SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3any'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 ASP A 214
ASP A 207
GLY A 241
THR A 220
ILE A 213
 None
 1.00A 1fb7A-3anyA:
undetectable		 1fb7A-3anyA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 10 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.12A 1fk9A-3anyA:
undetectable		 1fk9A-3anyA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 PHE A 275
GLY A 241
LEU A 206
VAL A 199
 None
 0.96A 1gsfC-3anyA:
undetectable		 1gsfC-3anyA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 9 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.18A 1ikvA-3anyA:
undetectable		 1ikvA-3anyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 10 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.10A 1ikwA-3anyA:
undetectable		 1ikwA-3anyA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 GLY A 272
VAL A 271
GLU A 274
ILE A 244
 None
 0.79A 1pk7B-3anyA:
undetectable		 1pk7B-3anyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 5 LEU B 225
PRO B 199
VAL B 163
ILE B 165
 None
 0.96A 2aoiB-3anyB:
undetectable		 2aoiB-3anyB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 ASN A 376
ASP A 399
GLY A 328
VAL A 326
ASP A 362
 None
None
None
2A3  A 602 (-4.7A)
2A3  A 602 (-3.8A)
 1.29A 2fqyA-3anyA:
undetectable		 2fqyA-3anyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 TYR A 390
VAL A 143
ALA A 315
PHE A 286
TYR A 285
 None
 1.26A 2g70B-3anyA:
undetectable		 2g70B-3anyA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 10 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.18A 2hndA-3anyA:
undetectable		 2hndA-3anyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		4 / 7 ALA B 173
SER B 170
SER B 237
ASN A 403
 None
None
None
B12  B 601 ( 4.2A)
 0.87A 2i91A-3anyB:
3.5		 2i91A-3anyB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		4 / 7 ALA B 173
SER B 170
SER B 237
ASN A 403
 None
None
None
B12  B 601 ( 4.2A)
 0.87A 2i91B-3anyB:
3.2		 2i91B-3anyB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 7 TYR A 404
PHE A 329
ASP A 362
GLU A 287
 None
2A3  A 602 (-3.8A)
2A3  A 602 (-3.8A)
2A3  A 602 (-2.7A)
 1.09A 2qebA-3anyA:
undetectable		 2qebA-3anyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 7 TYR A 404
PHE A 329
ASP A 362
GLU A 287
 None
2A3  A 602 (-3.8A)
2A3  A 602 (-3.8A)
2A3  A 602 (-2.7A)
 1.07A 2qebB-3anyA:
undetectable		 2qebB-3anyA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		3 / 3 PRO A 194
ASN A 201
ARG A 204
 B12  B 601 (-4.9A)
None
None
 0.98A 2qeuB-3anyA:
undetectable		 2qeuB-3anyA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 6 ARG B  77
ILE A 400
ILE A 209
LEU A 225
 None
None
None
2A3  A 602 ( 4.6A)
 0.97A 2xkwB-3anyB:
undetectable		 2xkwB-3anyB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		3 / 3 THR A 113
SER A 106
LYS A 140
 None
 1.11A 3aocC-3anyA:
undetectable		 3aocC-3anyA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		5 / 11 VAL B 207
LEU B 224
ILE B 259
SER B 260
SER B 237
 B12  B 601 (-3.6A)
None
None
B12  B 601 (-3.2A)
None
 1.33A 3bjwH-3anyB:
undetectable		 3bjwH-3anyB:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		4 / 8 LEU A 396
SER A 182
GLY B  84
PRO B  85
 None
 0.95A 3hcrA-3anyA:
undetectable		 3hcrA-3anyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		3 / 3 ILE B 174
SER B 239
SER B 237
 None
B12  B 601 ( 4.6A)
None
 0.58A 3iltH-3anyB:
undetectable		 3iltH-3anyB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		5 / 12 TYR B 133
HIS A 368
THR A 366
ASP B 138
LEU A 335
 None
 1.15A 3lcvB-3anyB:
undetectable		 3lcvB-3anyB:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 9 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.19A 3lp0A-3anyA:
undetectable		 3lp0A-3anyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 10 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.15A 3lp1A-3anyA:
undetectable		 3lp1A-3anyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		5 / 10 VAL B 226
LEU B 224
SER B 239
GLY B 168
GLY B 205
 None
None
B12  B 601 ( 4.6A)
B12  B 601 ( 4.3A)
None
 0.96A 3ls4H-3anyB:
undetectable		 3ls4H-3anyB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.14A 3mecA-3anyA:
undetectable		 3mecA-3anyA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.15A 3medA-3anyA:
0.8
3medB-3anyA:
undetectable		 3medA-3anyA:
21.39
3medB-3anyA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 8 LEU B 182
ALA B 274
GLY B 197
PRO B 199
 None
 0.93A 3ny4A-3anyB:
undetectable		 3ny4A-3anyB:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 ALA A 296
GLY A 289
GLY A 291
ILE A 330
ASP A 362
 None
None
None
B12  B 601 (-4.3A)
2A3  A 602 (-3.8A)
 1.04A 3o7wA-3anyA:
undetectable		 3o7wA-3anyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 ALA A 296
GLY A 289
GLY A 291
PHE A 329
ILE A 330
 None
None
None
2A3  A 602 (-3.8A)
B12  B 601 (-4.3A)
 0.97A 3o7wA-3anyA:
undetectable		 3o7wA-3anyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 SER A 172
ARG A 160
ASP A 399
THR A 166
 None
2A3  A 602 (-3.0A)
None
None
 1.39A 3okxA-3anyA:
0.0		 3okxA-3anyA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_2
(YAEB-LIKE PROTEIN
RPA0152)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 SER A 172
ARG A 160
ASP A 399
THR A 166
 None
2A3  A 602 (-3.0A)
None
None
 1.41A 3okxB-3anyA:
0.0		 3okxB-3anyA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 7 MET A 394
ILE A 190
VAL A 189
ARG A 160
 None
None
None
2A3  A 602 (-3.0A)
 0.95A 3p6hA-3anyA:
undetectable		 3p6hA-3anyA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 ASN A 193
TYR A 404
LEU A 402
PHE A 329
 2A3  A 602 ( 3.1A)
None
B12  B 601 (-4.5A)
2A3  A 602 (-3.8A)
 1.10A 3rqwC-3anyA:
undetectable
3rqwD-3anyA:
undetectable		 3rqwC-3anyA:
20.76
3rqwD-3anyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 TYR A 404
LEU A 402
PHE A 329
ASN A 193
 None
B12  B 601 (-4.5A)
2A3  A 602 (-3.8A)
2A3  A 602 ( 3.1A)
 1.13A 3rqwF-3anyA:
undetectable
3rqwJ-3anyA:
undetectable		 3rqwF-3anyA:
20.76
3rqwJ-3anyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		6 / 9 ASP A 214
ILE A 209
GLY A 242
ILE A 278
ILE A 218
ILE A 213
 None
 1.49A 3s45A-3anyA:
undetectable		 3s45A-3anyA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 9 ILE A 218
LEU A 181
ILE A 209
MET A 394
GLY A 393
 None
 1.27A 3sj4X-3anyA:
undetectable		 3sj4X-3anyA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		3 / 3 ARG A  44
LYS A  48
ARG A 343
 None
 1.33A 3w1wA-3anyA:
undetectable
3w1wB-3anyA:
undetectable		 3w1wA-3anyA:
21.48
3w1wB-3anyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		3 / 3 ARG A 343
ARG A  44
LYS A  48
 None
 1.47A 3w1wA-3anyA:
undetectable
3w1wB-3anyA:
1.5		 3w1wA-3anyA:
21.48
3w1wB-3anyA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 SER A 433
MET A 437
PHE A 427
GLU A 432
 None
 1.27A 4cx7A-3anyA:
undetectable
4cx7B-3anyA:
undetectable		 4cx7A-3anyA:
23.45
4cx7B-3anyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 4 ALA A 344
VAL A 327
ASP A 348
LEU A 383
 None
 1.33A 4e7gA-3anyA:
undetectable		 4e7gA-3anyA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 6 GLY A 241
GLY A 242
ASN A 148
ILE A 244
 None
 0.99A 4fglD-3anyA:
undetectable		 4fglD-3anyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.17A 4lvcA-3anyA:
undetectable		 4lvcA-3anyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.16A 4lvcC-3anyA:
undetectable		 4lvcC-3anyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 6 LEU A 402
ASP A 168
VAL B  75
ALA B  76
 B12  B 601 (-4.5A)
None
None
None
 1.02A 4nkxA-3anyA:
undetectable		 4nkxA-3anyA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 TYR A 178
GLY A 180
SER A 182
ILE A 190
GLY A 191
 None
 1.30A 4obwC-3anyA:
undetectable		 4obwC-3anyA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		3 / 3 LEU A 346
MET A 351
TYR A 136
 None
 0.93A 4p6xG-3anyA:
undetectable		 4p6xG-3anyA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU B  70
VAL B  78
PRO A 449
PHE A 216
GLY A 435
 None
 1.33A 4q15A-3anyB:
6.1		 4q15A-3anyB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU B  70
VAL B  78
PRO A 449
PHE A 216
GLY A 435
 None
 1.32A 4q15B-3anyB:
5.3		 4q15B-3anyB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 GLY A 345
GLU A 308
ALA A 309
MET A 351
 None
 0.87A 4rjdA-3anyA:
undetectable
4rjdB-3anyA:
undetectable		 4rjdA-3anyA:
11.68
4rjdB-3anyA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		3 / 3 VAL A 323
