SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 SER A 634
VAL A 601
GLY A 704
GLY A 708
 None
 0.67A 1aq7A-3aqpA:
undetectable		 1aq7A-3aqpA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.65A 1dvxB-3aqpA:
undetectable		 1dvxB-3aqpA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A  92
PRO A  93
LEU A  95
ARG A 102
 None
 1.33A 1hrkB-3aqpA:
undetectable		 1hrkB-3aqpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 695
THR A 513
VAL A 515
 None
 1.00A 1hxbA-3aqpA:
undetectable		 1hxbA-3aqpA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.80A 1hxwB-3aqpA:
undetectable		 1hxwB-3aqpA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.86A 1muiB-3aqpA:
undetectable		 1muiB-3aqpA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 GLY A 429
ILE A 431
ALA A 362
ILE A 363
 None
 0.75A 1n49A-3aqpA:
undetectable		 1n49A-3aqpA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.83A 1ohrA-3aqpA:
undetectable		 1ohrA-3aqpA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 5 SER A 638
SER A 642
VAL A 585
PHE A 589
 None
 0.86A 1oipA-3aqpA:
undetectable		 1oipA-3aqpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.81A 1t3rA-3aqpA:
undetectable		 1t3rA-3aqpA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 SER A 634
VAL A 601
GLY A 704
GLY A 708
 None
 0.72A 1tnlA-3aqpA:
undetectable		 1tnlA-3aqpA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.89A 1tt6B-3aqpA:
undetectable		 1tt6B-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.98A 1tz8C-3aqpA:
undetectable
1tz8D-3aqpA:
undetectable		 1tz8C-3aqpA:
9.85
1tz8D-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 ALA A 586
TYR A 584
ILE A 635
ASP A 376
 None
 0.80A 1upfB-3aqpA:
undetectable		 1upfB-3aqpA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 421
LEU A 425
LEU A 297
LEU A 299
 None
 1.05A 2ab2B-3aqpA:
undetectable		 2ab2B-3aqpA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.82A 2aquA-3aqpA:
undetectable		 2aquA-3aqpA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.83A 2aquB-3aqpA:
undetectable		 2aquB-3aqpA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.89A 2f81B-3aqpA:
undetectable		 2f81B-3aqpA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.87A 2fxeB-3aqpA:
undetectable		 2fxeB-3aqpA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A  92
PRO A  93
LEU A  95
ARG A 102
 None
 1.34A 2hrcB-3aqpA:
undetectable		 2hrcB-3aqpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.91A 2ienA-3aqpA:
undetectable		 2ienA-3aqpA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.96A 2ieoA-3aqpA:
undetectable		 2ieoA-3aqpA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		3 / 3 ALA A 554
GLY A 267
SER A 692
 None
 0.50A 2ivuA-3aqpA:
2.0		 2ivuA-3aqpA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 SER A 597
SER A 712
VAL A 716
SER A 634
 None
 1.44A 2j9cA-3aqpA:
4.0
2j9cB-3aqpA:
4.0
2j9cC-3aqpA:
3.1		 2j9cA-3aqpA:
10.66
2j9cB-3aqpA:
10.66
2j9cC-3aqpA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.89A 2nnpA-3aqpA:
undetectable		 2nnpA-3aqpA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.85A 2o4kB-3aqpA:
undetectable		 2o4kB-3aqpA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 SER A 634
VAL A 601
GLY A 704
GLY A 708
 None
 0.72A 2otvA-3aqpA:
undetectable		 2otvA-3aqpA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 4 SER A 413
GLY A 304
HIS A 381
ASP A 637
 None
 1.40A 2oxtC-3aqpA:
undetectable		 2oxtC-3aqpA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 4 LEU A  92
PRO A  93
LEU A  95
ARG A 102
 None
 1.40A 2pnjB-3aqpA:
undetectable		 2pnjB-3aqpA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.88A 2q5kB-3aqpA:
undetectable		 2q5kB-3aqpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.77A 2q63A-3aqpA:
undetectable		 2q63A-3aqpA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.76A 2q64B-3aqpA:
undetectable		 2q64B-3aqpA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 695
THR A 513
VAL A 515
 None
 0.97A 2qakA-3aqpA:
undetectable		 2qakA-3aqpA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.75A 2r5qB-3aqpA:
undetectable		 2r5qB-3aqpA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 SER A 634
LEU A 582
LEU A 578
ILE A 635
ALA A 380
 None
 1.18A 2v0mC-3aqpA:
undetectable		 2v0mC-3aqpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A 388
LEU A 333
ALA A 329
PHE A 697
 None
 0.92A 2vcvG-3aqpA:
1.9		 2vcvG-3aqpA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 ALA A 409
SER A 413
GLY A 304
ALA A 338
 None
 0.79A 2vh3B-3aqpA:
1.1		 2vh3B-3aqpA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 SER A 634
VAL A 601
GLY A 704
GLY A 708
 None
 0.72A 2vinA-3aqpA:
undetectable		 2vinA-3aqpA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 5 VAL A 640
VAL A 343
ASP A 340
SER A 676
 None
 1.34A 2x45A-3aqpA:
undetectable		 2x45A-3aqpA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.79A 2z54B-3aqpA:
undetectable		 2z54B-3aqpA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 GLY A 690
GLY A 274
ALA A 273
GLU A 524
 None
 0.64A 3aruA-3aqpA:
undetectable		 3aruA-3aqpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 663
VAL A 641
THR A 668
 None
 0.80A 3cyxA-3aqpA:
undetectable		 3cyxA-3aqpA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.98A 3d2tA-3aqpA:
undetectable		 3d2tA-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.75A 3d2tA-3aqpA:
undetectable		 3d2tA-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.76A 3ekyA-3aqpA:
undetectable		 3ekyA-3aqpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.84A 3el1B-3aqpA:
undetectable		 3el1B-3aqpA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 5 ASN A 342
ASN A 378
HIS A 381
ALA A 337
 None
 1.40A 3frqA-3aqpA:
undetectable		 3frqA-3aqpA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 ASN A 342
ASN A 378
HIS A 381
ALA A 337
 None
 1.41A 3frqB-3aqpA:
undetectable		 3frqB-3aqpA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 SER A 711
LEU A 680
SER A 676
SER A 634
GLY A 704
 None
 1.39A 3ijxB-3aqpA:
undetectable
3ijxD-3aqpA:
undetectable		 3ijxB-3aqpA:
16.42
3ijxD-3aqpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 ILE A 285
PRO A 682
SER A 277
GLY A 281
LEU A 305
 None
 1.21A 3ik6B-3aqpA:
undetectable
3ik6E-3aqpA:
undetectable		 3ik6B-3aqpA:
16.42
3ik6E-3aqpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 SER A 634
GLY A 704
SER A 711
LEU A 680
SER A 676
 None
 1.30A 3ik6B-3aqpA:
undetectable
3ik6E-3aqpA:
undetectable		 3ik6B-3aqpA:
16.42
3ik6E-3aqpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 SER A 711
LEU A 680
SER A 676
SER A 634
GLY A 704
 None
 1.36A 3ik6B-3aqpA:
undetectable
3ik6E-3aqpA:
undetectable		 3ik6B-3aqpA:
16.42
3ik6E-3aqpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.85A 3k4vA-3aqpA:
undetectable		 3k4vA-3aqpA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 9 PHE A 589
VAL A 585
GLN A 649
VAL A 716
GLY A 594
 None
 1.07A 3km6B-3aqpA:
undetectable		 3km6B-3aqpA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		3 / 3 SER A 711
GLY A 708
SER A 638
 None
 0.48A 3loqA-3aqpA:
undetectable		 3loqA-3aqpA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.92A 3lzsA-3aqpA:
undetectable		 3lzsA-3aqpA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.91A 3lzsB-3aqpA:
undetectable		 3lzsB-3aqpA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.89A 3lzuA-3aqpA:
undetectable		 3lzuA-3aqpA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.74A 3lzvA-3aqpA:
undetectable		 3lzvA-3aqpA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 PRO A 531
GLY A 480
GLY A 479
ASP A 534
LEU A  43
 None
 1.01A 3m6vA-3aqpA:
undetectable		 3m6vA-3aqpA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 PRO A 531
GLY A 480
GLY A 479
ASP A 534
LEU A  43
 None
 0.97A 3m6vB-3aqpA:
undetectable		 3m6vB-3aqpA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 PRO A 531
GLY A 480
GLY A 479
ASP A 534
LEU A  43
 None
 0.99A 3m6wA-3aqpA:
undetectable		 3m6wA-3aqpA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 VAL A 585
