SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3asu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		5 / 12 THR A 114
VAL A 154
SER A 158
ILE A 129
VAL A 111
 None
 1.40A 1z9hA-3asuA:
undetectable		 1z9hA-3asuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		5 / 12 THR A 114
VAL A 154
SER A 158
ILE A 129
VAL A 111
 None
 1.39A 1z9hB-3asuA:
undetectable		 1z9hB-3asuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		5 / 12 THR A 114
VAL A 154
SER A 158
ILE A 129
VAL A 111
 None
 1.40A 1z9hC-3asuA:
undetectable		 1z9hC-3asuA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		4 / 4 ARG A  18
GLY A  13
GLU A  14
SER A 220
 None
 1.40A 2xctS-3asuA:
2.5
2xctU-3asuA:
2.4		 2xctS-3asuA:
17.51
2xctU-3asuA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		4 / 4 LEU A  37
ASP A  46
VAL A  27
THR A  17
 None
 1.15A 3cyxB-3asuA:
undetectable		 3cyxB-3asuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		5 / 12 ALA A  82
GLY A 109
MET A 113
ASP A 104
ALA A   8
 None
 1.24A 3ou6C-3asuA:
6.1		 3ou6C-3asuA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		5 / 9 LEU A   4
THR A  30
THR A   6
LEU A  53
ILE A  61
 None
 1.21A 5g48B-3asuA:
undetectable		 5g48B-3asuA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3asu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Escherichia
coli) 		5 / 8 THR A   6
GLY A   7
GLY A  31
LEU A  53
ALA A  51
 None
 0.92A 5vw5A-3asuA:
undetectable		 5vw5A-3asuA:
20.25