SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3av6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 9 LEU A 598
ASN A 696
VAL A 658
GLY A 657
CYH A 662
None
None
None
None
ZN  A2002 (-2.1A)
1.27A 1e7aA-3av6A:
undetectable
1e7aA-3av6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 PHE A1567
TYR A1565
GLY A1152
GLY A1153
None
None
SAM  A   1 (-4.1A)
SAM  A   1 (-3.6A)
0.49A 1ekjE-3av6A:
2.1
1ekjF-3av6A:
2.3
1ekjE-3av6A:
10.57
1ekjF-3av6A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A1267
PHE A1158
VAL A1582
LEU A1586
None
None
SAM  A   1 (-3.8A)
None
0.95A 1fiqC-3av6A:
undetectable
1fiqC-3av6A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A1319
ARG A 879
LEU A1302
SER A1355
None
1.06A 1hk3A-3av6A:
2.5
1hk3A-3av6A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 8 PHE A1148
GLU A1171
ASP A1193
PRO A1227
LEU A1250
SAM  A   1 (-4.9A)
SAM  A   1 (-2.6A)
SAM  A   1 (-3.6A)
None
SAM  A   1 (-4.6A)
1.42A 1hmyA-3av6A:
16.7
1hmyA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 8 PHE A1148
GLU A1171
ASP A1193
PRO A1228
LEU A1250
SAM  A   1 (-4.9A)
SAM  A   1 (-2.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
0.63A 1hmyA-3av6A:
16.7
1hmyA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 6 HIS A1509
LEU A1515
LEU A1502
PRO A1503
None
1.17A 1hz4A-3av6A:
undetectable
1hz4A-3av6A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
CYH A1194
PRO A1228
PHE A1148
GLY A1150
SAM  A   1 (-3.6A)
SAM  A   1 (-3.5A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
0.66A 1nw5A-3av6A:
4.8
1nw5A-3av6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 CYH A 656
ARG A 654
CYH A 694
ZN  A2002 (-2.4A)
None
ZN  A2002 (-2.5A)
1.42A 1p9gA-3av6A:
undetectable
1p9gA-3av6A:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 GLY A1523
THR A1367
GLY A1305
THR A1312
ALA A1338
None
0.96A 1utdL-3av6A:
undetectable
1utdM-3av6A:
undetectable
1utdL-3av6A:
4.82
1utdM-3av6A:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 SER A1421
VAL A1453
LEU A1449
None
0.72A 1yajG-3av6A:
undetectable
1yajG-3av6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LYS A 726
TYR A 778
PRO A 776
LEU A 777
None
0.98A 1z2bB-3av6A:
undetectable
1z2bB-3av6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 LEU A 598
ASN A 696
VAL A 658
GLY A 657
CYH A 662
None
None
None
None
ZN  A2002 (-2.1A)
1.33A 2bxeA-3av6A:
undetectable
2bxeA-3av6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 PHE A1148
GLY A1150
GLY A1152
ASP A1193
PRO A1228
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-4.1A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
1.02A 2dpmA-3av6A:
5.4
2dpmA-3av6A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 THR A 540
PRO A 543
TYR A 513
None
0.95A 2dxrA-3av6A:
undetectable
2dxrA-3av6A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
7 / 12 PHE A1148
GLY A1150
GLY A1153
ASP A1193
PRO A1228
LEU A1250
TYR A1565
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
None
1.40A 2hmyB-3av6A:
16.5
2hmyB-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
7 / 12 PHE A1148
GLY A1150
GLY A1153
ASP A1193
PRO A1228
LEU A1250
VAL A1582
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
SAM  A   1 (-3.8A)
0.96A 2hmyB-3av6A:
16.5
2hmyB-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ALA A1581
GLN A1559
LEU A1586
THR A1166
PHE A1180
SAM  A   1 (-3.7A)
None
None
None
None
1.37A 2oaxF-3av6A:
undetectable
2oaxF-3av6A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 PHE A1274
PHE A1232
PHE A1246
None
0.84A 2od9A-3av6A:
1.6
2od9A-3av6A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 LEU A1302
VAL A1309
GLN A1311
ILE A1590
LEU A1154
None
None
None
None
SAM  A   1 (-4.7A)
1.16A 2q6hA-3av6A:
undetectable
2q6hA-3av6A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 LEU A1302
VAL A1309
GLN A1311
ILE A1590
LEU A1154
None
None
None
None
SAM  A   1 (-4.7A)
1.17A 2q72A-3av6A:
undetectable
2q72A-3av6A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 LEU A1442
PRO A1443
LEU A1497
None
0.41A 2qd5B-3av6A:
undetectable
2qd5B-3av6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 ASN A 549
ARG A 550
ASP A1419
None
0.98A 2qe6B-3av6A:
5.8
2qe6B-3av6A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 LEU A1302
VAL A1309
GLN A1311
ILE A1590
LEU A1154
None
None
None
None
SAM  A   1 (-4.7A)
1.15A 2qeiA-3av6A:
undetectable
