SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ask'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		3 / 3 CYH A 313
ARG A 324
CYH A 305
 ZN  A 501 (-2.3A)
ZN  A 501 (-4.4A)
ZN  A 501 (-2.3A)
 1.41A 1p9gA-3askA:
undetectable		 1p9gA-3askA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		3 / 3 GLY A 323
CYH A 321
CYH A 318
 None
ZN  A 502 (-2.3A)
ZN  A 502 (-2.3A)
 0.75A 5inzB-3askA:
undetectable		 5inzB-3askA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 8 GLU A 234
GLY A 299
PRO A 300
ASP A 307
 None
 1.14A 5kf8A-3askA:
undetectable		 5kf8A-3askA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 4 VAL A 156
VAL A 186
TYR A 184
GLN A 198
 None
 1.06A 5qggA-3askA:
undetectable		 5qggA-3askA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGO_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 4 VAL A 156
VAL A 186
TYR A 184
GLN A 198
 None
 1.04A 5qgoA-3askA:
undetectable		 5qgoA-3askA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGP_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 4 VAL A 156
VAL A 186
TYR A 184
GLN A 198
 None
 1.04A 5qgpA-3askA:
undetectable		 5qgpA-3askA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGQ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 4 VAL A 156
VAL A 186
TYR A 184
GLN A 198
 None
 1.03A 5qgqA-3askA:
undetectable		 5qgqA-3askA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHB_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3ask E3 UBIQUITIN-PROTEIN
LIGASE UHRF1
(Homo
sapiens) 		4 / 4 VAL A 156
VAL A 186
TYR A 184
GLN A 198
 None
 1.05A 5qhbA-3askA:
undetectable		 5qhbA-3askA:
20.68