SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3apm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 7 GLN A 286
THR A 268
SER A 270
GLN A 136
 None
 1.45A 1eiiA-3apmA:
undetectable		 1eiiA-3apmA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		5 / 11 VAL A 113
SER A 270
LEU A 199
THR A 187
THR A 189
 None
 1.18A 1pkvA-3apmA:
undetectable
1pkvB-3apmA:
undetectable		 1pkvA-3apmA:
11.09
1pkvB-3apmA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 8 LEU A 254
VAL A 227
LEU A 229
VAL A 203
 None
 1.02A 2bdmA-3apmA:
undetectable		 2bdmA-3apmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQ5_B_LDPB1197_1
(S-NORCOCLAURINE
SYNTHASE)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 7 LEU A 553
LEU A 557
LEU A 491
PRO A 414
 None
 0.93A 2vq5B-3apmA:
undetectable		 2vq5B-3apmA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 7 ILE A 565
ILE A 567
VAL A 616
LEU A 619
 None
 0.49A 3r9vA-3apmA:
undetectable
3r9vB-3apmA:
undetectable		 3r9vA-3apmA:
17.22
3r9vB-3apmA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 8 ALA A 204
VAL A 203
LEU A 267
LEU A 264
 None
 0.72A 3roxA-3apmA:
undetectable		 3roxA-3apmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 7 LEU A 620
LEU A 596
PRO A 599
ILE A 598
 None
 0.81A 3s56B-3apmA:
undetectable		 3s56B-3apmA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		3 / 3 ARG A 156
ASP A 179
GLN A 178
 None
 0.74A 4azsA-3apmA:
undetectable		 4azsA-3apmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 6 PHE A 214
GLY A 230
PRO A 231
VAL A 211
 None
 0.77A 4dubA-3apmA:
undetectable		 4dubA-3apmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 6 PHE A 214
GLY A 230
PRO A 231
VAL A 211
 None
 0.81A 4dubB-3apmA:
undetectable		 4dubB-3apmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		5 / 10 ILE A  42
LEU A  70
SER A  32
ILE A  94
THR A  67
 None
 1.27A 4g8zX-3apmA:
undetectable		 4g8zX-3apmA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		5 / 12 LEU A 462
LEU A 467
ASN A 588
ALA A 492
ILE A 546
 None
 1.12A 4o2bB-3apmA:
undetectable		 4o2bB-3apmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		5 / 12 GLN A 215
ALA A 216
HIS A 236
PHE A 249
LEU A 182
 None
 1.36A 4r7lA-3apmA:
undetectable		 4r7lA-3apmA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		5 / 12 LEU A 199
LEU A 185
MET A 247
HIS A 236
ILE A 269
 None
 1.12A 4x1gA-3apmA:
undetectable		 4x1gA-3apmA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		3 / 3 ARG A 212
ASN A 153
ASP A 157
 None
 0.91A 5gwxA-3apmA:
undetectable		 5gwxA-3apmA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3apm PROTEIN-ARGININE
DEIMINASE TYPE-4
(Homo
sapiens) 		4 / 5 VAL A 456
PRO A 424
GLY A 426
TYR A 423
 None
 1.23A 5x80A-3apmA:
undetectable
5x80B-3apmA:
undetectable		 5x80A-3apmA:
14.02
5x80B-3apmA:
14.02