3B-3anxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLN A  54
GLU A  88
THR A 160
GLY A  85
GLY A  87
 MTA  A 315 (-2.4A)
None
MTA  A 315 (-3.6A)
MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
 1.12A 3tegA-3anxA:
undetectable		 3tegA-3anxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 8 THR A  74
PRO A  76
GLY A 188
PHE A 243
 None
 1.08A 3tzfB-3anxA:
undetectable		 3tzfB-3anxA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 ASP A  59
SER A  55
GLU A  65
HIS A  64
 None
 1.30A 4aq7A-3anxA:
undetectable		 4aq7A-3anxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLN A  33
ASP A 108
ASP A 110
ALA A 141
ASP A 158
 MTA  A 315 (-3.7A)
MTA  A 315 (-3.3A)
None
MTA  A 315 (-3.5A)
MTA  A 315 (-4.9A)
 1.06A 4dmgA-3anxA:
11.1		 4dmgA-3anxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 8 VAL A  53
PHE A 234
ILE A 227
PHE A 236
 None
 0.86A 4fglD-3anxA:
2.6		 4fglD-3anxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 VAL A  53
PHE A 234
ILE A 227
PHE A 236
 None
 0.85A 4fglC-3anxA:
2.9		 4fglC-3anxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 TYR A  61
ARG A  93
HIS A  64
 None
 1.08A 4fubA-3anxA:
undetectable		 4fubA-3anxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
GLY A  87
ASP A 108
ILE A 109
ASP A 140
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.3A)
 0.77A 4iv8A-3anxA:
11.5		 4iv8A-3anxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
GLY A  87
ASP A 108
ILE A 109
ASP A 140
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
MTA  A 315 (-3.9A)
MTA  A 315 (-4.3A)
 0.78A 4iv8B-3anxA:
11.8		 4iv8B-3anxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 11 SER A  55
GLY A  85
GLY A  86
ASP A 108
ASP A 140
 None
MTA  A 315 (-3.2A)
MTA  A 315 (-4.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
 1.05A 4pghA-3anxA:
10.9		 4pghA-3anxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 SER A  55
ASP A 158
GLY A  85
ASP A 108
ASP A 140
 None
MTA  A 315 (-4.9A)
MTA  A 315 (-3.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
 1.39A 4pghB-3anxA:
10.6		 4pghB-3anxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 SER A  55
GLY A  85
GLY A  86
ASP A 108
ASP A 140
 None
MTA  A 315 (-3.2A)
MTA  A 315 (-4.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.9A)
 1.15A 4pghD-3anxA:
3.9		 4pghD-3anxA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 7 ILE A  62
HIS A  98
LEU A 262
LEU A 264
 None
 1.02A 4xo7A-3anxA:
undetectable		 4xo7A-3anxA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 6 ILE A 227
HIS A  10
ILE A  48
VAL A  46
 None
 0.91A 4zj8A-3anxA:
undetectable		 4zj8A-3anxA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		3 / 3 VAL A 301
HIS A 206
VAL A 209
 None
 0.66A 5jmnC-3anxA:
undetectable		 5jmnC-3anxA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 4 GLU A  94
THR A  91
GLU A  88
HIS A 120
 None
 1.49A 5utuF-3anxA:
4.2		 5utuF-3anxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
GLY A  87
ASP A 108
ILE A 109
LEU A 159
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-4.3A)
 1.08A 5wy0A-3anxA:
11.1		 5wy0A-3anxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		9 / 12 GLN A  33
GLY A  85
ASP A 108
ILE A 109
ASP A 110
ASP A 140
ALA A 141
LEU A 159
LEU A 172
 MTA  A 315 (-3.7A)
MTA  A 315 (-3.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
None
MTA  A 315 (-4.3A)
 0.57A 6bq4A-3anxA:
40.3		 6bq4A-3anxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		7 / 12 GLY A  85
ASP A 108
ILE A 109
VAL A 114
ASP A 140
ALA A 141
LEU A 172
 MTA  A 315 (-3.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
MTA  A 315 (-4.3A)
 1.21A 6bq4A-3anxA:
40.3		 6bq4A-3anxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		8 / 12 GLN A  33
GLY A  85
ASP A 108
ILE A 109
ASP A 110
ASP A 140
ALA A 141
LEU A 159
 MTA  A 315 (-3.7A)
MTA  A 315 (-3.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
None
 0.43A 6bq4B-3anxA:
40.4		 6bq4B-3anxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		6 / 12 GLY A  85
ASP A 108
ILE A 109
VAL A 114
ASP A 140
ALA A 141
 MTA  A 315 (-3.2A)
MTA  A 315 (-3.3A)
MTA  A 315 (-3.7A)
None
MTA  A 315 (-3.9A)
MTA  A 315 (-3.5A)
 1.20A 6bq4B-3anxA:
40.4		 6bq4B-3anxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLU A   9
VAL A  11
LEU A 232
HIS A 226
 None
 1.50A 6dyoA-3anxA:
2.8		 6dyoA-3anxA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3anx SPERMIDINE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  85
GLY A  87
ALA A  90
ILE A 109
ASP A 110
 MTA  A 315 (-3.2A)
MTA  A 315 (-4.0A)
None
MTA  A 315 (-3.7A)
None
 0.60A 6iftA-3anxA:
9.5		 6iftA-3anxA:
23.58