SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3auo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 ASP A 511
ASP A 512
TYR A  38
ARG A  35
 None
None
None
DG3  A 576 (-3.6A)
 1.48A 1ceaA-3auoA:
undetectable
1ceaB-3auoA:
undetectable		 1ceaA-3auoA:
9.89
1ceaB-3auoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 ASP A 511
ASP A 512
TYR A  38
ARG A  35
 None
None
None
DG3  A 576 (-3.6A)
 1.49A 1ceaB-3auoA:
undetectable		 1ceaB-3auoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 ASP A 511
ASP A 512
TYR A  38
ARG A  35
 None
None
None
DG3  A 576 (-3.6A)
 1.49A 1cebA-3auoA:
undetectable		 1cebA-3auoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 ASP A 511
ASP A 512
TYR A  38
ARG A  35
 None
None
None
DG3  A 576 (-3.6A)
 1.45A 1cebB-3auoA:
undetectable		 1cebB-3auoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 GLU A 184
ARG A 190
LEU A 256
GLU A 297
 None
 0.94A 1cmaA-3auoA:
undetectable
1cmaB-3auoA:
undetectable		 1cmaA-3auoA:
11.69
1cmaB-3auoA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 10 ILE A 416
GLU A 459
LEU A 458
LYS A 494
VAL A 496
 None
 1.10A 1cqpA-3auoA:
undetectable
1cqpB-3auoA:
undetectable		 1cqpA-3auoA:
14.31
1cqpB-3auoA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 ALA A 183
GLU A 184
LEU A 202
VAL A 247
 None
 0.89A 1hk2A-3auoA:
undetectable		 1hk2A-3auoA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 GLU A 413
HIS A 374
HIS A 468
TYR A 503
ASP A 501
 ZN  A 579 (-2.2A)
None
ZN  A 579 (-3.4A)
None
None
 1.15A 1ituA-3auoA:
7.4		 1ituA-3auoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 GLU A 413
HIS A 374
HIS A 468
TYR A 503
ASP A 501
 ZN  A 579 (-2.2A)
None
ZN  A 579 (-3.4A)
None
None
 1.15A 1ituB-3auoA:
8.4		 1ituB-3auoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 HIS A 468
THR A 372
HIS A 344
HIS A 531
HIS A 440
 ZN  A 579 (-3.4A)
None
None
None
ZN  A 579 (-4.1A)
 1.49A 1j36A-3auoA:
undetectable		 1j36A-3auoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 HIS A 468
THR A 372
HIS A 344
HIS A 531
HIS A 440
 ZN  A 579 (-3.4A)
None
None
None
ZN  A 579 (-4.1A)
 1.50A 1j36B-3auoA:
undetectable		 1j36B-3auoA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ARG A 190
ARG A 182
ARG A 314
 None
 1.00A 1l7fA-3auoA:
undetectable		 1l7fA-3auoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ARG A 190
ARG A 182
ARG A 314
 None
 1.02A 1l7hA-3auoA:
undetectable		 1l7hA-3auoA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MSK_A_SAMA1301_0
(COBALAMIN-DEPENDENT
METHIONINE SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 10 ASP A 529
ARG A 506
PRO A 376
ALA A 377
ALA A 381
 ZN  A 579 ( 4.1A)
ZN  A 579 ( 4.3A)
None
None
None
 1.20A 1mskA-3auoA:
0.0		 1mskA-3auoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 6 LEU A 566
ASP A 433
LEU A 434
GLY A 411
ILE A 396
 None
 1.26A 1mt1G-3auoA:
undetectable
1mt1J-3auoA:
undetectable		 1mt1G-3auoA:
8.00
1mt1J-3auoA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 8 LEU A 566
ASP A 433
LEU A 434
GLY A 411
ILE A 396
 None
 1.22A 1n13A-3auoA:
undetectable
1n13F-3auoA:
undetectable		 1n13A-3auoA:
8.00
1n13F-3auoA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ASP A 349
HIS A 344
HIS A 374
 None
 0.62A 1oe1A-3auoA:
undetectable		 1oe1A-3auoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ASP A 349
HIS A 344
HIS A 374
 None
 0.62A 1oe3A-3auoA:
undetectable		 1oe3A-3auoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 4 HIS A 374
GLU A 413
HIS A 344
HIS A 531
 None
ZN  A 579 (-2.2A)
None
None
 1.21A 1uttA-3auoA:
undetectable		 1uttA-3auoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 4 HIS A 374
