SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3auz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  45
HIS A 128
LEU A 155
ILE A 154
PHE A 143
 None
 1.34A 1fmlA-3auzA:
undetectable		 1fmlA-3auzA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  48
SER A  47
ILE A 106
LEU A 107
HIS A 128
 None
None
GOL  A 411 (-4.5A)
None
None
 1.25A 1kyvA-3auzA:
undetectable
1kyvE-3auzA:
undetectable		 1kyvA-3auzA:
18.94
1kyvE-3auzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MN  A 402 ( 2.9A)
None
MN  A 401 (-3.4A)
 0.49A 1oe1A-3auzA:
undetectable		 1oe1A-3auzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MN  A 402 ( 2.9A)
None
MN  A 401 (-3.4A)
 0.49A 1oe3A-3auzA:
undetectable		 1oe3A-3auzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 191
HIS A  10
HIS A 188
ASP A  49
GLY A  48
 None
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 402 ( 2.9A)
None
 1.24A 1zz1A-3auzA:
undetectable		 1zz1A-3auzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A  10
ASP A  49
HIS A 188
ASP A   8
 MN  A 401 (-3.4A)
MN  A 402 ( 2.9A)
MN  A 401 (-3.5A)
MN  A 401 (-3.3A)
 0.92A 2xadC-3auzA:
undetectable		 2xadC-3auzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MN  A 402 ( 2.9A)
None
MN  A 401 (-3.4A)
 0.49A 2xxgA-3auzA:
undetectable		 2xxgA-3auzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		3 / 3 ASP A  49
HIS A  85
HIS A  10
 MN  A 402 ( 2.9A)
None
MN  A 401 (-3.4A)
 0.50A 2xxgC-3auzA:
undetectable		 2xxgC-3auzA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		6 / 12 TYR A 225
SER A  47
ILE A 239
ASP A 238
LEU A 234
LEU A 155
 None
 1.48A 3lcvB-3auzA:
undetectable		 3lcvB-3auzA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A   8
ALA A   7
SER A  47
TYR A 202
 MN  A 401 (-3.3A)
None
None
None
 1.10A 3rodA-3auzA:
undetectable		 3rodA-3auzA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 11 LEU A 100
VAL A  44
LEU A  71
LEU A  50
ALA A  64
 None
 1.06A 4p65B-3auzA:
undetectable
4p65D-3auzA:
undetectable
4p65G-3auzA:
undetectable
4p65H-3auzA:
undetectable		 4p65B-3auzA:
7.07
4p65D-3auzA:
7.07
4p65G-3auzA:
4.82
4p65H-3auzA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE401_0
(PROTON-GATED ION
CHANNEL)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 5 ARG A  21
GLU A 207
PHE A 249
ARG A 247
 None
 1.37A 4zzcA-3auzA:
0.0
4zzcE-3auzA:
0.0		 4zzcA-3auzA:
23.16
4zzcE-3auzA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 6 ASP A  49
ASP A   8
HIS A  10
HIS A 188
HIS A 158
 MN  A 402 ( 2.9A)
MN  A 401 (-3.3A)
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 402 (-3.5A)
 0.98A 5ncdA-3auzA:
undetectable
5ncdD-3auzA:
2.3		 5ncdA-3auzA:
19.10
5ncdD-3auzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
HIS A  85
HIS A  10
HIS A 186
 MN  A 402 ( 2.9A)
None
MN  A 401 (-3.4A)
MN  A 402 (-3.3A)
 0.92A 5ncdA-3auzA:
undetectable
5ncdD-3auzA:
2.3		 5ncdA-3auzA:
19.10
5ncdD-3auzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		5 / 6 ASP A  49
ASP A   8
HIS A  10
HIS A 188
HIS A 158
 MN  A 402 ( 2.9A)
MN  A 401 (-3.3A)
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 402 (-3.5A)
 0.97A 5ncdB-3auzA:
undetectable
5ncdC-3auzA:
undetectable		 5ncdB-3auzA:
19.10
5ncdC-3auzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
HIS A  85
HIS A  10
HIS A 186
 MN  A 402 ( 2.9A)
None
MN  A 401 (-3.4A)
MN  A 402 (-3.3A)
 0.91A 5ncdB-3auzA:
undetectable
5ncdC-3auzA:
undetectable		 5ncdB-3auzA:
19.10
5ncdC-3auzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A  49
ASP A   8
HIS A  10
HIS A 188
 MN  A 402 ( 2.9A)
MN  A 401 (-3.3A)
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
 0.95A 5nekB-3auzA:
2.1		 5nekB-3auzA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
ASP A   8
HIS A  10
HIS A 188
 MN  A 402 ( 2.9A)
MN  A 401 (-3.3A)
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
 0.82A 5nelA-3auzA:
2.2
5nelD-3auzA:
undetectable		 5nelA-3auzA:
19.10
5nelD-3auzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
HIS A  10
HIS A 188
HIS A 158
 MN  A 402 ( 2.9A)
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 402 (-3.5A)
 0.89A 5nelA-3auzA:
2.2
5nelD-3auzA:
undetectable		 5nelA-3auzA:
19.10
5nelD-3auzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3auz DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
MRE11
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  49
HIS A  10
HIS A 188
HIS A 158
 MN  A 402 ( 2.9A)
MN  A 401 (-3.4A)
MN  A 401 (-3.5A)
MN  A 402 (-3.5A)
 0.87A 5nelB-3auzA:
undetectable
5nelC-3auzA:
undetectable		 5nelB-3auzA:
19.10
5nelC-3auzA:
19.10