SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3aut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3aut GLUCOSE
1-DEHYDROGENASE 4
(Bacillus
megaterium) 		4 / 6 ARG A 125
ASP A 114
ASN A 110
ASP A 107
 None
 1.25A 2okcA-3autA:
5.3		 2okcA-3autA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3aut GLUCOSE
1-DEHYDROGENASE 4
(Bacillus
megaterium) 		4 / 6 GLY A  94
TYR A 158
GLU A  96
ASN A 116
 None
 1.08A 3e9rA-3autA:
3.0		 3e9rA-3autA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3aut GLUCOSE
1-DEHYDROGENASE 4
(Bacillus
megaterium) 		5 / 12 GLY A 123
ASN A 142
VAL A  73
ALA A  79
LEU A  86
 None
 1.17A 3p2kB-3autA:
5.0		 3p2kB-3autA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3aut GLUCOSE
1-DEHYDROGENASE 4
(Bacillus
megaterium) 		5 / 10 ALA A 159
TYR A 158
GLY A 187
SER A 161
GLY A 163
 None
 1.33A 4mmdA-3autA:
undetectable		 4mmdA-3autA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3aut GLUCOSE
1-DEHYDROGENASE 4
(Bacillus
megaterium) 		4 / 6 PHE A  27
VAL A  10
MET A 143
ILE A 141
 None
 1.26A 5iwuA-3autA:
undetectable		 5iwuA-3autA:
22.46