SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3au7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 318
LEU A 313
LEU A 314
 None
 0.73A 1ikeA-3au7A:
undetectable		 1ikeA-3au7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 387
GLY A 317
ASP A 318
 None
 0.59A 1kf6A-3au7A:
undetectable
1kf6B-3au7A:
undetectable		 1kf6A-3au7A:
21.32
1kf6B-3au7A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 318
LEU A 313
LEU A 314
 None
 0.75A 1np1B-3au7A:
undetectable		 1np1B-3au7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 ARG A 217
ALA A 247
ILE A 409
PRO A 407
 AG2  A7011 (-3.5A)
None
None
None
 1.20A 1oniB-3au7A:
undetectable
1oniC-3au7A:
undetectable		 1oniB-3au7A:
17.77
1oniC-3au7A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 LEU A 333
PHE A 287
ILE A 338
GLY A 324
 None
 1.02A 2v0mC-3au7A:
undetectable		 2v0mC-3au7A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 ARG A 217
GLY A 218
SER A 230
 AG2  A7011 (-3.5A)
None
None
 0.64A 2xctB-3au7A:
undetectable		 2xctB-3au7A:
20.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 5 GLU A 159
ASN A 194
VAL A 203
CYH A 204
ARG A 217
 AG2  A7011 ( 4.1A)
AG2  A7011 (-4.5A)
AG2  A7011 (-4.5A)
None
AG2  A7011 (-3.5A)
 0.33A 3amuA-3au7A:
51.7		 3amuA-3au7A:
90.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 148
ALA A  58
ALA A 147
VAL A  75
ILE A  79
 None
 0.99A 3h0aA-3au7A:
undetectable		 3h0aA-3au7A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 CYH A 204
PRO A 398
ASP A 184
 None
 0.94A 3hlwB-3au7A:
undetectable		 3hlwB-3au7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 ASP A 318
ARG A 315
ALA A 342
 None
 0.78A 3mbgC-3au7A:
undetectable		 3mbgC-3au7A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 150
TRP A   4
VAL A  97
 None
 0.61A 3n62B-3au7A:
undetectable		 3n62B-3au7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 150
TRP A   4
VAL A  97
 None
 0.60A 3n65B-3au7A:
undetectable		 3n65B-3au7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 150
TRP A   4
VAL A  97
 None
 0.62A 3n66B-3au7A:
undetectable		 3n66B-3au7A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 GLY A 144
ALA A 145
GLY A 139
ILE A 119
VAL A 125
 None
 0.98A 3nu9B-3au7A:
undetectable		 3nu9B-3au7A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 THR A  48
ASP A 115
VAL A 258
ILE A 253
GLU A 256
 None
 1.32A 4i41A-3au7A:
undetectable		 4i41A-3au7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 CYH A 204
PRO A 398
ASP A 184
 None
 0.92A 4pm5A-3au7A:
undetectable		 4pm5A-3au7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 141
GLY A 144
LEU A 117
ILE A   7
ILE A 119
 None
 1.02A 4qtuB-3au7A:
undetectable		 4qtuB-3au7A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 PHE A 307
ILE A 289
LEU A 314
PHE A 287
 None
 0.83A 4uymA-3au7A:
undetectable		 4uymA-3au7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		6 / 12 GLY A 144
GLY A 141
ASP A   8
ILE A  43
LEU A 117
LEU A  45
 None
 1.14A 5bw4A-3au7A:
undetectable		 5bw4A-3au7A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 261
GLU A 255
ARG A 270
GLY A 271
ILE A 289
 None
 1.17A 5ifuA-3au7A:
undetectable		 5ifuA-3au7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 9 GLY A 144
ALA A 145
GLY A 139
ILE A 119
VAL A 125
 None
 1.00A 5kr0B-3au7A:
undetectable		 5kr0B-3au7A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 VAL A  59
GLY A  57
LEU A  21
THR A  19
ALA A  22
 None
 0.91A 5vm8B-3au7A:
undetectable		 5vm8B-3au7A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 150
TRP A   4
VAL A  97
 None
 0.63A 5vuoB-3au7A:
undetectable		 5vuoB-3au7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 336
PHE A 287
PRO A 303
THR A 304
 None
 0.91A 5x23A-3au7A:
undetectable		 5x23A-3au7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 119
GLY A 144
ASN A  46
ALA A 147
ALA A 109
 None
 1.07A 5zw4A-3au7A:
undetectable		 5zw4A-3au7A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 5 GLU A 159
ASN A 194
VAL A 203
CYH A 204
ARG A 217
 AG2  A7011 ( 4.1A)
AG2  A7011 (-4.5A)
AG2  A7011 (-4.5A)
None
AG2  A7011 (-3.5A)
 0.34A 6aggZ-3au7A:
51.9		 6aggZ-3au7A:
80.00