GLU A 413
HIS A 344
HIS A 531
 None
ZN  A 579 (-2.2A)
None
None
 1.17A 1utzA-3auoA:
undetectable		 1utzA-3auoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 4 HIS A 374
GLU A 413
HIS A 344
HIS A 531
 None
ZN  A 579 (-2.2A)
None
None
 1.17A 1utzB-3auoA:
undetectable		 1utzB-3auoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 551
LEU A 332
ALA A 514
SER A 525
LEU A 341
 None
 1.32A 2a58A-3auoA:
undetectable
2a58B-3auoA:
undetectable		 2a58A-3auoA:
15.71
2a58B-3auoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 551
LEU A 332
ALA A 514
SER A 525
LEU A 341
 None
 1.32A 2a58B-3auoA:
undetectable
2a58C-3auoA:
undetectable		 2a58B-3auoA:
15.71
2a58C-3auoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 551
LEU A 332
ALA A 514
SER A 525
LEU A 341
 None
 1.32A 2a58D-3auoA:
undetectable
2a58E-3auoA:
undetectable		 2a58D-3auoA:
15.71
2a58E-3auoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ALA A 530
LEU A 357
ASP A 340
ILE A 396
THR A 528
 None
 1.13A 2bl9A-3auoA:
undetectable		 2bl9A-3auoA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 10 GLY A 411
LEU A 432
ARG A 397
TYR A 562
TYR A 407
 None
 1.12A 2h21A-3auoA:
undetectable		 2h21A-3auoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 11 GLY A 411
LEU A 432
ARG A 397
TYR A 562
TYR A 407
 None
 1.18A 2h21B-3auoA:
undetectable		 2h21B-3auoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 11 GLY A 411
LEU A 432
ARG A 397
TYR A 562
TYR A 407
 None
 1.20A 2h21C-3auoA:
undetectable		 2h21C-3auoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 4 HIS A 374
GLU A 413
HIS A 344
HIS A 531
 None
ZN  A 579 (-2.2A)
None
None
 1.15A 2ow9B-3auoA:
undetectable		 2ow9B-3auoA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 4 HIS A 374
GLU A 413
HIS A 344
HIS A 531
 None
ZN  A 579 (-2.2A)
None
None
 1.18A 2ozrE-3auoA:
undetectable		 2ozrE-3auoA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 8 ILE A 396
LEU A 566
ASP A 433
LEU A 434
GLY A 411
 None
 1.22A 2qqcH-3auoA:
undetectable
2qqcK-3auoA:
undetectable		 2qqcH-3auoA:
12.11
2qqcK-3auoA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 LEU A 130
LEU A 133
ILE A 144
ARG A 140
 None
 0.98A 2rlfB-3auoA:
undetectable
2rlfC-3auoA:
undetectable		 2rlfB-3auoA:
6.14
2rlfC-3auoA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 LEU A 513
PRO A 469
LEU A 466
ALA A 491
 None
 0.91A 2vcvG-3auoA:
undetectable		 2vcvG-3auoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 LEU A 513
PRO A 469
LEU A 466
ALA A 491
 None
 0.98A 2vcvK-3auoA:
undetectable		 2vcvK-3auoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ASP A 349
HIS A 344
HIS A 374
 None
 0.63A 2xxgA-3auoA:
undetectable		 2xxgA-3auoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ASP A 349
HIS A 344
HIS A 374
 None
 0.67A 2xxgC-3auoA:
undetectable		 2xxgC-3auoA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 TYR A 301
LEU A 304
GLY A 326
ALA A 322
 None
 0.82A 3jusA-3auoA:
undetectable		 3jusA-3auoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 TYR A 301
LEU A 304
GLY A 326
ALA A 322
 None
 0.82A 3jusA-3auoA:
undetectable		 3jusA-3auoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 TYR A 301
LEU A 304
GLY A 326
ALA A 322
 None
 0.79A 3jusB-3auoA:
undetectable		 3jusB-3auoA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ASN A 558
ASP A 340
ARG A 472
 None
 0.91A 3k13C-3auoA:
4.8		 3k13C-3auoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 GLY A 350
THR A 346
ASN A 352
 None
 0.63A 3v4tD-3auoA:
undetectable		 3v4tD-3auoA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 GLY A 411
