SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		5 / 10 GLY A 413
LEU A 408
PHE A 386
TRP A 412
LEU A 393
 None
 1.17A 1a8uA-3aqkA:
undetectable		 1a8uA-3aqkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		5 / 10 GLY A 413
LEU A 408
PHE A 386
TRP A 412
LEU A 393
 None
 1.22A 1a8uB-3aqkA:
undetectable		 1a8uB-3aqkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		4 / 8 PHE A 236
ILE A 351
PHE A 265
LEU A 240
 None
 0.74A 1fslA-3aqkA:
1.5		 1fslA-3aqkA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		4 / 8 PHE A 236
ILE A 351
PHE A 265
LEU A 240
 None
 0.66A 1fslB-3aqkA:
1.7		 1fslB-3aqkA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		4 / 6 ALA A 201
TYR A 191
ILE A 212
ILE A 220
 None
 1.08A 2dcfA-3aqkA:
undetectable		 2dcfA-3aqkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		3 / 3 PHE A 152
ASN A 155
PHE A 204
 None
 1.09A 2zbuD-3aqkA:
undetectable		 2zbuD-3aqkA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		4 / 7 ALA A 201
TYR A 191
ILE A 212
ILE A 220
 None
 1.09A 2zm7A-3aqkA:
undetectable		 2zm7A-3aqkA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		4 / 8 ILE A 220
PRO A 219
SER A 213
PRO A 187
 None
 0.96A 3lslA-3aqkA:
undetectable
3lslD-3aqkA:
undetectable		 3lslA-3aqkA:
21.00
3lslD-3aqkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		4 / 8 PRO A 187
ILE A 220
PRO A 219
SER A 213
 None
 0.96A 3lslA-3aqkA:
undetectable
3lslD-3aqkA:
undetectable		 3lslA-3aqkA:
21.00
3lslD-3aqkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		3 / 3 ARG A 149
VAL A  54
THR A  73
 None
 0.82A 3ndtA-3aqkA:
undetectable		 3ndtA-3aqkA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		3 / 3 LEU A 405
LEU A 408
TRP A 411
 None
 0.74A 5nwuA-3aqkA:
undetectable		 5nwuA-3aqkA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		3 / 3 LEU A 430
LEU A 427
TRP A 378
 None
 0.94A 5nwuA-3aqkA:
undetectable		 5nwuA-3aqkA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		4 / 6 PHE A 305
ARG A 294
ARG A 300
ALA A 308
 None
 1.07A 6b89B-3aqkA:
undetectable		 6b89B-3aqkA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		5 / 11 ILE A 220
PRO A 219
SER A 213
PRO A 187
ASP A 175
 None
 1.17A 6dlzA-3aqkA:
undetectable
6dlzD-3aqkA:
undetectable		 6dlzA-3aqkA:
9.68
6dlzD-3aqkA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		5 / 11 ILE A 220
PRO A 219
SER A 213
PRO A 187
ASP A 175
 None
 1.17A 6dm1A-3aqkA:
undetectable
6dm1D-3aqkA:
undetectable		 6dm1A-3aqkA:
9.68
6dm1D-3aqkA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3aqk POLY(A) POLYMERASE
(Escherichia
coli) 		3 / 3 LEU A 242
ASN A 155
LEU A 208
 None
 0.72A 6exiD-3aqkA:
undetectable		 6exiD-3aqkA:
14.67