SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 ILE B 273
ALA B 269
SER B 215
PRO B 217
ASN B 218
 None
 1.10A 1dlsA-3aq1B:
undetectable		 1dlsA-3aq1B:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 ALA B  88
ALA B 496
ALA B 493
VAL B 397
LEU B 127
 None
 1.34A 1rbpA-3aq1B:
undetectable		 1rbpA-3aq1B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 10 ASP B 138
ALA B 141
ILE B 484
ALA B 133
ILE B 134
 None
 1.00A 3ekwA-3aq1B:
undetectable		 3ekwA-3aq1B:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 4 LEU B 407
MET B 452
ILE B 484
ASP B 477
 None
 1.43A 3hecA-3aq1B:
undetectable		 3hecA-3aq1B:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 8 GLY B 467
GLN B 458
LEU B 468
ILE B 451
 None
 0.87A 3nbqB-3aq1B:
undetectable		 3nbqB-3aq1B:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 8 GLY B 467
GLN B 458
LEU B 468
ILE B 451
 None
 0.82A 3nbqC-3aq1B:
undetectable		 3nbqC-3aq1B:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 GLY B 400
GLY B 467
ASN B 481
VAL B 405
LEU B 440
 None
 1.10A 3p2kB-3aq1B:
undetectable		 3p2kB-3aq1B:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		3 / 3 LYS B 395
THR B 131
ILE B 126
 None
 0.86A 4e0fB-3aq1B:
undetectable		 4e0fB-3aq1B:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 GLU B 341
GLY B 347
VAL B 279
TYR B 300
VAL B 339
 None
 1.23A 4ffwA-3aq1B:
2.3		 4ffwA-3aq1B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 GLU B 341
GLY B 347
VAL B 279
TYR B 300
VAL B 339
 None
 1.24A 4ffwB-3aq1B:
undetectable		 4ffwB-3aq1B:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 11 GLN B 492
ALA B 493
ALA B 496
ALA B 497
THR B 501
 None
 0.77A 4j6cA-3aq1B:
undetectable		 4j6cA-3aq1B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 10 GLN B 492
ALA B 493
ALA B 496
ALA B 497
THR B 501
 None
 0.77A 4j6cB-3aq1B:
undetectable		 4j6cB-3aq1B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 GLN B 492
ALA B 493
ALA B 496
ALA B 497
THR B 501
 None
 0.87A 4jbtA-3aq1B:
undetectable		 4jbtA-3aq1B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 8 ASP B  83
VAL B 470
GLY B 400
ALA B 444
 None
 0.91A 4m48A-3aq1B:
2.1		 4m48A-3aq1B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 VAL B 339
VAL B 352
LEU B 313
THR B 317
ALA B 319
 None
 1.33A 4yhaA-3aq1B:
undetectable		 4yhaA-3aq1B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 8 PHE B 281
ALA B 301
LEU B 231
LEU B 230
 None
 1.15A 5dzkd-3aq1B:
2.1
5dzkr-3aq1B:
undetectable		 5dzkd-3aq1B:
18.84
5dzkr-3aq1B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 8 PHE B 281
ALA B 301
LEU B 231
LEU B 230
 None
 1.19A 5dzkF-3aq1B:
2.0
5dzkT-3aq1B:
undetectable		 5dzkF-3aq1B:
18.84
5dzkT-3aq1B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 6 GLY B 152
ASP B  83
ILE B 484
TYR B 471
 None
 1.11A 5iwuA-3aq1B:
undetectable		 5iwuA-3aq1B:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 VAL B 435
GLU B 434
LEU B  95
ALA B 432
LEU B 407
 None
 1.28A 5nd4B-3aq1B:
undetectable		 5nd4B-3aq1B:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 8 PHE B 281
LEU B 230
ASN B 278
VAL B 339
 None
 0.82A 5nujA-3aq1B:
undetectable		 5nujA-3aq1B:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 10 VAL B 339
VAL B 352
LEU B 313
THR B 317
ALA B 319
 None
 1.30A 5tt3A-3aq1B:
undetectable		 5tt3A-3aq1B:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 LEU B 229
ILE B 321
GLY B 334
GLY B 318
LEU B 231
 None
 1.01A 5twjA-3aq1B:
undetectable		 5twjA-3aq1B:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 10 LEU B 229
ILE B 321
GLY B 334
GLY B 318
LEU B 231
 None
 1.01A 5twjB-3aq1B:
undetectable		 5twjB-3aq1B:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 5 LEU B 127
LYS B 490
LEU B 407
GLU B 404
 None
 1.08A 5weaA-3aq1B:
2.0		 5weaA-3aq1B:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		5 / 12 LEU B 468
GLN B 458
GLY B 401
GLY B 399
GLY B 400
 None
 0.93A 5wyqB-3aq1B:
undetectable		 5wyqB-3aq1B:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 7 ALA B 119
ILE B 436
LEU B  91
ILE B 130
 None
 0.89A 6b5vA-3aq1B:
undetectable
6b5vB-3aq1B:
1.8		 6b5vA-3aq1B:
9.43
6b5vB-3aq1B:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3aq1 THERMOSOME SUBUNIT
(Methanococcoides
burtonii) 		4 / 6 VAL B 339
PRO B 220
ALA B 336
THR B 335
 None
 1.02A 6cduB-3aq1B:
undetectable
6cduC-3aq1B:
2.7		 6cduB-3aq1B:
21.24
6cduC-3aq1B:
21.24