SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.90A 1c6yB-3aqcB:
undetectable		 1c6yB-3aqcB:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.83A 1d4yA-3aqcB:
undetectable		 1d4yA-3aqcB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 PHE B  51
GLY B 200
ALA B 297
LEU B 301
 None
 0.79A 1e7bB-3aqcB:
2.3		 1e7bB-3aqcB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 4 THR B 237
LEU B 240
LEU B 247
GLN B 250
 None
 0.74A 1fbmA-3aqcB:
undetectable		 1fbmA-3aqcB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 5 THR B 237
LEU B 240
LEU B 247
GLN B 250
 None
 0.74A 1fbmE-3aqcB:
undetectable		 1fbmE-3aqcB:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 GLY B 200
CYH B 202
SER B 206
LEU B 321
TYR B 325
 None
 0.93A 1fm6D-3aqcB:
undetectable		 1fm6D-3aqcB:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ILE B 139
LEU B 181
HIS B  83
LEU B 120
ILE B 123
 None
None
2DE  B 329 ( 4.5A)
None
None
 1.24A 1fmlB-3aqcB:
undetectable		 1fmlB-3aqcB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 ILE B  87
LYS B 105
ALA B 108
VAL A  69
 None
 1.00A 1hk1A-3aqcB:
undetectable		 1hk1A-3aqcB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 SER A 107
VAL B  82
HIS B  83
LEU B 115
HIS B 113
 None
None
2DE  B 329 ( 4.5A)
None
None
 1.18A 1ie9A-3aqcA:
3.0		 1ie9A-3aqcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 GLY B 112
HIS B 113
ALA B  36
ALA B  35
ILE B  32
 None
 0.97A 1likA-3aqcB:
undetectable		 1likA-3aqcB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ALA B 243
ILE B 231
TYR B 216
ILE B 236
 None
 0.98A 1oniD-3aqcB:
undetectable
1oniF-3aqcB:
undetectable		 1oniD-3aqcB:
17.18
1oniF-3aqcB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 LEU B 255
THR B 217
TYR B 216
TYR B 273
 None
 1.32A 1qvuA-3aqcB:
undetectable		 1qvuA-3aqcB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.92A 1rqjA-3aqcB:
30.7		 1rqjA-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.81A 1rqjA-3aqcB:
30.7		 1rqjA-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.76A 1rqjA-3aqcB:
30.7		 1rqjA-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.91A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.79A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.75A 1rqjB-3aqcB:
30.8		 1rqjB-3aqcB:
28.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.87A 1sdvB-3aqcB:
undetectable		 1sdvB-3aqcB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 5 ALA B 286
TYR B 216
ILE B 213
ASP B 230
 None
None
None
MG  B 328 ( 3.6A)
 1.19A 1upfA-3aqcB:
undetectable		 1upfA-3aqcB:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 ASP B 212
GLU B 146
ARG B  48
 None
2DE  B 329 (-3.9A)
None
 0.77A 1wopA-3aqcB:
undetectable		 1wopA-3aqcB:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 PHE A  21
VAL A  74
LEU A  78
MET A  56
LEU A  11
 None
 1.26A 1wrkA-3aqcA:
undetectable
1wrkB-3aqcA:
undetectable		 1wrkA-3aqcA:
20.00
1wrkB-3aqcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 LEU A  11
PHE A  21
LEU A  78
MET A  56
 None
 0.84A 1wrlE-3aqcA:
undetectable
1wrlF-3aqcA:
undetectable		 1wrlE-3aqcA:
20.00
1wrlF-3aqcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.03A 1yhlA-3aqcB:
28.2		 1yhlA-3aqcB:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YHL_A_RISA1400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 1yhlA-3aqcB:
28.2		 1yhlA-3aqcB:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 11 ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.99A 1yq7A-3aqcB:
27.8		 1yq7A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.86A 1yq7A-3aqcB:
27.8		 1yq7A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.03A 1yv5A-3aqcB:
28.1		 1yv5A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 1yv5A-3aqcB:
28.1		 1yv5A-3aqcB:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.93A 1zw5A-3aqcB:
28.2		 1zw5A-3aqcB:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZW5_A_ZOLA901_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.96A 1zw5A-3aqcB:
28.2		 1zw5A-3aqcB:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.87A 2avvB-3aqcB:
undetectable		 2avvB-3aqcB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.88A 2b7zA-3aqcB:
undetectable		 2b7zA-3aqcB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ILE A 125
ASP A  58
SER A  76
ILE A  50
ILE A 102
 None
 1.26A 2blaA-3aqcA:
undetectable		 2blaA-3aqcA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
None
None
MG  B 328 (-3.1A)
 0.85A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.79A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_A_ZOLA901_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