TYR A 312
ALA A 315
 None
 0.52A 4ybnA-3anyA:
undetectable		 4ybnA-3anyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 TYR A 285
LEU A 225
MET A 392
GLN A 162
 None
2A3  A 602 ( 4.6A)
2A3  A 602 (-3.6A)
2A3  A 602 (-3.4A)
 1.40A 4yo9A-3anyA:
0.0
4yo9B-3anyA:
0.0		 4yo9A-3anyA:
21.75
4yo9B-3anyA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 7 VAL A 260
GLN A 246
LEU A 265
GLU A 267
 None
B12  B 601 (-2.9A)
None
None
 0.84A 4zphA-3anyA:
undetectable
4zphB-3anyA:
undetectable		 4zphA-3anyA:
21.89
4zphB-3anyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 7 VAL A 323
ASN A 324
ILE A 322
PHE A 321
ILE A 248
 None
2A3  A 602 ( 4.9A)
None
None
None
 1.41A 5bmvC-3anyA:
undetectable		 5bmvC-3anyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli) 		4 / 4 TYR B 133
GLY B 227
SER B 170
LEU B 169
 None
None
None
B12  B 601 ( 4.4A)
 1.45A 5bphC-3anyB:
undetectable		 5bphC-3anyB:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 4 LEU A 243
ILE A 244
GLY A 222
ILE A 235
 None
 0.82A 5dzk3-3anyA:
undetectable
5dzkm-3anyA:
undetectable		 5dzk3-3anyA:
0.52
5dzkm-3anyA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 ILE A 244
GLY A 222
ILE A 235
LEU A 243
 None
 0.83A 5dzkB-3anyA:
1.6
5dzkI-3anyA:
undetectable
5dzkW-3anyA:
undetectable		 5dzkB-3anyA:
19.69
5dzkI-3anyA:
19.02
5dzkW-3anyA:
0.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 ILE A 244
GLY A 222
ILE A 235
LEU A 243
 None
 0.88A 5dzki-3anyA:
undetectable
5dzkj-3anyA:
undetectable
5dzkx-3anyA:
undetectable		 5dzki-3anyA:
19.02
5dzkj-3anyA:
19.02
5dzkx-3anyA:
0.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 ILE A 244
GLY A 222
ILE A 235
LEU A 243
 None
 0.88A 5dzkd-3anyA:
1.5
5dzkk-3anyA:
undetectable
5dzky-3anyA:
undetectable		 5dzkd-3anyA:
19.69
5dzkk-3anyA:
19.02
5dzky-3anyA:
0.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU B  70
VAL B  78
PRO A 449
PHE A 216
GLY A 435
 None
 1.31A 5f9zA-3anyB:
4.8		 5f9zA-3anyB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU B  70
VAL B  78
PRO A 449
PHE A 216
GLY A 435
 None
 1.28A 5f9zB-3anyB:
5.1		 5f9zB-3anyB:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 8 ILE A 436
LEU A 161
ILE A 190
LEU A 442
 None
 0.84A 5ieoA-3anyA:
undetectable		 5ieoA-3anyA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 4 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.16A 5m5kA-3anyA:
undetectable		 5m5kA-3anyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 4 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.16A 5m5kC-3anyA:
undetectable		 5m5kC-3anyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 4 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.19A 5m66B-3anyA:
undetectable		 5m66B-3anyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN
(Escherichia
coli;
Escherichia
coli) 		5 / 12 LEU B  70
VAL B  78
PRO A 449
PHE A 216
GLY A 435
 None
 1.26A 5xiqA-3anyB:
5.8		 5xiqA-3anyB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.10A 5yn6A-3anyA:
undetectable		 5yn6A-3anyA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.07A 5yniA-3anyA:
undetectable		 5yniA-3anyA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 12 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.09A 5ynmA-3anyA:
undetectable		 5ynmA-3anyA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 10 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.17A 6bsgA-3anyA:
undetectable		 6bsgA-3anyA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 10 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.22A 6bsiA-3anyA:
undetectable		 6bsiA-3anyA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		5 / 10 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.19A 6bsjA-3anyA:
undetectable		 6bsjA-3anyA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 4 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.22A 6f3mB-3anyA:
undetectable		 6f3mB-3anyA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.20A 6gbnA-3anyA:
undetectable		 6gbnA-3anyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN
(Escherichia
coli) 		4 / 5 GLN A 405
THR A 366
THR A 325
LEU A 379
 None
 1.20A 6gbnD-3anyA:
undetectable		 6gbnD-3anyA:
22.29