SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 148
GLY A 132
VAL A  89
MET A 135
LEU A  77
 None
 1.35A 1mx1E-3aqgA:
undetectable		 1mx1E-3aqgA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 LEU A 113
MET A 133
PHE A 145
SER A  88
ILE A  74
 None
 1.40A 1xosA-3aqgA:
undetectable		 1xosA-3aqgA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 GLY A 180
ILE A  74
LEU A  77
VAL A  79
MET A 135
 None
 0.98A 3adxB-3aqgA:
undetectable		 3adxB-3aqgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 PHE A 129
ILE A 176
GLY A 175
VAL A  86
LEU A 173
 None
 1.02A 3fpjA-3aqgA:
undetectable		 3fpjA-3aqgA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 ILE A 179
GLN A 127
LEU A 130
VAL A  86
TYR A 144
 None
 1.14A 4g1bD-3aqgA:
undetectable		 4g1bD-3aqgA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		4 / 6 ARG A  78
GLY A  76
THR A 112
GLU A 110
 PO4  A   2 (-3.3A)
None
None
PO4  A   2 (-3.3A)
 1.11A 5ny7A-3aqgA:
undetectable		 5ny7A-3aqgA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 GLY A 102
VAL A 122
LEU A 164
GLY A 180
ILE A 179
 None
 0.95A 5vooA-3aqgA:
undetectable		 5vooA-3aqgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 GLY A 102
VAL A 122
LEU A 164
GLY A 180
ILE A 179
 None
 0.95A 5vooC-3aqgA:
undetectable		 5vooC-3aqgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 GLY A 102
VAL A 122
LEU A 164
GLY A 180
ILE A 179
 None
 1.01A 5vooE-3aqgA:
undetectable		 5vooE-3aqgA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3aqg ZYMOGEN GRANULE
PROTEIN 16 HOMOLOG B
(Homo
sapiens) 		5 / 12 GLY A 102
VAL A 122
LEU A 164
GLY A 180
ILE A 179
 None
 0.93A 5vopA-3aqgA:
undetectable		 5vopA-3aqgA:
17.94