THR B 171
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
MG  B 328 (-3.1A)
 0.91A 2e91A-3aqcB:
23.2		 2e91A-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E91_B_ZOLB902_1
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.06A 2e91B-3aqcB:
22.0		 2e91B-3aqcB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F89_F_210F9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.96A 2f89F-3aqcB:
28.7		 2f89F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.05A 2f8cF-3aqcB:
28.5		 2f8cF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8C_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 2f8cF-3aqcB:
28.5		 2f8cF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 2f8zF-3aqcB:
28.6		 2f8zF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.83A 2f8zF-3aqcB:
28.6		 2f8zF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.00A 2f94F-3aqcB:
28.3		 2f94F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.78A 2f94F-3aqcB:
28.3		 2f94F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.00A 2f9kF-3aqcB:
28.4		 2f9kF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9K_F_ZOLF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.81A 2f9kF-3aqcB:
28.4		 2f9kF-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.86A 2nmyA-3aqcB:
undetectable		 2nmyA-3aqcB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.81A 2nmzA-3aqcB:
undetectable		 2nmzA-3aqcB:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.92A 2nnkB-3aqcB:
undetectable		 2nnkB-3aqcB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.83A 2nnpA-3aqcB:
undetectable		 2nnpA-3aqcB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.67A 2o1oA-3aqcB:
26.2		 2o1oA-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 LEU B  81
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.95A 2o1oA-3aqcB:
26.2		 2o1oA-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 LEU B  81
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.99A 2o1oB-3aqcB:
26.9		 2o1oB-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.92A 2o1oB-3aqcB:
26.9		 2o1oB-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 12 LEU A  95
ASP A  27
VAL A  48
ILE A  31
VAL A  43
ILE A  47
 None
 1.35A 2o4lB-3aqcA:
undetectable		 2o4lB-3aqcA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.90A 2o4nA-3aqcB:
undetectable		 2o4nA-3aqcB:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.85A 2o4pA-3aqcB:
undetectable		 2o4pA-3aqcB:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 GLY B 228
ARG B 232
TYR B 216
 None
 0.88A 2opxA-3aqcB:
undetectable		 2opxA-3aqcB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 LEU B 115
VAL B  82
ILE B  39
ILE B  25
 None
 0.72A 2piwA-3aqcB:
undetectable		 2piwA-3aqcB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 1.05A 2q58A-3aqcB:
26.3		 2q58A-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 1.00A 2q58B-3aqcB:
26.7		 2q58B-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_B_ZOLB2_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 1.15A 2q58B-3aqcB:
26.7		 2q58B-3aqcB:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 12 LEU A  95
ASP A  27
VAL A  48
ILE A  31
VAL A  43
ILE A  47
 None
 1.48A 2q63A-3aqcA:
undetectable		 2q63A-3aqcA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
MG  B 328 (-3.1A)
 1.07A 2qisA-3aqcB:
28.4		 2qisA-3aqcB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.83A 2qisA-3aqcB:
28.4		 2qisA-3aqcB:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.85A 2r5pD-3aqcB:
undetectable		 2r5pD-3aqcB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.98A 2vcvB-3aqcB:
1.7		 2vcvB-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.99A 2vcvG-3aqcB:
undetectable		 2vcvG-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 LEU B 174
ALA B  79
LEU B 116
ALA B 119
 None
2DE  B 329 ( 4.4A)
2DE  B 329 ( 4.6A)
None
 0.97A 2vcvK-3aqcB:
undetectable		 2vcvK-3aqcB:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 PHE B  51
GLY B 204
PHE B 199
HIS B 317
ILE B 203
 None
 1.34A 2y7kA-3aqcB:
undetectable		 2y7kA-3aqcB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 PHE B  51
GLY B 204
PHE B 199
HIS B 317
ILE B 203
 None
 1.34A 2y7kC-3aqcB:
undetectable		 2y7kC-3aqcB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 GLY B 228
PHE B 154
TYR B 271
ARG B 232
 None
 1.38A 3ccfA-3aqcB:
undetectable		 3ccfA-3aqcB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.86A 3d1xA-3aqcB:
undetectable		 3d1xA-3aqcB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.84A 3d1yA-3aqcB:
undetectable		 3d1yA-3aqcB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.85A 3ekqA-3aqcB:
undetectable		 3ekqA-3aqcB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.82A 3el4A-3aqcB:
undetectable		 3el4A-3aqcB:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.82A 3ez3A-3aqcB:
28.6		 3ez3A-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.83A 3ez3A-3aqcB:
28.6		 3ez3A-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.95A 3ez3B-3aqcB:
28.3		 3ez3B-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 3ez3B-3aqcB:
28.3		 3ez3B-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.79A 3ez3B-3aqcB:
28.3		 3ez3B-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3ez3C-3aqcB:
28.7		 3ez3C-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.83A 3ez3C-3aqcB:
28.7		 3ez3C-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.82A 3ez3D-3aqcB:
28.0		 3ez3D-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EZ3_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 3ez3D-3aqcB:
28.0		 3ez3D-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 GLY B 200
CYH B 202
SER B 206
LEU B 321
TYR B 325
 None
 0.92A 3g9eA-3aqcB:
undetectable		 3g9eA-3aqcB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP A  73
SER A  76
ASP A  58
TYR B  86
 2DE  B 329 (-3.4A)
None
None
None
 1.21A 3havA-3aqcA:
2.6		 3havA-3aqcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IBA_A_ZOLA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.06A 3ibaA-3aqcB:
28.1		 3ibaA-3aqcB:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 12 LEU A  95
ASP A  27
VAL A  48
ILE A  31
VAL A  43
ILE A  47
 None
 1.37A 3jw2B-3aqcA:
undetectable		 3jw2B-3aqcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.85A 3ldwA-3aqcB:
28.6		 3ldwA-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3ldwA-3aqcB:
28.6		 3ldwA-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_A_ZOLA397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.87A 3ldwA-3aqcB:
28.6		 3ldwA-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3ldwB-3aqcB:
28.3		 3ldwB-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_B_ZOLB397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.79A 3ldwB-3aqcB:
28.3		 3ldwB-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.89A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.85A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_C_ZOLC397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
ARG B  93
LYS B 170
THR B 171
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
MG  B 328 (-3.1A)
 1.04A 3ldwC-3aqcB:
28.5		 3ldwC-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.81A 3ldwD-3aqcB:
28.1		 3ldwD-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LDW_D_ZOLD397_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.80A 3ldwD-3aqcB:
28.1		 3ldwD-3aqcB:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 LEU B  73
LEU B 116
THR B 138
ILE B 139
ALA B 119
 None
2DE  B 329 ( 4.6A)
None
None
None
 0.97A 3mdvB-3aqcB:
undetectable		 3mdvB-3aqcB:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_B_VIBB500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B 230
ASN B 233
TYR B 156
ILE B 231
GLY B 234
 MG  B 328 ( 3.6A)
None
None
None
None
 1.43A 3myuB-3aqcB:
0.0		 3myuB-3aqcB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 212
VAL B 278
ALA B 243
PHE B 160
THR B 237
 None
 1.29A 3n23A-3aqcB:
undetectable		 3n23A-3aqcB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 212
VAL B 278
ALA B 243
PHE B 160
THR B 237
 None
 1.29A 3n23C-3aqcB:
undetectable		 3n23C-3aqcB:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 11 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 3n45F-3aqcB:
28.5		 3n45F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N45_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 3n45F-3aqcB:
28.5		 3n45F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 3n46F-3aqcB:
28.4		 3n46F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N46_F_ZOLF354_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.80A 3n46F-3aqcB:
28.4		 3n46F-3aqcB:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.88A 3ndxA-3aqcB:
undetectable		 3ndxA-3aqcB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.84A 3ndxB-3aqcB:
undetectable		 3ndxB-3aqcB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ALA B 183
GLY B 182
HIS B 195
LEU B 304
TYR B 194
 None
 1.18A 3qxyA-3aqcB:
undetectable		 3qxyA-3aqcB:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.88A 3spkA-3aqcB:
undetectable		 3spkA-3aqcB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.82A 3spkB-3aqcB:
undetectable		 3spkB-3aqcB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASN A 103
ASP A  73
ILE B 109
HIS B  83
 None
2DE  B 329 (-3.4A)
None
2DE  B 329 ( 4.5A)
 1.04A 3t01A-3aqcA:
undetectable		 3t01A-3aqcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.87A 3tl9A-3aqcB:
undetectable		 3tl9A-3aqcB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus;
Micrococcus
luteus) 		5 / 12 PHE B 147
SER A  53
LEU B 116
VAL B  76
HIS B  83
 None
None
2DE  B 329 ( 4.6A)
2DE  B 329 ( 4.5A)
2DE  B 329 ( 4.5A)
 1.16A 3u9fH-3aqcB:
undetectable
3u9fI-3aqcB:
undetectable		 3u9fH-3aqcB:
19.38
3u9fI-3aqcB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ILE B 123
GLN A  89
LEU A  93
PHE A  92
VAL B  76
 None
None
None
None
2DE  B 329 ( 4.5A)
 1.22A 3uvvB-3aqcB:
undetectable		 3uvvB-3aqcB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 ASN B 308
LEU B 304
PHE B  57
 None
 0.81A 4dajB-3aqcB:
undetectable		 4dajB-3aqcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.18A 4feuB-3aqcB:
undetectable		 4feuB-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.15A 4feuF-3aqcB:
undetectable		 4feuF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.19A 4fevD-3aqcB:
undetectable		 4fevD-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.17A 4fevF-3aqcB:
undetectable		 4fevF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.15A 4fewD-3aqcB:
undetectable		 4fewD-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.14A 4fewF-3aqcB:
undetectable		 4fewF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.16A 4fexB-3aqcB:
undetectable		 4fexB-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.19A 4gkhB-3aqcB:
undetectable		 4gkhB-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.16A 4gkhF-3aqcB:
undetectable		 4gkhF-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.16A 4gkhG-3aqcB:
undetectable		 4gkhG-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.14A 4gkhC-3aqcB:
undetectable
4gkhK-3aqcB:
undetectable		 4gkhC-3aqcB:
21.10
4gkhK-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.15A 4gkiA-3aqcB:
undetectable		 4gkiA-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ASP B  88
ASP B 212
GLU B 146
ASP B 230
 MG  B 327 (-2.4A)
None
2DE  B 329 (-3.9A)
MG  B 328 ( 3.6A)
 1.14A 4gkiE-3aqcB:
undetectable
4gkiG-3aqcB:
undetectable		 4gkiE-3aqcB:
21.10
4gkiG-3aqcB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
LYS B 170
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
MG  B 328 (-3.1A)
 1.04A 4kfaA-3aqcB:
28.4		 4kfaA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFA_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.80A 4kfaA-3aqcB:
28.4		 4kfaA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.90A 4kpdA-3aqcB:
28.5		 4kpdA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.80A 4kpdA-3aqcB:
28.5		 4kpdA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.02A 4kpjA-3aqcB:
28.3		 4kpjA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 4kpjA-3aqcB:
28.3		 4kpjA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.97A 4kq5A-3aqcB:
28.2		 4kq5A-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQ5_A_ZOLA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 4kq5A-3aqcB:
28.2		 4kq5A-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4kqsA-3aqcB:
28.6		 4kqsA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 4kqsA-3aqcB:
28.6		 4kqsA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
ARG B  93
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
None
MG  B 328 (-3.1A)
 0.96A 4n9uA-3aqcB:
28.2		 4n9uA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N9U_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
None
 0.80A 4n9uA-3aqcB:
28.2		 4n9uA-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B  84
ASP B  88
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
None
None
MG  B 328 (-3.1A)
 0.89A 4ng6A-3aqcB:
28.2		 4ng6A-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
None
 0.74A 4ng6A-3aqcB:
28.2		 4ng6A-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.87A 4njuA-3aqcB:
undetectable		 4njuA-3aqcB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.89A 4njuC-3aqcB:
undetectable		 4njuC-3aqcB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  88
LYS B 170
THR B 171
GLN B 208
LYS B 225
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
2DE  B 329 ( 3.7A)
 1.36A 4nkeA-3aqcB:
28.2		 4nkeA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.85A 4nkeA-3aqcB:
28.2		 4nkeA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKE_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.04A 4nkeA-3aqcB:
28.2		 4nkeA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.07A 4nkfA-3aqcB:
28.4		 4nkfA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKF_A_210A404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.88A 4nkfA-3aqcB:
28.4		 4nkfA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.04A 4nuaA-3aqcB:
28.3		 4nuaA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
LYS B 225
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
2DE  B 329 ( 3.7A)
 1.29A 4nuaA-3aqcB:
28.3		 4nuaA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 4nuaA-3aqcB:
28.3		 4nuaA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.83A 4oguA-3aqcB:
28.2		 4oguA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGU_A_210A405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 LEU B  81
ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 4oguA-3aqcB:
28.2		 4oguA-3aqcB:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.90A 4p0vA-3aqcB:
28.5		 4p0vA-3aqcB:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0V_A_ZOLA401_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.95A 4p0vA-3aqcB:
28.5		 4p0vA-3aqcB:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P0W_A_ZOLA501_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 11 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.84A 4p0wA-3aqcB:
28.4		 4p0wA-3aqcB:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 LEU B  75
THR A  96
ALA B 117
LEU B 115
 None
 0.93A 4pwjA-3aqcB:
undetectable		 4pwjA-3aqcB:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.94A 4q1xA-3aqcB:
undetectable		 4q1xA-3aqcB:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q23_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.88A 4q23A-3aqcB:
28.1		 4q23A-3aqcB:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 TYR B 156
GLY B 234
ASP B 215
GLY B 228
TYR B 216
 None
 1.13A 4qa0A-3aqcB:
undetectable		 4qa0A-3aqcB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 TYR B 156
GLY B 234
ASP B 215
GLY B 228
TYR B 216
 None
 1.13A 4qa2A-3aqcB:
undetectable		 4qa2A-3aqcB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 TYR B 156
GLY B 234
ASP B 215
GLY B 228
TYR B 216
 None
 1.17A 4qa2B-3aqcB:
undetectable		 4qa2B-3aqcB:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_A_RISA1404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		8 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4rxdA-3aqcB:
27.7		 4rxdA-3aqcB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_B_RISB1504_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		8 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4rxdB-3aqcB:
28.0		 4rxdB-3aqcB:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RXD_C_RISC1600_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		8 / 10 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.01A 4rxdC-3aqcB:
28.2		 4rxdC-3aqcB:
23.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 8 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.94A 4umjA-3aqcB:
28.4		 4umjA-3aqcB:
32.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 9 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.82A 4umjB-3aqcB:
28.8		 4umjB-3aqcB:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 GLY B 200
CYH B 202
SER B 206
LEU B 321
TYR B 325
 None
 0.95A 4xldA-3aqcB:
undetectable		 4xldA-3aqcB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 8 ILE A  31
LEU A  75
LEU A  78
ILE A   7
 None
 0.92A 4xtaB-3aqcA:
undetectable		 4xtaB-3aqcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 6 HIS B  77
GLY B  44
GLU B  74
ARG B  46
 None
 1.28A 4zbqA-3aqcB:
2.6		 4zbqA-3aqcB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 4 ILE B  25
ARG B  46
TYR B  22
GLU B  18
 None
 1.47A 4zzbD-3aqcB:
undetectable		 4zzbD-3aqcB:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 ARG B  46
TYR B  22
GLU B  18
 None
 0.67A 4zzbE-3aqcB:
undetectable		 4zzbE-3aqcB:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 1.02A 5cg5A-3aqcB:
28.0		 5cg5A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG5_A_RISA400_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.83A 5cg5A-3aqcB:
28.0		 5cg5A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		6 / 12 ASP B  84
ASP B  88
LYS B 170
THR B 171
GLN B 208
ASP B 211
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
None
None