ALA A 412
ASP A 373
PRO A 425
 None
 0.86A 4eyrB-3auoA:
undetectable		 4eyrB-3auoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 ASP A 505
ASP A 349
ASP A 529
ASP A 415
 None
None
ZN  A 579 ( 4.1A)
None
 1.00A 4gkhC-3auoA:
1.1
4gkhK-3auoA:
undetectable		 4gkhC-3auoA:
19.03
4gkhK-3auoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 ASP A 505
ASP A 349
ASP A 529
ASP A 415
 None
None
ZN  A 579 ( 4.1A)
None
 1.02A 4gkiE-3auoA:
undetectable
4gkiG-3auoA:
undetectable		 4gkiE-3auoA:
19.03
4gkiG-3auoA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 LEU A  58
PRO A  59
ARG A   2
 None
 0.58A 4klrB-3auoA:
undetectable		 4klrB-3auoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 11 GLY A 411
ALA A 412
ASP A 373
PRO A 425
VAL A 414
 None
 1.10A 4l1aA-3auoA:
undetectable		 4l1aA-3auoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 PHE A 286
ALA A 254
SER A 251
ARG A 291
 None
 1.20A 4lv9A-3auoA:
2.8
4lv9B-3auoA:
2.8		 4lv9A-3auoA:
22.46
4lv9B-3auoA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 ASP A 200
ALA A 226
TYR A 225
ASP A 198
 DG3  A 576 (-2.6A)
None
None
MG  A 577 (-2.8A)
 1.15A 4mdaA-3auoA:
undetectable		 4mdaA-3auoA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 ASP A 200
ALA A 226
TYR A 225
ASP A 198
 DG3  A 576 (-2.6A)
None
None
MG  A 577 (-2.8A)
 1.17A 4mdbA-3auoA:
undetectable		 4mdbA-3auoA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		6 / 9 LEU A 422
GLY A 420
HIS A 417
VAL A 437
SER A 438
VAL A 414
 None
None
None
None
ZN  A 579 ( 4.4A)
None
 1.44A 4qd3A-3auoA:
undetectable		 4qd3A-3auoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ALA A 471
HIS A 344
HIS A 374
GLU A 413
LEU A 454
 None
None
None
ZN  A 579 (-2.2A)
None
 1.08A 4r7lA-3auoA:
2.1		 4r7lA-3auoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ALA A 530
HIS A 440
HIS A 468
GLU A 413
LEU A 369
 None
ZN  A 579 (-4.1A)
ZN  A 579 (-3.4A)
ZN  A 579 (-2.2A)
None
 1.22A 4r7lA-3auoA:
2.1		 4r7lA-3auoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_J_SPMJ202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 GLU A 298
TYR A 252
GLU A 297
ARG A 182
 None
 1.24A 4r87J-3auoA:
undetectable
4r87L-3auoA:
undetectable		 4r87J-3auoA:
15.49
4r87L-3auoA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 4 ALA A 467
VAL A 414
GLY A 411
THR A 372
 None
 1.14A 4ubeA-3auoA:
undetectable		 4ubeA-3auoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 ASP A 198
LEU A 259
GLY A 187
 MG  A 577 (-2.8A)
DG3  A 576 (-4.8A)
DG3  A 576 (-3.4A)
 0.54A 4xmfA-3auoA:
undetectable		 4xmfA-3auoA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 ARG A 472
ARG A 548
ASP A 194
ASP A 512
 None
 1.21A 4xqeA-3auoA:
undetectable		 4xqeA-3auoA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 ARG A 472
ARG A 548
ASP A 194
ASP A 512
 None
 1.25A 4xqeB-3auoA:
undetectable		 4xqeB-3auoA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 LEU A 202
GLY A 255
ALA A 254
SER A 251
 None
 0.75A 5f1aA-3auoA:
undetectable		 5f1aA-3auoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 7 LEU A 202
GLY A 255
ALA A 254
SER A 251
 None
 0.76A 5f1aB-3auoA:
undetectable		 5f1aB-3auoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 9 ALA A 549
ASP A 511
ILE A 500
GLY A 544
PRO A 553
 None
 1.21A 5kr2A-3auoA:
undetectable		 5kr2A-3auoA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 GLY A 411
TYR A 368
ALA A 389
ALA A 412
TYR A 424
 None
 1.18A 5kvaA-3auoA:
undetectable		 5kvaA-3auoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 GLY A 411
TYR A 368
ALA A 389
ALA A 412
TYR A 424
 None
 1.17A 5kvaB-3auoA:
undetectable		 5kvaB-3auoA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.02A 5n0oA-3auoA:
undetectable		 5n0oA-3auoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.04A 5n0rA-3auoA:
undetectable		 5n0rA-3auoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.04A 5n0sA-3auoA:
undetectable		 5n0sA-3auoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.06A 5n0sB-3auoA:
undetectable		 5n0sB-3auoA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.03A 5n0tA-3auoA:
undetectable		 5n0tA-3auoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.02A 5n0wA-3auoA:
undetectable		 5n0wA-3auoA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.01A 5n0wB-3auoA:
undetectable		 5n0wB-3auoA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 ILE A 174
VAL A 242
VAL A 234
ALA A 183
VAL A 246
 None
 1.01A 5n4iA-3auoA:
undetectable		 5n4iA-3auoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 12 GLY A 411
TYR A 368
ALA A 389
ALA A 412
TYR A 424
 None
 1.20A 5n5dA-3auoA:
undetectable		 5n5dA-3auoA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 ASP A 349
HIS A 531
HIS A 344
HIS A 440
 None
None
None
ZN  A 579 (-4.1A)
 0.92A 5ncdA-3auoA:
2.3
5ncdD-3auoA:
3.0		 5ncdA-3auoA:
19.19
5ncdD-3auoA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 HIS A 440
ASP A 349
HIS A 531
HIS A 344
 ZN  A 579 (-4.1A)
None
None
None
 0.90A 5ncdB-3auoA:
3.6
5ncdC-3auoA:
2.6		 5ncdB-3auoA:
19.19
5ncdC-3auoA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 HIS A 440
ASP A 529
HIS A 344
HIS A 468
 ZN  A 579 (-4.1A)
ZN  A 579 ( 4.1A)
None
ZN  A 579 (-3.4A)
 0.92A 5ncdB-3auoA:
3.6
5ncdC-3auoA:
2.6		 5ncdB-3auoA:
19.19
5ncdC-3auoA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 6 ASP A 529
HIS A 344
HIS A 468
HIS A 440
 ZN  A 579 ( 4.1A)
None
ZN  A 579 (-3.4A)
ZN  A 579 (-4.1A)
 0.88A 5nelA-3auoA:
2.7
5nelD-3auoA:
3.9		 5nelA-3auoA:
19.19
5nelD-3auoA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 374
ASP A 349
HIS A 531
 None
 0.81A 5oexA-3auoA:
undetectable		 5oexA-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 531
ASP A 349
HIS A 374
 None
 0.44A 5oexA-3auoA:
undetectable		 5oexA-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 374
ASP A 349
HIS A 531
 None
 0.73A 5oexB-3auoA:
undetectable		 5oexB-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 531
ASP A 349
HIS A 374
 None
 0.51A 5oexB-3auoA:
undetectable		 5oexB-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 374
ASP A 349
HIS A 531
 None
 0.69A 5oexC-3auoA:
undetectable		 5oexC-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 531
ASP A 349
HIS A 374
 None
 0.51A 5oexC-3auoA:
undetectable		 5oexC-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 374
ASP A 349
HIS A 531
 None
 0.70A 5oexD-3auoA:
undetectable		 5oexD-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		3 / 3 HIS A 531
ASP A 349
HIS A 374
 None
 0.48A 5oexD-3auoA:
undetectable		 5oexD-3auoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 4 ASP A 373
SER A 348
ASP A 349
HIS A 531
 None
 1.33A 5wyqB-3auoA:
undetectable		 5wyqB-3auoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 11 ASP A 529
ARG A 506
PRO A 376
ALA A 377
ALA A 381
 ZN  A 579 ( 4.1A)
ZN  A 579 ( 4.3A)
None
None
None
 1.19A 6bm5A-3auoA:
undetectable		 6bm5A-3auoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		4 / 8 LEU A 306
LEU A 324
LEU A 278
GLY A 277
 None
 0.95A 6ce2A-3auoA:
undetectable		 6ce2A-3auoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)
(Thermus
thermophilus) 		5 / 11 TYR A 192
LEU A 541
GLU A 540
ALA A 167
LEU A 199
 None
 1.38A 6dk1B-3auoA:
undetectable		 6dk1B-3auoA:
17.05