SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 168
LEU A 182
LEU A 232
GLU A 237
GLU A 236
 None
 1.40A 1a29A-3aqoA:
undetectable		 1a29A-3aqoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 108
LEU A 250
GLY A 248
ALA A 242
ASP A 209
 None
 1.03A 2bm9F-3aqoA:
undetectable		 2bm9F-3aqoA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 ALA A 221
THR A 196
GLY A 225
PHE A 184
GLY A 188
 None
 0.93A 4rzvA-3aqoA:
undetectable		 4rzvA-3aqoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 PRO A 216
GLU A 240
ALA A 168
LEU A 165
 None
 1.08A 5igiA-3aqoA:
undetectable		 5igiA-3aqoA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A 156
VAL A 212
ILE A 206
VAL A 207
 None
 0.78A 5ik1A-3aqoA:
undetectable		 5ik1A-3aqoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A 113
ARG A 116
ILE A 206
PHE A 115
 None
 0.94A 5kirB-3aqoA:
undetectable		 5kirB-3aqoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3aqo PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 TYR A 213
ILE A 229
ALA A 238
VAL A 235
 None
 1.05A 6hu9a-3aqoA:
undetectable
6hu9e-3aqoA:
undetectable		 6hu9a-3aqoA:
19.84
6hu9e-3aqoA:
25.13