SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		3 / 3 ALA A 210
VAL A 361
TRP A 350
 None
 1.00A 1gmkA-3aovA:
undetectable
1gmkB-3aovA:
undetectable		 1gmkA-3aovA:
2.46
1gmkB-3aovA:
2.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		4 / 8 TYR A 201
VAL A 234
GLY A 278
THR A 266
 None
None
None
PLP  A 429 (-3.1A)
 0.85A 2a1hA-3aovA:
undetectable
2a1hB-3aovA:
undetectable		 2a1hA-3aovA:
23.24
2a1hB-3aovA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		4 / 6 ILE A 270
TRP A 279
LEU A 103
ILE A 277
 None
 0.79A 2q83B-3aovA:
undetectable		 2q83B-3aovA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		4 / 7 ILE A 270
GLY A 356
GLY A 240
ARG A 326
 None
 0.79A 2wd9A-3aovA:
2.4		 2wd9A-3aovA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		5 / 12 LEU A 418
THR A 421
MET A 399
LEU A 373
ILE A 377
 None
 1.30A 2ydoA-3aovA:
undetectable		 2ydoA-3aovA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		6 / 12 LEU A 141
ILE A 136
LEU A 264
PRO A 204
PRO A 238
PHE A 161
 None
None
None
None
PLP  A 429 (-4.5A)
None
 1.33A 2ygqA-3aovA:
undetectable		 2ygqA-3aovA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		5 / 12 SER A 129
GLN A 130
ALA A 156
TYR A 239
ASN A 208
 PLP  A 429 (-3.8A)
None
None
PLP  A 429 (-4.4A)
PLP  A 429 (-3.7A)
 1.44A 5cxvA-3aovA:
0.0		 5cxvA-3aovA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		5 / 12 LEU A 401
ILE A 422
LEU A 340
ALA A 376
MET A 372
 None
 0.98A 5og9B-3aovA:
undetectable		 5og9B-3aovA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		3 / 3 GLU A  82
ARG A 311
TYR A  87
 None
 0.67A 5trqB-3aovA:
undetectable		 5trqB-3aovA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		3 / 3 ALA A 160
VAL A 234
TYR A 201
 None
 0.59A 5zmqH-3aovA:
undetectable		 5zmqH-3aovA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		4 / 7 LEU A 141
ILE A 136
TYR A 168
PHE A 161
 None
 1.03A 5zsfA-3aovA:
0.5
5zsfB-3aovA:
undetectable		 5zsfA-3aovA:
10.22
5zsfB-3aovA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		4 / 5 LEU A 318
LEU A 111
THR A 266
PRO A 204
 None
None
PLP  A 429 (-3.1A)
None
 1.06A 6ew0F-3aovA:
undetectable		 6ew0F-3aovA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		4 / 6 LEU A 318
LEU A 111
THR A 266
PRO A 204
 None
None
PLP  A 429 (-3.1A)
None
 1.06A 6ew0G-3aovA:
undetectable		 6ew0G-3aovA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3aov PUTATIVE
UNCHARACTERIZED
PROTEIN PH0207
(Pyrococcus
horikoshii) 		5 / 10 ILE A 359
VAL A 381
ALA A 376
LEU A  61
LEU A 340
 None
 0.95A 6f6nA-3aovA:
undetectable
6f6nB-3aovA:
undetectable		 6f6nA-3aovA:
11.09
6f6nB-3aovA:
10.80