SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3auf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 12 ILE A   8
ALA A  54
LEU A  19
ILE A   4
PRO A 179
 None
 1.11A 1jolB-3aufA:
undetectable		 1jolB-3aufA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 5 ILE A 105
LEU A 106
VAL A 137
ALA A 153
CYH A 135
 None
 1.41A 1mz9C-3aufA:
undetectable		 1mz9C-3aufA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 6 ILE A 108
PRO A 110
GLU A 174
ARG A 167
 None
 1.37A 1oniA-3aufA:
undetectable
1oniC-3aufA:
undetectable		 1oniA-3aufA:
21.55
1oniC-3aufA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 5 ARG A 167
ILE A 108
PRO A 110
GLU A 174
 None
 1.37A 1oniG-3aufA:
undetectable
1oniH-3aufA:
undetectable		 1oniG-3aufA:
21.55
1oniH-3aufA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		3 / 3 LEU A   7
ARG A  91
ILE A   8
 None
 0.60A 2xn5B-3aufA:
undetectable		 2xn5B-3aufA:
10.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 8 LEU A  98
ASN A 107
VAL A 140
GLY A 143
 None
 0.69A 3dcjB-3aufA:
30.2		 3dcjB-3aufA:
38.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 12 GLY A  88
ASN A  14
GLN A 122
CYH A 135
ILE A 170
 None
 1.20A 3opeA-3aufA:
undetectable		 3opeA-3aufA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 5 ASP A  20
LEU A  19
ILE A 182
PRO A 179
 None
 1.21A 3s3vA-3aufA:
undetectable		 3s3vA-3aufA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 12 VAL A 197
ILE A 149
GLN A 152
ILE A 177
GLU A 180
 None
 1.29A 4a99A-3aufA:
4.7
4a99C-3aufA:
4.3		 4a99A-3aufA:
24.94
4a99C-3aufA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 5 ILE A 149
GLN A 152
ILE A 177
GLU A 180
 None
 1.02A 4a99D-3aufA:
4.3		 4a99D-3aufA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 5 ILE A 108
ALA A 181
HIS A 175
ARG A 176
 None
 1.22A 4ac9B-3aufA:
3.6
4ac9C-3aufA:
3.2		 4ac9B-3aufA:
21.47
4ac9C-3aufA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 5 ILE A 108
ALA A 181
HIS A 175
ARG A 176
 None
 1.21A 4acaB-3aufA:
3.1
4acaC-3aufA:
2.2		 4acaB-3aufA:
21.47
4acaC-3aufA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		4 / 8 ILE A   8
GLY A  10
GLN A  16
ARG A  23
 None
 0.74A 4acbB-3aufA:
4.0
4acbC-3aufA:
4.4		 4acbB-3aufA:
21.47
4acbC-3aufA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 10 ASP A  37
VAL A  34
ALA A  54
GLY A  88
GLY A  43
 None
 1.26A 4mmdA-3aufA:
undetectable		 4mmdA-3aufA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 12 GLY A   5
ASP A  69
VAL A  93
ALA A  87
LEU A  86
 None
 1.06A 5kocA-3aufA:
2.8		 5kocA-3aufA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		6 / 11 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
ALA A  17
 None
 1.44A 5lg3A-3aufA:
undetectable		 5lg3A-3aufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		6 / 12 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
ALA A  17
 None
 1.38A 5lg3E-3aufA:
undetectable		 5lg3E-3aufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 10 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
 None
 1.26A 5lg3F-3aufA:
undetectable		 5lg3F-3aufA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1
(Symbiobacterium
toebii) 		5 / 10 ILE A   4
ILE A 182
VAL A   6
ASN A  14
GLU A 174
 None
 1.25A 5lg3G-3aufA:
undetectable		 5lg3G-3aufA:
22.93