SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3at7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 5 GLU A  86
ALA A  93
SER A  97
HIS A 115
 None
 1.01A 1errA-3at7A:
undetectable
1errB-3at7A:
undetectable		 1errA-3at7A:
24.27
1errB-3at7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 10 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.11A 1pxxA-3at7A:
undetectable		 1pxxA-3at7A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.10A 1pxxC-3at7A:
undetectable		 1pxxC-3at7A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 9 ILE A  81
ILE A 148
PHE A  88
PRO A  83
ILE A 199
 None
 1.42A 2ygpA-3at7A:
undetectable		 2ygpA-3at7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		3 / 3 ARG A 116
THR A 184
THR A  52
 None
 0.59A 3k2hB-3at7A:
undetectable		 3k2hB-3at7A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 5 ILE A 148
PHE A  88
ASP A  92
GLU A  86
 None
 0.98A 3kp6A-3at7A:
1.9
3kp6B-3at7A:
undetectable		 3kp6A-3at7A:
20.36
3kp6B-3at7A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 GLY A 238
GLY A 237
ASP A 188
VAL A 257
LEU A 253
 None
 0.87A 3m6wA-3at7A:
undetectable		 3m6wA-3at7A:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.03A 3pghD-3at7A:
undetectable		 3pghD-3at7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 6 GLU A  82
GLU A  79
ARG A  98
GLU A 178
 None
 1.16A 4kr3A-3at7A:
undetectable		 4kr3A-3at7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 5 PHE A 153
PRO A 155
VAL A 158
PHE A 203
 None
 1.07A 4w5oA-3at7A:
undetectable		 4w5oA-3at7A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 5 PHE A 153
PRO A 155
VAL A 158
PHE A 203
 None
 1.04A 4z4cA-3at7A:
undetectable		 4z4cA-3at7A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 5 PHE A 153
PRO A 155
VAL A 158
PHE A 203
 None
 1.06A 4z4dA-3at7A:
undetectable		 4z4dA-3at7A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 5 PHE A 153
PRO A 155
VAL A 158
PHE A 203
 None
 1.05A 4z4eA-3at7A:
undetectable		 4z4eA-3at7A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.09A 5ikqA-3at7A:
undetectable		 5ikqA-3at7A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.10A 5ikqB-3at7A:
undetectable		 5ikqB-3at7A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.08A 5ikrB-3at7A:
undetectable		 5ikrB-3at7A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 TYR A  78
GLU A  82
GLU A 178
GLU A  79
GLU A  86
 None
 1.26A 5iqbA-3at7A:
0.4		 5iqbA-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 11 TYR A  78
GLU A  82
GLU A 178
GLU A  79
GLU A  86
 None
 1.25A 5iqbB-3at7A:
1.3		 5iqbB-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 10 ASP A 140
TYR A  78
GLU A  82
GLU A 178
GLU A  79
 None
 1.24A 5iqcC-3at7A:
1.3		 5iqcC-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 10 ASP A 140
TYR A  78
GLU A  82
GLU A 178
GLU A  86
 None
 1.09A 5iqcC-3at7A:
1.3		 5iqcC-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_A_NMYA600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 11 ASP A 140
TYR A  78
GLU A  82
GLU A 178
GLU A  79
 None
 1.21A 5iqeA-3at7A:
1.8		 5iqeA-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_B_NMYB600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 10 ASP A 140
TYR A  78
GLU A  82
GLU A 178
GLU A  79
 None
 1.22A 5iqeB-3at7A:
1.4		 5iqeB-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_C_51GC600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 10 ASP A 140
TYR A  78
GLU A  82
GLU A 178
GLU A  79
 None
 1.21A 5iqgC-3at7A:
0.0		 5iqgC-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 10 ASP A 140
TYR A  78
GLU A  82
GLU A 178
GLU A  79
 None
 1.21A 5iqgD-3at7A:
0.4		 5iqgD-3at7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		5 / 12 LEU A  87
VAL A 158
GLY A 160
ALA A 162
LEU A 165
 None
 1.07A 5jw1B-3at7A:
undetectable		 5jw1B-3at7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 6 PHE A 153
PRO A 155
VAL A 158
PHE A 203
 None
 1.05A 5t7bA-3at7A:
undetectable		 5t7bA-3at7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		3 / 3 LEU A 260
VAL A 218
ASP A 219
 None
 0.55A 5x23A-3at7A:
undetectable		 5x23A-3at7A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 8 LYS A 128
ALA A 127
LEU A 121
ALA A  67
 None
 0.82A 6mdqA-3at7A:
undetectable		 6mdqA-3at7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3at7 ALGINATE-BINDING
FLAGELLIN
(Sphingomonas
sp.
A1) 		4 / 7 ASP A  92
TYR A  78
GLU A  79
GLU A 177
 None
 0.98A 6mn5E-3at7A:
undetectable		 6mn5E-3at7A:
14.39