SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aty'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 271
ARG A 207
PHE A 206
ALA A 197
 None
 0.85A 1fiqC-3atyA:
0.0		 1fiqC-3atyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 191
SER A 243
ALA A 180
ASP A 190
ILE A 184
 None
 1.15A 1nt2A-3atyA:
undetectable		 1nt2A-3atyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 195
LEU A  27
ARG A  29
PHE A  71
ILE A 105
 FMN  A 500 (-3.6A)
FMN  A 500 (-4.4A)
None
None
None
 1.42A 1rnrA-3atyA:
undetectable		 1rnrA-3atyA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 11 GLY A 108
ARG A 130
GLU A 161
TYR A  68
GLU A 167
 None
 1.46A 2fl5A-3atyA:
undetectable
2fl5B-3atyA:
undetectable
2fl5F-3atyA:
undetectable		 2fl5A-3atyA:
19.63
2fl5B-3atyA:
19.15
2fl5F-3atyA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		6 / 12 ARG A 226
ASP A 203
ALA A 197
GLY A 255
PRO A 264
LEU A 267
 None
 1.35A 2o4nA-3atyA:
undetectable		 2o4nA-3atyA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 TYR A 282
ILE A 311
LEU A  11
LEU A  18
 None
 1.06A 2zb7A-3atyA:
undetectable		 2zb7A-3atyA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 LEU A 271
ARG A 207
PHE A 206
ALA A 197
 None
 0.87A 3ax9A-3atyA:
undetectable		 3ax9A-3atyA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 ILE A 100
HIS A  94
ARG A 245
GLY A 188
 None
 1.31A 3b9mA-3atyA:
undetectable		 3b9mA-3atyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 VAL A 177
LYS A 181
ILE A 184
GLY A 188
 None
 0.90A 3bjwF-3atyA:
undetectable		 3bjwF-3atyA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 139
THR A 156
ILE A 144
PRO A 145
PHE A 148
 None
 0.77A 3clbB-3atyA:
undetectable		 3clbB-3atyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 4 ARG A 213
ASP A 166
ASP A 165
PRO A 217
 None
 1.48A 3fgrB-3atyA:
undetectable		 3fgrB-3atyA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 HIS A 106
LEU A 132
ALA A 128
PRO A  66
 None
 1.21A 3gv1A-3atyA:
undetectable
3gv1C-3atyA:
undetectable		 3gv1A-3atyA:
19.10
3gv1C-3atyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 132
ALA A 128
PRO A  66
HIS A 106
 None
 1.24A 3gv1A-3atyA:
undetectable
3gv1B-3atyA:
undetectable		 3gv1A-3atyA:
19.10
3gv1B-3atyA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 TYR A 157
GLY A  70
ALA A 110
ALA A  61
ILE A 144
 None
None
None
FMN  A 500 (-3.1A)
None
 1.07A 3jayA-3atyA:
undetectable		 3jayA-3atyA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 5 SER A 210
ARG A 207
ARG A 249
GLY A 196
GLU A 193
 None
None
FMN  A 500 (-2.9A)
None
None
 1.50A 3k9fA-3atyA:
undetectable
3k9fB-3atyA:
undetectable
3k9fC-3atyA:
undetectable		 3k9fA-3atyA:
22.64
3k9fB-3atyA:
22.64
3k9fC-3atyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 6 ARG A 207
SER A 210
ARG A 249
GLY A 196
GLU A 193
 None
None
FMN  A 500 (-2.9A)
None
None
 1.49A 3k9fA-3atyA:
undetectable
3k9fB-3atyA:
undetectable
3k9fD-3atyA:
undetectable		 3k9fA-3atyA:
22.64
3k9fB-3atyA:
22.64
3k9fD-3atyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ARG A 226
ALA A 197
GLY A 255
PRO A 264
LEU A 267
 None
 1.22A 3u7sB-3atyA:
undetectable		 3u7sB-3atyA:
13.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		6 / 9 THR A  28
ALA A  61
ILE A 105
HIS A 195
TYR A 200
TYR A 364
 FMN  A 500 (-3.7A)
FMN  A 500 (-3.1A)
None
FMN  A 500 (-3.6A)
None
FMN  A 500 (-4.1A)
 0.29A 3upwA-3atyA:
47.3		 3upwA-3atyA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 ARG A 109
VAL A 256
VAL A 291
ASP A 203
 None
 1.11A 3uy4A-3atyA:
2.1		 3uy4A-3atyA:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ALA A  25
PRO A  26
GLN A 103
ARG A 249
ASN A 313
 FMN  A 500 (-3.5A)
FMN  A 500 (-4.0A)
FMN  A 500 (-3.0A)
FMN  A 500 (-2.9A)
FMN  A 500 (-2.9A)
 1.39A 4a3uA-3atyA:
54.1		 4a3uA-3atyA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_ACTA1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 9 ALA A  25
PRO A  26
ILE A  58
ARG A 249
ASN A 313
 FMN  A 500 (-3.5A)
FMN  A 500 (-4.0A)
None
FMN  A 500 (-2.9A)
FMN  A 500 (-2.9A)
 0.31A 4a3uA-3atyA:
54.1		 4a3uA-3atyA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 7 THR A  28
HIS A 195
ASN A 198
TYR A 200
TYR A 364
 FMN  A 500 (-3.7A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.2A)
None
FMN  A 500 (-4.1A)
 0.33A 4a3uA-3atyA:
54.1		 4a3uA-3atyA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 7 THR A  28
HIS A 195
ASN A 198
TYR A 200
TYR A 364
 FMN  A 500 (-3.7A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.2A)
None
FMN  A 500 (-4.1A)
 0.32A 4a3uB-3atyA:
54.2		 4a3uB-3atyA:
40.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 7 THR A  28
HIS A 195
ASN A 198
TYR A 200
 FMN  A 500 (-3.7A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.2A)
None
 0.22A 4awuA-3atyA:
53.2		 4awuA-3atyA:
37.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 THR A  28
HIS A 195
TYR A 200
TYR A 364
 FMN  A 500 (-3.7A)
FMN  A 500 (-3.6A)
None
FMN  A 500 (-4.1A)
 0.29A 4df2A-3atyA:
47.2		 4df2A-3atyA:
32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 6 PRO A  26
ARG A 249
GLY A 196
ALA A  61
 FMN  A 500 (-4.0A)
FMN  A 500 (-2.9A)
None
FMN  A 500 (-3.1A)
 1.00A 4g0uA-3atyA:
undetectable		 4g0uA-3atyA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 GLY A 199
GLY A 255
ILE A 260
LEU A 253
 None
 0.81A 4mwzB-3atyA:
undetectable		 4mwzB-3atyA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 5 ARG A 249
GLY A 196
GLU A 193
SER A 210
 FMN  A 500 (-2.9A)
None
None
None
 1.21A 4z3oA-3atyA:
undetectable
4z3oB-3atyA:
undetectable		 4z3oA-3atyA:
19.92
4z3oB-3atyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  99
LEU A  11
ILE A  23
LYS A 310
ALA A 332
 None
 1.00A 5eypB-3atyA:
4.3		 5eypB-3atyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 4 LEU A 283
LEU A 280
GLY A 247
GLU A 193
 None
 1.27A 5hhjA-3atyA:
undetectable		 5hhjA-3atyA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 100
LEU A  18
GLY A 191
PHE A 189
ILE A  58
 None
 1.06A 5j7wC-3atyA:
undetectable		 5j7wC-3atyA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 100
LEU A  18
GLY A 191
PHE A 189
ILE A  58
 None
 1.09A 5j7wD-3atyA:
undetectable		 5j7wD-3atyA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 HIS A 195
ASN A 198
TYR A 200
TYR A 147
 FMN  A 500 (-3.6A)
FMN  A 500 (-4.2A)
None
None
 0.72A 5v4vA-3atyA:
50.2		 5v4vA-3atyA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 8 THR A  28
HIS A 195
ASN A 198
TYR A 200
TYR A 364
 FMN  A 500 (-3.7A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.2A)
None
FMN  A 500 (-4.1A)
 0.31A 5v4vA-3atyA:
50.2		 5v4vA-3atyA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		4 / 8 HIS A 195
ASN A 198
TYR A 200
TYR A 147
 FMN  A 500 (-3.6A)
FMN  A 500 (-4.2A)
None
None
 0.72A 5v4vB-3atyA:
50.2		 5v4vB-3atyA:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3aty PROSTAGLANDIN F2A
SYNTHASE
(Trypanosoma
cruzi) 		5 / 8 THR A  28
HIS A 195
ASN A 198
TYR A 200
TYR A 364
 FMN  A 500 (-3.7A)
FMN  A 500 (-3.6A)
FMN  A 500 (-4.2A)
None
FMN  A 500 (-4.1A)
 0.29A 5v4vB-3atyA:
50.2		 5v4vB-3atyA:
33.88