SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3at6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.9A)
HEM  A 142 (-4.8A)
HEM  A 142 (-3.8A)
HEM  A 142 (-3.3A)
 0.91A 1lh6A-3at6A:
13.4		 1lh6A-3at6A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3at6 BETA-GLOBIN
(Podocnemis
unifilis) 		4 / 7 PHE B  42
PHE B  45
VAL B  67
HIS B  92
 HEM  B 147 (-4.1A)
HEM  B 147 (-4.4A)
HEM  B 147 ( 3.9A)
HEM  B 147 (-3.5A)
 0.90A 1lh6A-3at6B:
13.3		 1lh6A-3at6B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3at6 ALPHAA-GLOBIN
BETA-GLOBIN
(Podocnemis
unifilis) 		4 / 4 ALA B 116
VAL A 111
ALA A 110
HIS A 122
 None
 1.19A 1q23K-3at6B:
undetectable		 1q23K-3at6B:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3at6 BETA-GLOBIN
(Podocnemis
unifilis) 		5 / 12 HIS B  63
ALA B  27
ILE B 109
VAL B  67
LEU B 141
 HEM  B 147 (-4.6A)
None
None
HEM  B 147 ( 3.9A)
HEM  B 147 (-4.7A)
 1.27A 1udtA-3at6B:
undetectable		 1udtA-3at6B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		5 / 10 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 142 (-3.3A)
None
HEM  A 142 (-3.5A)
 1.08A 2bxeB-3at6A:
undetectable		 2bxeB-3at6A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		4 / 4 LEU A  63
THR A  64
ILE A  55
HIS A  58
 None
None
None
HEM  A 142 (-4.7A)
 1.26A 2jfaB-3at6A:
undetectable		 2jfaB-3at6A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		4 / 8 LEU A  63
VAL A  62
VAL A 132
LEU A 129
 None
HEM  A 142 (-3.8A)
None
None
 0.76A 2zujA-3at6A:
undetectable		 2zujA-3at6A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		3 / 3 PHE A  46
SER A  52
GLN A  54
 HEM  A 142 (-4.8A)
None
None
 0.88A 3smtA-3at6A:
undetectable		 3smtA-3at6A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		5 / 12 PHE A 105
PHE A  98
HIS A  87
THR A  28
LEU A  29
 None
HEM  A 142 (-3.9A)
HEM  A 142 (-3.3A)
None
None
 1.06A 4ac0A-3at6A:
undetectable		 4ac0A-3at6A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		4 / 5 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.35A 4ifxA-3at6A:
undetectable		 4ifxA-3at6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		4 / 5 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.31A 4ig1A-3at6A:
undetectable		 4ig1A-3at6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3at6 BETA-GLOBIN
(Podocnemis
unifilis) 		6 / 12 VAL B  67
ILE B 109
VAL B 113
LEU B 110
ALA B  25
LEU B  28
 HEM  B 147 ( 3.9A)
None
None
None
None
None
 1.26A 4m11B-3at6B:
undetectable		 4m11B-3at6B:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 3at6 ALPHAA-GLOBIN
BETA-GLOBIN
(Podocnemis
unifilis) 		4 / 8 VAL A  96
LEU A 100
GLN B 131
VAL B 134
 None
 0.86A 4ma7A-3at6A:
2.5		 4ma7A-3at6A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 3at6 BETA-GLOBIN
(Podocnemis
unifilis) 		3 / 3 GLU B 101
ILE B 109
ALA B 138
 None
 0.50A 4wnwB-3at6B:
undetectable		 4wnwB-3at6B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3at6 ALPHAA-GLOBIN
(Podocnemis
unifilis) 		4 / 5 SER A 102
LYS A  99
LEU A 129
ASP A 126
 None
 1.35A 4xdtA-3at6A:
undetectable		 4xdtA-3at6A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 3at6 BETA-GLOBIN
(Podocnemis
unifilis) 		5 / 12 ALA B  62
GLY B  64
LYS B  65
LYS B  66
LEU B 106
 None
None
None
None
HEM  B 147 ( 4.8A)
 1.20A 5nwuA-3at6B:
undetectable		 5nwuA-3at6B:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 3at6 ALPHAA-GLOBIN
BETA-GLOBIN
(Podocnemis
unifilis;
Podocnemis
unifilis) 		5 / 12 THR A  39
THR A  28
VAL A 108
VAL A 107
GLN B 127
 HEM  A 142 ( 4.8A)
None
None
None
None
 1.42A 5wggA-3at6A:
undetectable		 5wggA-3at6A:
15.61