SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3au9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		3 / 3 ASP A 326
PHE A 321
ASN A 255
 None
 0.88A 1sg9B-3au9A:
2.5		 1sg9B-3au9A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 7 TYR A 366
THR A 319
GLU A 315
SER A 342
 None
None
MG  A 601 ( 2.6A)
None
 1.23A 1tv8B-3au9A:
undetectable		 1tv8B-3au9A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 6 LEU A 187
HIS A 471
ASN A 420
ILE A 467
 None
 0.90A 1xf1B-3au9A:
undetectable		 1xf1B-3au9A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 396
VAL A 334
HIS A 392
ALA A 307
PHE A 274
 None
 1.39A 2g70B-3au9A:
undetectable		 2g70B-3au9A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 419
ILE A 444
VAL A 316
THR A 308
ASP A 305
 None
 1.30A 2qo4A-3au9A:
undetectable		 2qo4A-3au9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 419
ILE A 444
VAL A 316
THR A 308
ASP A 305
 None
 1.31A 2qo6A-3au9A:
undetectable		 2qo6A-3au9A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 7 VAL A 332
TYR A 327
TYR A 406
ILE A 265
 None
 1.36A 2xz5B-3au9A:
undetectable
2xz5E-3au9A:
undetectable		 2xz5B-3au9A:
19.86
2xz5E-3au9A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 TYR A 132
GLY A 164
LEU A 159
PHE A  83
CYH A 169
 None
 1.11A 3e23A-3au9A:
2.7		 3e23A-3au9A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 8 VAL A 334
HIS A 392
PHE A 399
PRO A 294
 None
 1.14A 3v35A-3au9A:
undetectable		 3v35A-3au9A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 8 SER A  85
ARG A  98
ILE A  82
PHE A 128
 None
 1.15A 4cx7A-3au9A:
undetectable
4cx7B-3au9A:
undetectable		 4cx7A-3au9A:
21.84
4cx7B-3au9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 8 SER A  85
ARG A  98
ILE A  82
PHE A 128
 None
 1.17A 4cx7C-3au9A:
undetectable
4cx7D-3au9A:
undetectable		 4cx7C-3au9A:
21.84
4cx7D-3au9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 1.01A 4ej1A-3au9A:
undetectable		 4ej1A-3au9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 1.02A 4kjjA-3au9A:
undetectable		 4kjjA-3au9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 0.98A 4kjkA-3au9A:
undetectable		 4kjkA-3au9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 1.05A 4kjlA-3au9A:
undetectable		 4kjlA-3au9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 8 LEU A 252
MET A 464
LEU A 187
ILE A 177
 None
 1.05A 4ok1A-3au9A:
undetectable		 4ok1A-3au9A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 1.00A 4p3qA-3au9A:
undetectable		 4p3qA-3au9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 1.00A 4p3rA-3au9A:
undetectable		 4p3rA-3au9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 1.01A 4pthA-3au9A:
undetectable		 4pthA-3au9A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 7 GLY A 186
GLN A 185
SER A 207
ASN A 204
 None
NDP  A 501 (-4.0A)
None
NDP  A 501 (-3.8A)
 1.16A 4ws0A-3au9A:
undetectable		 4ws0A-3au9A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 0.99A 4x5gB-3au9A:
undetectable		 4x5gB-3au9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 159
ILE A  82
LEU A  94
GLY A  84
GLY A 161
 None
None
None
NDP  A 501 (-3.6A)
None
 1.14A 5d4uA-3au9A:
3.1		 5d4uA-3au9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 6 HIS A 471
GLU A 206
ALA A 426
LEU A 429
 None
NDP  A 501 (-3.2A)
None
None
 1.04A 5igiA-3au9A:
undetectable		 5igiA-3au9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 LEU A 368
ILE A 227
TRP A 296
ILE A  89
VAL A 178
 None
None
FOM  A 701 (-3.8A)
NDP  A 501 (-4.4A)
None
 1.05A 5mugA-3au9A:
2.1		 5mugA-3au9A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 6 ILE A 302
ILE A 237
LEU A 267
PHE A 256
 NDP  A 501 (-4.3A)
None
None
None
 1.04A 5vkqB-3au9A:
undetectable
5vkqC-3au9A:
undetectable		 5vkqB-3au9A:
14.63
5vkqC-3au9A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 186
LEU A 219
GLY A 212
SER A 210
ILE A 208
 None
 1.13A 5vooA-3au9A:
undetectable		 5vooA-3au9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 186
LEU A 219
GLY A 212
SER A 210
ILE A 208
 None
 1.08A 5vooB-3au9A:
undetectable		 5vooB-3au9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 186
LEU A 219
GLY A 212
SER A 210
ILE A 208
 None
 1.12A 5vooC-3au9A:
undetectable		 5vooC-3au9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 186
LEU A 219
GLY A 212
SER A 210
ILE A 208
 None
 1.10A 5vooD-3au9A:
undetectable		 5vooD-3au9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 186
LEU A 219
GLY A 212
SER A 210
ILE A 208
 None
 1.17A 5vooF-3au9A:
2.4		 5vooF-3au9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 GLY A 186
LEU A 219
GLY A 212
SER A 210
ILE A 208
 None
 1.12A 5vopB-3au9A:
undetectable		 5vopB-3au9A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		4 / 6 MET A 464
ASN A 413
LEU A 468
GLN A 454
 None
 1.49A 5xdhA-3au9A:
undetectable
5xdhC-3au9A:
0.0		 5xdhA-3au9A:
10.65
5xdhC-3au9A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 0.98A 5z6jA-3au9A:
undetectable		 5z6jA-3au9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 0.96A 5z6kA-3au9A:
undetectable		 5z6kA-3au9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3au9 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE
(Plasmodium
falciparum) 		5 / 12 ILE A 228
THR A 190
ILE A 194
LEU A 219
ILE A 227
 None
 1.09A 7dfrA-3au9A:
undetectable		 7dfrA-3au9A:
16.78