SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aoe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU E 139
TYR E 135
GLY E 114
GLY E  79
ALA E 112
 None
 1.06A 1httC-3aoeE:
2.5		 1httC-3aoeE:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR E 249
GLY E 230
TYR E 269
GLY E 227
ALA E 297
 None
 0.98A 1httC-3aoeE:
2.5		 1httC-3aoeE:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU E 139
TYR E 135
GLY E 114
GLY E  79
ALA E 112
 None
 1.12A 1httD-3aoeE:
undetectable		 1httD-3aoeE:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A  67
THR A 157
VAL A  81
 None
 0.91A 1hxbA-3aoeA:
undetectable		 1hxbA-3aoeA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 GLY A 353
PHE A 359
LEU A 379
SER A 191
ARG A 194
 None
 1.49A 1jhqA-3aoeA:
2.5		 1jhqA-3aoeA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 GLY A 353
PHE A 359
LEU A 379
SER A 191
ARG A 194
 None
 1.49A 1jhvA-3aoeA:
2.4		 1jhvA-3aoeA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TRP E  97
ARG E 397
GLY E 322
ASP E 341
 None
 1.23A 1kf6M-3aoeE:
undetectable
1kf6N-3aoeE:
undetectable		 1kf6M-3aoeE:
23.66
1kf6N-3aoeE:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY E  78
VAL E  80
ALA E 102
GLY E 182
SER E 352
 None
 1.08A 1kiaA-3aoeE:
4.2		 1kiaA-3aoeE:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE E 164
GLY E  78
VAL E  80
GLY E 182
SER E 352
 None
 1.01A 1kiaA-3aoeE:
4.2		 1kiaA-3aoeE:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU E 323
GLU E 317
ALA E 201
GLY E 200
ARG E 397
 None
 1.29A 1l5rA-3aoeE:
undetectable		 1l5rA-3aoeE:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 LEU E 332
GLU E 328
LEU E 323
GLU E 317
 None
 1.07A 1linA-3aoeE:
undetectable		 1linA-3aoeE:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 GLU E 375
ARG E 371
LEU E 203
GLU E 206
ALA E 207
 None
 1.03A 1mjoA-3aoeE:
undetectable		 1mjoA-3aoeE:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY E  78
VAL E  80
ALA E 102
GLY E 182
SER E 352
 None
 1.15A 1nbiA-3aoeE:
4.4		 1nbiA-3aoeE:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE E 164
GLY E  78
VAL E  80
GLY E 182
SER E 352
 None
 1.07A 1nbiA-3aoeE:
4.4		 1nbiA-3aoeE:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY E  78
VAL E  80
ALA E 102
GLY E 182
SER E 352
 None
 1.14A 1nbiB-3aoeE:
4.3		 1nbiB-3aoeE:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE E 164
GLY E  78
VAL E  80
GLY E 182
SER E 352
 None
 1.06A 1nbiB-3aoeE:
4.3		 1nbiB-3aoeE:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU A 161
TRP A 164
LYS A 102
 None
 1.26A 1qu2A-3aoeA:
undetectable		 1qu2A-3aoeA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA E 232
LEU E 199
GLY E 200
GLY E 348
 None
 0.87A 1rukH-3aoeE:
undetectable
1rukL-3aoeE:
undetectable		 1rukH-3aoeE:
17.66
1rukL-3aoeE:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 SER E 344
GLY E 345
ARG E 397
 None
 0.67A 1t9wA-3aoeE:
2.9		 1t9wA-3aoeE:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLU E 368
GLU E 375
LEU E 354
 None
 0.72A 1v8bA-3aoeE:
2.5		 1v8bA-3aoeE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU E 349
SER E 352
TYR E 353
LEU E 107
 None
 1.30A 1xz1A-3aoeE:
undetectable		 1xz1A-3aoeE:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 LEU E 349
SER E 352
TYR E 353
LEU E 107
 None
 1.30A 1xz3A-3aoeE:
undetectable		 1xz3A-3aoeE:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ILE A 348
ALA A 405
ASN A 385
ALA A 404
ILE A 204
 None
 1.18A 2aclC-3aoeA:
undetectable		 2aclC-3aoeA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 SER E 352
ASP E 153
ARG E  81
ASP E  83