2qeiA-3av6A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 PHE A1274
PHE A1232
PHE A1246
None
0.84A 2qqgA-3av6A:
1.6
2qqgA-3av6A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 7 GLY A1226
CYH A1229
PHE A1232
PHE A1246
SAM  A   1 (-4.4A)
None
None
None
1.15A 2qx4A-3av6A:
3.1
2qx4B-3av6A:
2.7
2qx4A-3av6A:
10.64
2qx4B-3av6A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 9 ILE A 512
PHE A 475
VAL A 481
GLU A 479
None
0.83A 2vufA-3av6A:
undetectable
2vufA-3av6A:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
12 / 12 PHE A1148
GLY A1150
GLY A1153
LEU A1154
MET A1172
TRP A1173
CYH A1194
PRO A1228
LEU A1250
ASN A1580
ALA A1581
VAL A1582
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-3.6A)
SAM  A   1 (-4.7A)
SAM  A   1 (-3.6A)
None
SAM  A   1 (-3.5A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
SAM  A   1 (-4.5A)
SAM  A   1 (-3.7A)
SAM  A   1 (-3.8A)
0.00A 3av6A-3av6A:
62.4
3av6A-3av6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
7 / 12 PHE A1148
GLY A1152
LEU A1154
PRO A1228
LEU A1250
ASN A1580
ALA A1581
SAM  A   1 (-4.9A)
SAM  A   1 (-4.1A)
SAM  A   1 (-4.7A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
SAM  A   1 (-4.5A)
SAM  A   1 (-3.7A)
1.04A 3av6A-3av6A:
62.4
3av6A-3av6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_B_CUB1022_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 CYH A 823
CYH A 897
HIS A 798
ZN  A2004 (-2.2A)
ZN  A2004 (-2.2A)
None
0.85A 3dtuB-3av6A:
undetectable
3dtuB-3av6A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_D_CUD3_0
(CYTOCHROME C OXIDASE
SUBUNIT 2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 CYH A 823
CYH A 897
HIS A 798
ZN  A2004 (-2.2A)
ZN  A2004 (-2.2A)
None
0.86A 3dtuD-3av6A:
undetectable
3dtuD-3av6A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 PHE A1148
GLY A1152
PRO A1228
LEU A1250
ASN A1580
SAM  A   1 (-4.9A)
SAM  A   1 (-4.1A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
SAM  A   1 (-4.5A)
1.01A 3eeoA-3av6A:
18.0
3eeoA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
6 / 12 PHE A1148
GLY A1153
ASP A1193
PRO A1228
LEU A1250
ASN A1580
SAM  A   1 (-4.9A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
SAM  A   1 (-4.5A)
0.75A 3eeoA-3av6A:
18.0
3eeoA-3av6A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 ASP A1563
GLN A1559
PRO A1583
GLN A1160
None
1.08A 3oyaA-3av6A:
2.4
3oyaA-3av6A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 ARG A1262
GLN A 870
PHE A 880
PRO A 842
GLU A 849
None
1.30A 3qelA-3av6A:
undetectable
3qelB-3av6A:
2.2
3qelA-3av6A:
14.25
3qelB-3av6A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 7 GLN A 374
HIS A 376
GLU A 383
PRO A 466
None
1.39A 3ql6A-3av6A:
undetectable
3ql6A-3av6A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 PHE A 631
ALA A 621
ASN A1248
PHE A1246
None
1.05A 3t3sE-3av6A:
undetectable
3t3sE-3av6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
0.98A 3v81A-3av6A:
undetectable
3v81A-3av6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
1.02A 3v81C-3av6A:
undetectable
3v81C-3av6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ALA A1581
GLN A1559
LEU A1586
THR A1166
PHE A1180
SAM  A   1 (-3.7A)
None
None
None
None
1.43A 3vhuA-3av6A:
undetectable
3vhuA-3av6A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 6 GLY A1150
GLU A1171
ASP A1193
ASP A1146
SAM  A   1 ( 3.9A)
SAM  A   1 (-2.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.7A)
0.87A 3vywC-3av6A:
6.7
3vywC-3av6A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ILE A 504
VAL A 563
ILE A 483
VAL A 481
LEU A 472
None
1.13A 3w67B-3av6A:
undetectable
3w67B-3av6A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 GLY A1152
GLY A1153
ASP A1193
PRO A1228
LEU A1250
SAM  A   1 (-4.1A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
0.81A 4fp9D-3av6A:
7.3
4fp9D-3av6A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 GLY A1152
GLY A1153
ASP A1193
PRO A1228
LEU A1250
SAM  A   1 (-4.1A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.6A)
0.85A 4fzvA-3av6A:
7.2
4fzvA-3av6A:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 5 PHE A 634
THR A1242
PHE A1246
ILE A 639
None
1.09A 4jx1E-3av6A:
undetectable
4jx1E-3av6A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 LEU A1268
MET A1172
GLU A1171
ILE A1170
ALA A1169
None
SAM  A   1 (-3.6A)
SAM  A   1 (-2.6A)
None
None
0.97A 4ltwA-3av6A:
undetectable