PHE A 589
ILE A 635
THR A 672
VAL A 716
 None
 1.00A 3me6A-3aqpA:
undetectable		 3me6A-3aqpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 9 VAL A 585
PHE A 589
ILE A 635
THR A 672
VAL A 716
 None
 1.04A 3me6C-3aqpA:
undetectable		 3me6C-3aqpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 9 VAL A 585
PHE A 589
ILE A 635
THR A 672
VAL A 716
 None
 1.08A 3me6D-3aqpA:
1.0		 3me6D-3aqpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.81A 3ndxB-3aqpA:
undetectable		 3ndxB-3aqpA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.82A 3nu9B-3aqpA:
undetectable		 3nu9B-3aqpA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 9 GLY A 281
ILE A 683
GLY A 274
ILE A 275
LEU A 335
 None
 1.02A 3ogpB-3aqpA:
undetectable		 3ogpB-3aqpA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.76A 3oy4B-3aqpA:
undetectable		 3oy4B-3aqpA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 SER A 634
VAL A 601
GLY A 704
GLY A 708
 None
 0.73A 3rxfA-3aqpA:
undetectable		 3rxfA-3aqpA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.83A 3tl9A-3aqpA:
undetectable		 3tl9A-3aqpA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.89A 3tl9B-3aqpA:
undetectable		 3tl9B-3aqpA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 9 LEU A 540
LEU A 529
ILE A 262
GLU A 556
PHE A 544
 None
 1.31A 3tmzA-3aqpA:
undetectable		 3tmzA-3aqpA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.79A 3ucbA-3aqpA:
undetectable		 3ucbA-3aqpA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.80A 3ucbB-3aqpA:
undetectable		 3ucbB-3aqpA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 SER A 638
SER A 642
ILE A 598
VAL A 585
PHE A 589
 None
 1.10A 3w67A-3aqpA:
undetectable		 3w67A-3aqpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 SER A 638
SER A 642
ILE A 598
VAL A 585
PHE A 589
 None
 1.20A 3w68A-3aqpA:
undetectable		 3w68A-3aqpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 ARG A 135
ARG A 142
TYR A 213
GLU A  67
 None
 1.25A 3zmdA-3aqpA:
0.9
3zmdB-3aqpA:
undetectable		 3zmdA-3aqpA:
12.89
3zmdB-3aqpA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 ARG A 135
LEU A 134
ARG A 142
GLU A  67
 None
 1.27A 3zmdA-3aqpA:
0.9
3zmdB-3aqpA:
undetectable		 3zmdA-3aqpA:
12.89
3zmdB-3aqpA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.80A 4dqbB-3aqpA:
undetectable		 4dqbB-3aqpA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.86A 4dqeB-3aqpA:
undetectable		 4dqeB-3aqpA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.81A 4dqfB-3aqpA:
undetectable		 4dqfB-3aqpA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.80A 4dqhB-3aqpA:
undetectable		 4dqhB-3aqpA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 266
ILE A 262
ALA A 482
ALA A 554
THR A 484
 None
 1.16A 4enhA-3aqpA:
undetectable		 4enhA-3aqpA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.98A 4i89A-3aqpA:
undetectable		 4i89A-3aqpA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 382
ALA A 625
PHE A 399
LEU A 315
THR A 334
 None
 1.35A 4iaqA-3aqpA:
undetectable		 4iaqA-3aqpA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.81A 4iizB-3aqpA:
undetectable		 4iizB-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 4 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.74A 4ik6A-3aqpA:
undetectable		 4ik6A-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.77A 4ik6B-3aqpA:
undetectable		 4ik6B-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 7 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.67A 4ik7A-3aqpA:
undetectable		 4ik7A-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 LEU A 335
LEU A 331
GLY A 330
VAL A 407
THR A 679
 None
 1.34A 4oktA-3aqpA:
undetectable		 4oktA-3aqpA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 ASN A 342
PHE A 346
GLY A 298
SER A 302
SER A 413
 None
 1.38A 4ot2A-3aqpA:
3.5		 4ot2A-3aqpA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_A_30ZA201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.94A 4pwjA-3aqpA:
undetectable		 4pwjA-3aqpA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 9 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.77A 4q1wA-3aqpA:
undetectable		 4q1wA-3aqpA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.78A 4q1xA-3aqpA:
undetectable		 4q1xA-3aqpA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.77A 4q1yA-3aqpA:
undetectable		 4q1yA-3aqpA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.86A 4qgiA-3aqpA:
undetectable		 4qgiA-3aqpA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 ALA A 596
SER A 638
SER A 634
ALA A 602
 None
 0.77A 4twdF-3aqpA:
1.4
4twdG-3aqpA:
0.6
4twdH-3aqpA:
0.7
4twdI-3aqpA:
1.7
4twdJ-3aqpA:
undetectable		 4twdF-3aqpA:
19.92
4twdG-3aqpA:
19.92
4twdH-3aqpA:
19.92
4twdI-3aqpA:
19.92
4twdJ-3aqpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 708
LEU A 333
LEU A 403
ALA A 384
HIS A 381
 None
 1.04A 4wcxC-3aqpA:
undetectable		 4wcxC-3aqpA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		3 / 3 ASP A 269
LEU A 689
GLY A 690
 None
 0.56A 4xmfA-3aqpA:
undetectable		 4xmfA-3aqpA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 11 PHE A 471
ALA A 606
VAL A 605
VAL A 466
GLY A 610
 None
 1.09A 4xnxA-3aqpA:
undetectable		 4xnxA-3aqpA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 ASN A 342
PHE A 346
GLY A 298
SER A 302
SER A 413
 None
 1.36A 4zbrA-3aqpA:
undetectable		 4zbrA-3aqpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 625
LEU A 388
ALA A 392
LEU A 403
ALA A 400
 None
 1.02A 4zbrA-3aqpA:
undetectable		 4zbrA-3aqpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 LYS A 528
LEU A 526
ALA A 482
VAL A 558
 None
 0.71A 5a6iA-3aqpA:
undetectable		 5a6iA-3aqpA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.97A 5bojA-3aqpA:
undetectable		 5bojA-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 267
GLY A 263
THR A 484
ILE A 271
LEU A  39
 None
 1.17A 5bw4A-3aqpA:
undetectable		 5bw4A-3aqpA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 5 LEU A 208
ALA A 111
LEU A 113
VAL A 252
 None
 1.12A 5cr1A-3aqpA:
undetectable		 5cr1A-3aqpA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		3 / 3 ARG A 644
HIS A 369
ARG A 348
 None
 1.18A 5iaoF-3aqpA:
undetectable		 5iaoF-3aqpA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  92
ALA A 261
LEU A  95
SER A  96
 None
 0.94A 5l4iA-3aqpA:
undetectable		 5l4iA-3aqpA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A 204
PHE A 115
ALA A 227
PHE A 184
 None
 1.00A 5m0oC-3aqpA:
undetectable		 5m0oC-3aqpA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 ALA A 329
LEU A 331
VAL A 332
LEU A 323
ILE A 271
 None
 1.12A 5v02B-3aqpA:
2.1
5v02R-3aqpA:
undetectable		 5v02B-3aqpA:
8.91
5v02R-3aqpA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		4 / 5 PRO A 531
GLY A 480
THR A 481
LYS A 528
 None
 1.17A 5x23A-3aqpA:
undetectable		 5x23A-3aqpA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.73A 6dgxA-3aqpA:
undetectable		 6dgxA-3aqpA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.76A 6dh0A-3aqpA:
undetectable		 6dh0A-3aqpA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 GLY A 327
ALA A 329
GLY A 274
ILE A 271
VAL A 693
 None
 0.86A 6dilB-3aqpA:
undetectable		 6dilB-3aqpA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 675
SER A 345
SER A 370
ASN A 414
ASN A 378
 None
 1.45A 6h7jA-3aqpA:
2.2		 6h7jA-3aqpA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_B_5FWB402_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 675
SER A 345
SER A 370
ASN A 414
ASN A 378
 None
 1.45A 6h7jB-3aqpA:
undetectable		 6h7jB-3aqpA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_A_68HA504_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 12 THR A 675
SER A 345
SER A 370
ASN A 414
ASN A 378
 None
 1.44A 6h7mA-3aqpA:
2.2		 6h7mA-3aqpA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN
(Thermus
thermophilus) 		5 / 10 GLY A  41
ALA A 554
LEU A 266
GLY A 267
LEU A 615
 None
 1.38A 6hqbA-3aqpA:
undetectable
6hqbJ-3aqpA:
undetectable		 6hqbA-3aqpA:
7.15
6hqbJ-3aqpA:
4.45