 None
 1.45A 2bm9C-3aoeE:
1.7		 2bm9C-3aoeE:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE E 164
LEU E  50
LEU E  48
LEU E 139
ARG E  66
 None
 1.17A 2bxfA-3aoeE:
undetectable		 2bxfA-3aoeE:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LEU A 383
PHE A 359
VAL A 106
ALA A 351
 None
 1.14A 2cizA-3aoeA:
undetectable		 2cizA-3aoeA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 TYR E  18
GLY E 111
THR E  99
ALA E  96
ALA E  95
 None
 1.29A 2ej3C-3aoeE:
undetectable		 2ej3C-3aoeE:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A 303
VAL A 246
ILE A 224
ARG A 316
 None
 0.97A 2hyyA-3aoeA:
undetectable		 2hyyA-3aoeA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 PRO E 184
ALA E 162
ASP E 194
ASP E 157
 None
 1.17A 2nyuB-3aoeE:
5.6		 2nyuB-3aoeE:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 346
ASN A 350
THR A 355
 None
 0.71A 2q63B-3aoeA:
undetectable		 2q63B-3aoeA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ARG A  67
THR A 157
VAL A  81
 None
 0.98A 2qakA-3aoeA:
undetectable		 2qakA-3aoeA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A 324
ALA A 234
GLY A 199
GLY A 231
ILE A 224
 None
 1.00A 2v7bB-3aoeA:
5.8		 2v7bB-3aoeA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU E 293
ALA E 296
LEU E 295
ALA E 301
PHE E 286
 None
 1.14A 2vcvD-3aoeE:
undetectable		 2vcvD-3aoeE:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 LEU E 293
ALA E 296
LEU E 295
ALA E 301
PHE E 286
 None
 1.13A 2vcvI-3aoeE:
undetectable		 2vcvI-3aoeE:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 140
GLY A 141
GLY A 145
HIS A  69
ARG A  45
 None
 0.71A 2y7kC-3aoeA:
undetectable		 2y7kC-3aoeA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR E  38
VAL E 417
THR E  35
 LEU  E 500 (-4.4A)
LEU  E 500 (-3.8A)
None
 0.78A 2ygnA-3aoeE:
undetectable		 2ygnA-3aoeE:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TRP E  97
VAL E  31
ARG E 413
 None
 0.92A 3b0wA-3aoeE:
undetectable		 3b0wA-3aoeE:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 VAL A 408
VAL A 407
PHE A 387
ARG A  25
 None
 1.23A 3bjwH-3aoeA:
0.1		 3bjwH-3aoeA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3aoe GLUTAMATE
DEHYDROGENASE
GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus;
Thermus
thermophilus) 		5 / 12 PHE E 109
LEU A 188
GLY A 189
ASP E 148
ILE E 149
 None
 1.04A 3eeoA-3aoeE:
3.8		 3eeoA-3aoeE:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 VAL E 382
CYH E 386
ALA E 389
LEU E 394
LEU E 403
VAL E 204
 None
 1.29A 3fc6C-3aoeE:
undetectable		 3fc6C-3aoeE:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 VAL E 382
CYH E 386
ALA E 389
LEU E 403
ALA E 402
VAL E 204
 None
 1.30A 3fc6C-3aoeE:
undetectable		 3fc6C-3aoeE:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A 399
ALA A 404
LEU A 401
ILE A 307
LEU A 336
 None
 1.05A 3mb5A-3aoeA:
undetectable		 3mb5A-3aoeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY E 322
GLY E 300
GLN E 224
ALA E 319
ASN E 320
 None
 1.32A 3t7sB-3aoeE:
4.4		 3t7sB-3aoeE:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLY A 190
PRO A 185
GLY A 158
THR A 157
 None
 0.86A 3tajA-3aoeA:
undetectable		 3tajA-3aoeA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A 205
LEU A 383
LEU A 379
GLY A 352
VAL A 230
 None
 1.42A 4c9kA-3aoeA:
undetectable		 4c9kA-3aoeA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A 205
LEU A 383
LEU A 379
GLY A 352
VAL A 230
 None
 1.38A 4c9pA-3aoeA:
undetectable		 4c9pA-3aoeA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ALA A 410
ALA A  34
PRO A  35
LEU A 414
 None
 1.12A 4dtzB-3aoeA:
undetectable		 4dtzB-3aoeA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 PRO E  42
GLY E  89
ALA E  96
GLN E  63
 None
 1.09A 4g0uA-3aoeE:
3.0		 4g0uA-3aoeE:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 106
TYR A 110
ILE A 150
GLY A  79
SER A 357
 None
 1.05A 4iv0A-3aoeA:
3.8		 4iv0A-3aoeA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ARG A 402
VAL A 106
GLY A 201
VAL A 347
ILE A 348
 None
 1.20A 4ll3B-3aoeA:
undetectable		 4ll3B-3aoeA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ASP E 153
VAL E 229
GLY E 348
ALA E 296
 None
 0.90A 4m48A-3aoeE:
undetectable		 4m48A-3aoeE:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 LEU E 150
ILE E 143
LEU E 142
ARG E  66
 None
 0.83A 4mghA-3aoeE:
3.0		 4mghA-3aoeE:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL A 106
TYR A 110
ILE A 150
GLY A  79
SER A 357
 None
 1.05A 4mwzB-3aoeA:
3.7		 4mwzB-3aoeA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A 394
THR A 205
ALA A 209
ILE A 213
ILE A 319
 None
 1.12A 4o2bB-3aoeA:
undetectable		 4o2bB-3aoeA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR A 169
GLY A 145
PRO A 146
 None
 0.62A 4qwpA-3aoeA:
undetectable		 4qwpA-3aoeA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR E 168
GLY E 144
PRO E 145
 None
 0.59A 4qwpA-3aoeE:
undetectable		 4qwpA-3aoeE:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 7 LEU E 295
LEU E 293
ALA E 312
ALA E 336
LEU E 323
 None
 1.48A 4z90F-3aoeE:
undetectable
4z90G-3aoeE:
undetectable
4z90H-3aoeE:
undetectable
4z90J-3aoeE:
undetectable		 4z90F-3aoeE:
21.48
4z90G-3aoeE:
21.48
4z90H-3aoeE:
21.48
4z90J-3aoeE:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 ALA E 402
VAL E  28
GLY E 399
ALA E 389
GLY E 392
 None
 1.30A 4zjzB-3aoeE:
5.3		 4zjzB-3aoeE:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLY A 158
ILE A 186
SER A 191
GLY A 183
 None
 0.77A 5alcL-3aoeA:
undetectable		 5alcL-3aoeA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ARG E 308
ASP E 305
LEU E 302
LEU E 331
GLU E 326
 None
 1.25A 5dqfA-3aoeE:
undetectable		 5dqfA-3aoeE:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU E 139
TYR E 135
GLY E 114
GLY E  79
ALA E 112
 None
 1.00A 5e3iA-3aoeE:
undetectable		 5e3iA-3aoeE:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR E 249
GLY E 230
TYR E 269
GLY E 227
ALA E 297
 None
 1.04A 5e3iA-3aoeE:
undetectable		 5e3iA-3aoeE:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLN E 224
GLY E 230
TYR E 269
GLY E 227
ALA E 297
 None
 1.35A 5e3iB-3aoeE:
undetectable		 5e3iB-3aoeE:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_B_HISB502_0
(HISTIDINE--TRNA
LIGASE)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 THR E 249
GLY E 230
TYR E 269
GLY E 227
ALA E 297
 None
 1.04A 5e3iB-3aoeE:
undetectable		 5e3iB-3aoeE:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 VAL E 382
ASP E 383
LEU E 214
LEU E 205
LEU E 216
 None
 1.20A 5hnyB-3aoeE:
undetectable		 5hnyB-3aoeE:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLU E 317
LEU E 107
ARG E 397
PRO E 340
LEU E 343
 None
 1.23A 5nd2B-3aoeE:
undetectable		 5nd2B-3aoeE:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ARG E  81
ALA E 113
VAL E  67
GLY E  93
 None
 0.99A 5v0vA-3aoeE:
1.4		 5v0vA-3aoeE:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ALA A 394
VAL A  26
TYR A  29
 None
 0.47A 5zmqH-3aoeA:
undetectable		 5zmqH-3aoeA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 3aoe GLUTAMATE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL E 222
LEU E 275
GLY E 287
GLY E 252
 None
 0.78A 6eu9D-3aoeE:
undetectable		 6eu9D-3aoeE:
12.53