4ltwA-3av6A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 ILE A1416
VAL A1550
VAL A1552
ARG A1574
None
1.19A 4m6tA-3av6A:
undetectable
4m6tA-3av6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 ILE A1571
VAL A1550
VAL A1552
ARG A1574
None
1.10A 4m6tA-3av6A:
undetectable
4m6tA-3av6A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 7 HIS A1105
PRO A1103
PHE A1024
ASP A1049
None
1.31A 4odjA-3av6A:
undetectable
4odjA-3av6A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 10 ARG A1262
GLN A 870
PHE A 880
PRO A 842
GLU A 849
None
1.42A 4pe5A-3av6A:
1.2
4pe5B-3av6A:
1.6
4pe5A-3av6A:
20.03
4pe5B-3av6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 10 ARG A1262
GLN A 870
PHE A 880
PRO A 842
GLU A 849
None
1.30A 4pe5C-3av6A:
undetectable
4pe5D-3av6A:
1.8
4pe5C-3av6A:
20.03
4pe5D-3av6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
1.03A 4puoC-3av6A:
undetectable
4puoC-3av6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
1.02A 4pwdA-3av6A:
undetectable
4pwdA-3av6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
0.90A 4q0bA-3av6A:
undetectable
4q0bA-3av6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 ARG A1440
ASP A1438
TRP A1439
None
1.11A 4xdqA-3av6A:
undetectable
4xdqA-3av6A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 5 PHE A1232
PHE A 631
PHE A1246
VAL A1251
None
1.21A 5a1rA-3av6A:
undetectable
5a1rA-3av6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 ARG A1262
GLN A 870
PHE A 880
PRO A 842
GLU A 849
None
1.29A 5ewjA-3av6A:
undetectable
5ewjB-3av6A:
2.1
5ewjA-3av6A:
14.62
5ewjB-3av6A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ARG A1262
GLN A 870
PHE A 880
PRO A 842
GLU A 849
None
1.30A 5ewjC-3av6A:
undetectable
5ewjD-3av6A:
2.0
5ewjC-3av6A:
14.62
5ewjD-3av6A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 ASP A1522
SER A1037
TYR A1038
None
0.76A 5glmA-3av6A:
0.2
5glmA-3av6A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 PRO A 883
LEU A 819
VAL A 837
TYR A 839
LEU A 898
None
1.32A 5hbmA-3av6A:
undetectable
5hbmA-3av6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-2.6A)
0.59A 5hfjA-3av6A:
undetectable
5hfjA-3av6A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-2.6A)
0.52A 5hfjD-3av6A:
undetectable
5hfjD-3av6A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 ASP A1193
PRO A1228
PHE A1148
GLY A1150
GLU A1171
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-2.6A)
0.56A 5hfjF-3av6A:
5.5
5hfjF-3av6A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 11 PHE A1148
GLY A1150
GLU A1171
ASP A1193
PRO A1228
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-2.6A)
SAM  A   1 (-3.6A)
SAM  A   1 ( 4.2A)
0.75A 5hjiA-3av6A:
8.0
5hjiA-3av6A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 GLY A 657
CYH A 662
CYH A 659
None
ZN  A2002 (-2.1A)
ZN  A2002 (-2.3A)
0.92A 5inzB-3av6A:
undetectable
5inzB-3av6A:
1.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 10 GLY A 478
ILE A 512
GLN A 566
LEU A 472
LEU A 482
None
1.03A 5l0zB-3av6A:
undetectable
5l0zB-3av6A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 ALA A 603
PHE A 485
ILE A 433
VAL A 428
None
0.82A 5nujA-3av6A:
undetectable
5nujA-3av6A:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 GLY A 474
MET A 508
VAL A 428
GLY A 484
ILE A 483
None
1.13A 5vooD-3av6A:
undetectable
5vooD-3av6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
5 / 12 GLY A 474
MET A 508
VAL A 428
GLY A 484
ILE A 483
None
1.12A 5vooE-3av6A:
undetectable
5vooE-3av6A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 8 ASP A 788
GLU A 787
GLN A 792
LEU A 828
None
0.90A 5w3jB-3av6A:
undetectable
5w3jB-3av6A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 ASP A1070
PHE A1088
ARG A 999
None
0.90A 5yw0A-3av6A:
undetectable
5yw0A-3av6A:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB604_0
(AMINE OXIDASE LKCE)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
4 / 4 HIS A1105
PRO A1103
ALA A1106
ARG A 999
None
1.48A 6f32B-3av6A:
2.7
6f32B-3av6A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
3 / 3 HIS A1415
ARG A1548
ILE A1380
None
0.70A 6fgdA-3av6A:
2.4
6fgdA-3av6A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus
musculus)
6 / 12 PHE A1148
GLY A1150
GLY A1153
ASP A1193
ASN A1580
VAL A1582
SAM  A   1 (-4.9A)
SAM  A   1 ( 3.9A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.6A)
SAM  A   1 (-4.5A)
SAM  A   1 (-3.8A)
0.87A 6mhtA-3av6A:
16.2
6mhtA-3av6A:
13.47