SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3apu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		5 / 11 SER A 114
TYR A  37
PHE A  51
LEU A  79
VAL A  88
 None
 1.19A 1q23I-3apuA:
undetectable		 1q23I-3apuA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		5 / 11 SER A 114
TYR A  37
PHE A  51
LEU A  79
VAL A  88
 None
 1.14A 1q23J-3apuA:
undetectable		 1q23J-3apuA:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		6 / 12 TYR A  37
GLU A  64
ARG A  90
HIS A  97
SER A  30
TYR A  27
 None
PG4  A 190 (-4.1A)
PG4  A 190 (-4.3A)
None
None
PG4  A 190 ( 3.8A)
 1.37A 3apvA-3apuA:
32.7		 3apvA-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		6 / 12 TYR A  37
PHE A  49
LEU A  62
HIS A  97
ALA A  99
SER A 114
 None
PG4  A 190 ( 4.1A)
None
None
PG4  A 190 ( 4.2A)
None
 1.48A 3apvA-3apuA:
32.7		 3apvA-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_A_TP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		12 / 12 TYR A  37
VAL A  41
PHE A  49
PHE A  51
LEU A  62
GLU A  64
ARG A  90
HIS A  97
ALA A  99
SER A 114
SER A 125
TYR A 127
 None
PG4  A 190 (-4.9A)
PG4  A 190 ( 4.1A)
None
None
PG4  A 190 (-4.1A)
PG4  A 190 (-4.3A)
None
PG4  A 190 ( 4.2A)
None
PG4  A 190 ( 3.7A)
None
 0.61A 3apvA-3apuA:
32.7		 3apvA-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		11 / 12 PHE A  32
TYR A  37
VAL A  41
PHE A  49
PHE A  51
LEU A  62
GLU A  64
ARG A  90
HIS A  97
ALA A  99
SER A 125
 None
None
PG4  A 190 (-4.9A)
PG4  A 190 ( 4.1A)
None
None
PG4  A 190 (-4.1A)
PG4  A 190 (-4.3A)
None
PG4  A 190 ( 4.2A)
PG4  A 190 ( 3.7A)
 0.71A 3apvB-3apuA:
32.5		 3apvB-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		11 / 12 PHE A  32
TYR A  37
VAL A  41
PHE A  49
PHE A  51
LEU A  62
GLU A  64
HIS A  97
ALA A  99
SER A 125
TYR A 127
 None
None
PG4  A 190 (-4.9A)
PG4  A 190 ( 4.1A)
None
None
PG4  A 190 (-4.1A)
None
PG4  A 190 ( 4.2A)
PG4  A 190 ( 3.7A)
None
 0.49A 3apvB-3apuA:
32.5		 3apvB-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APV_B_TP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		8 / 12 PHE A  32
TYR A  37
VAL A  41
PHE A  51
LEU A  79
HIS A  97
SER A 125
TYR A 127
 None
None
PG4  A 190 (-4.9A)
None
None
None
PG4  A 190 ( 3.7A)
None
 1.41A 3apvB-3apuA:
32.5		 3apvB-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		12 / 12 TYR A  27
PHE A  32
TYR A  37
VAL A  41
ILE A  44
PHE A  49
PHE A  51
GLU A  64
ALA A  99
SER A 114
SER A 125
TYR A 127
 PG4  A 190 ( 3.8A)
None
None
PG4  A 190 (-4.9A)
None
PG4  A 190 ( 4.1A)
None
PG4  A 190 (-4.1A)
PG4  A 190 ( 4.2A)
None
PG4  A 190 ( 3.7A)
None
 0.50A 3apwA-3apuA:
33.4		 3apwA-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APW_A_DP0A190_2
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		4 / 4 VAL A  88
ARG A  90
HIS A  97
PHE A 112
 None
PG4  A 190 (-4.3A)
None
PG4  A 190 ( 3.9A)
 0.28A 3apwA-3apuA:
33.4		 3apwA-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		12 / 12 VAL A  41
ILE A  44
PHE A  49
PHE A  51
LEU A  62
GLU A  64
GLN A  66
ARG A  90
ALA A  99
PHE A 112
SER A 125
TYR A 127
 PG4  A 190 (-4.9A)
None
PG4  A 190 ( 4.1A)
None
None
PG4  A 190 (-4.1A)
None
PG4  A 190 (-4.3A)
PG4  A 190 ( 4.2A)
PG4  A 190 ( 3.9A)
PG4  A 190 ( 3.7A)
None
 0.66A 3apwB-3apuA:
31.9		 3apwB-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		5 / 12 PHE A  32
PHE A  51
LEU A  62
PHE A 112
TYR A 127
 None
None
None
PG4  A 190 ( 3.9A)
None
 1.36A 3apxA-3apuA:
31.5		 3apxA-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		10 / 12 PHE A  32
VAL A  41
THR A  47
PHE A  49
PHE A  51
GLU A  64
LEU A  79
ALA A  99
PHE A 112
TYR A 127
 None
PG4  A 190 (-4.9A)
PG4  A 190 ( 4.6A)
PG4  A 190 ( 4.1A)
None
PG4  A 190 (-4.1A)
None
PG4  A 190 ( 4.2A)
PG4  A 190 ( 3.9A)
None
 0.56A 3apxA-3apuA:
31.5		 3apxA-3apuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		10 / 12 PHE A  32
VAL A  41
THR A  47
PHE A  49
PHE A  51
GLU A  64
LEU A  79
ARG A  90
GLU A  92
TYR A 127
 None
PG4  A 190 (-4.9A)
PG4  A 190 ( 4.6A)
PG4  A 190 ( 4.1A)
None
PG4  A 190 (-4.1A)
None
PG4  A 190 (-4.3A)
None
None
 0.91A 3apxA-3apuA:
31.5		 3apxA-3apuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3apu ALPHA-1-ACID
GLYCOPROTEIN 2
(Homo
sapiens) 		4 / 7 ARG A 152
GLN A   1
LEU A   8
ILE A   2
 None
 0.93A 3ln1C-3apuA:
undetectable		 3ln1C-3apuA:
14.63