SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3apo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 7 VAL A 369
LEU A 413
VAL A 415
LEU A 358
 None
 0.86A 1cqpA-3apoA:
undetectable
1cqpB-3apoA:
undetectable		 1cqpA-3apoA:
12.75
1cqpB-3apoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 6 PHE A 706
GLU A 709
LEU A 713
VAL A 692
 None
 1.02A 1hk1A-3apoA:
undetectable		 1hk1A-3apoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 7 PHE A 706
GLU A 709
LEU A 713
VAL A 692
 None
 0.95A 1hk2A-3apoA:
undetectable		 1hk2A-3apoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 12 GLY A 258
LEU A 347
ILE A 343
ILE A 261
LEU A 260
 None
 1.17A 1kyvA-3apoA:
undetectable
1kyvE-3apoA:
2.1		 1kyvA-3apoA:
12.08
1kyvE-3apoA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 12 ILE A 261
LEU A 260
GLY A 258
LEU A 347
ILE A 343
 None
 1.18A 1kyvB-3apoA:
undetectable
1kyvC-3apoA:
2.1		 1kyvB-3apoA:
12.08
1kyvC-3apoA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 12 ILE A 261
LEU A 260
GLY A 258
LEU A 347
ILE A 343
 None
 1.21A 1kyvC-3apoA:
2.1
1kyvD-3apoA:
undetectable		 1kyvC-3apoA:
12.08
1kyvD-3apoA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 12 ILE A 261
LEU A 260
GLY A 258
LEU A 347
ILE A 343
 None
 1.21A 1kyvD-3apoA:
undetectable
1kyvE-3apoA:
2.1		 1kyvD-3apoA:
12.08
1kyvE-3apoA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 11 SER A 450
PHE A 446
LEU A 413
VAL A 415
PHE A 371
 None
 1.24A 1q23F-3apoA:
undetectable		 1q23F-3apoA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0F_A_STRA1499_1
(CYTOCHROME P450 3A4)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 4 PHE A 371
ASP A 402
PHE A 373
VAL A 415
 None
 1.38A 1w0fA-3apoA:
undetectable		 1w0fA-3apoA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		3 / 3 PHE A 622
TYR A 637
TYR A 647
 None
 1.01A 1x70B-3apoA:
undetectable		 1x70B-3apoA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 11 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.09A 2iyfA-3apoA:
3.6		 2iyfA-3apoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 12 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.12A 2iyfB-3apoA:
3.5		 2iyfB-3apoA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		3 / 3 ARG A 661
ASN A 764
THR A 770
 None
 0.61A 2q63A-3apoA:
undetectable		 2q63A-3apoA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 7 ASP A 694
PHE A 706
TYR A 743
PRO A 744
 None
 1.32A 2q6kA-3apoA:
undetectable		 2q6kA-3apoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 6 LEU A 179
LEU A 178
ILE A 206
ARG A 208
 None
 1.02A 2rlfB-3apoA:
undetectable
2rlfC-3apoA:
undetectable		 2rlfB-3apoA:
6.37
2rlfC-3apoA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 9 LEU A 490
ALA A 493
LEU A 501
TYR A 537
THR A 526
 None
 1.36A 4ltwA-3apoA:
undetectable		 4ltwA-3apoA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 11 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.08A 4m83A-3apoA:
undetectable		 4m83A-3apoA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 11 ASN A 152
VAL A 151
PHE A 150
ASN A 217
ALA A 213
 None
 1.11A 4m83B-3apoA:
undetectable		 4m83B-3apoA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		3 / 3 ASP A 442
ARG A 491
PRO A 488
 None
 1.01A 4wanC-3apoA:
undetectable		 4wanC-3apoA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 10 GLN A 461
GLU A 430
LEU A 458
THR A 456
THR A 457
 None
 1.31A 5jn8D-3apoA:
undetectable		 5jn8D-3apoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		5 / 11 GLN A 461
GLU A 430
LEU A 458
THR A 456
THR A 457
 None
 1.29A 5jncA-3apoA:
undetectable		 5jncA-3apoA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 8 THR A 275
CYH A 264
CYH A 270
TRP A 291
 None
 1.47A 5kxiA-3apoA:
undetectable
5kxiB-3apoA:
undetectable		 5kxiA-3apoA:
20.65
5kxiB-3apoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 8 THR A 275
CYH A 264
CYH A 270
TRP A 291
 None
 1.48A 5kxiD-3apoA:
undetectable
5kxiE-3apoA:
undetectable		 5kxiD-3apoA:
20.65
5kxiE-3apoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 7 PHE A 710
ARG A 766
LEU A 713
ALA A 723
 None
 1.24A 6b89A-3apoA:
undetectable		 6b89A-3apoA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3apo DNAJ HOMOLOG
SUBFAMILY C MEMBER
10
(Mus
musculus) 		4 / 8 HIS A 454
ARG A 366
HIS A 365
GLU A 394
 None
 1.19A 6mn4D-3apoA:
undetectable		 6mn4D-3apoA:
14.79