MG  B 328 (-3.1A)
 0.98A 5cg6A-3aqcB:
28.6		 5cg6A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CG6_A_RISA404_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		7 / 12 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
None
 0.82A 5cg6A-3aqcB:
28.6		 5cg6A-3aqcB:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_A_210A804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 1.10A 5eroA-3aqcB:
27.4		 5eroA-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_B_210B804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B  84
ASP B  88
ARG B  93
LYS B 170
ASP B 230
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
MG  B 328 ( 3.6A)
 1.49A 5eroB-3aqcB:
27.2		 5eroB-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  84
ASP B  85
ASP B  88
ARG B  93
ASP B 230
 MG  B 326 (-2.6A)
MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
MG  B 328 ( 3.6A)
 1.09A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  84
ASP B  85
ASP B  88
LYS B 170
ASP B 230
 MG  B 326 (-2.6A)
MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-2.5A)
MG  B 328 ( 3.6A)
 1.39A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERO_C_210C804_1
(FUSICOCCADIENE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 10 ASP B  85
ASP B  88
ARG B  93
GLN B 208
ASP B 211
 MG  B 326 ( 4.8A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
MG  B 328 (-3.1A)
 1.02A 5eroC-3aqcB:
27.0		 5eroC-3aqcB:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 PHE A  59
ILE A  24
ASP A  73
PHE A  68
 None
None
2DE  B 329 (-3.4A)
None
 0.86A 5h3aA-3aqcA:
undetectable		 5h3aA-3aqcA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 ALA B 243
ASN B 246
LEU B 247
 None
 0.48A 5i1nC-3aqcB:
undetectable		 5i1nC-3aqcB:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 11 ILE B 123
GLN A  89
LEU A  93
PHE A  92
VAL B  76
 None
None
None
None
2DE  B 329 ( 4.5A)
 1.24A 5ji0A-3aqcB:
undetectable		 5ji0A-3aqcB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.86A 5kqxA-3aqcB:
undetectable		 5kqxA-3aqcB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.91A 5kr2A-3aqcB:
undetectable		 5kr2A-3aqcB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 9 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.88A 5kr2C-3aqcB:
undetectable		 5kr2C-3aqcB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ILE B 123
LEU B  66
ILE B 134
SER B 185
THR B 138
 None
 1.19A 5tiwB-3aqcB:
undetectable		 5tiwB-3aqcB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ILE B 123
LEU B  66
PHE B 131
SER B 185
THR B 138
 None
 1.27A 5tiwB-3aqcB:
undetectable		 5tiwB-3aqcB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 PHE A  20
ASP B 148
LEU A  78
 None
 0.71A 5uhbC-3aqcA:
undetectable		 5uhbC-3aqcA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3aqc COMPONENT A OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		3 / 3 PHE A  20
ASP B 148
LEU A  78
 None
 0.75A 5uhcC-3aqcA:
undetectable		 5uhcC-3aqcA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 12 ASP B 211
ASP B 212
ILE B 167
GLY B 204
ILE B 203
 MG  B 328 (-3.1A)
None
None
None
None
 0.85A 6dilA-3aqcB:
undetectable		 6dilA-3aqcB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ARG B  93
LYS B 170
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 1.28A 6g31A-3aqcB:
26.6		 6g31A-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ASP B  88
ARG B  93
LYS B 170
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.94A 6g31A-3aqcB:
26.6		 6g31A-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_C_ZOLC401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 5 ASP B  84
ASP B  88
ARG B  93
LYS B 170
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 1.00A 6g31C-3aqcB:
26.4		 6g31C-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		5 / 7 LEU B  81
ASP B  84
ASP B  88
ARG B  93
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
 0.77A 6g31D-3aqcB:
26.2		 6g31D-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_E_ZOLE401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 4 LEU B  81
ASP B  84
ASP B  88
ARG B  93
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
 0.46A 6g31E-3aqcB:
20.6		 6g31E-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ARG B  93
LYS B 170
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.98A 6g31G-3aqcB:
25.8		 6g31G-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE
(Micrococcus
luteus) 		4 / 7 ASP B  84
ASP B  88
ARG B  93
LYS B 170
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.95A 6g31G-3aqcB:
25.8		 6g31G-3aqcB:
13.62