SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3avs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		3 / 4 VAL A1168
TRP A1194
TRP A1166
 None
 1.35A 1gmkA-3avsA:
undetectable
1gmkB-3avsA:
undetectable		 1gmkA-3avsA:
3.33
1gmkB-3avsA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 6 LEU A 956
PRO A1107
LEU A 977
ALA A 976
 None
 0.81A 2vcvB-3avsA:
undetectable		 2vcvB-3avsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 6 LEU A 956
PRO A1107
LEU A 977
ALA A 976
 None
 0.90A 2vcvK-3avsA:
0.4		 2vcvK-3avsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 8 LEU A 956
PRO A1107
LEU A 977
ALA A 976
 None
 0.80A 2vcvP-3avsA:
undetectable		 2vcvP-3avsA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		5 / 9 ILE A1157
ILE A1159
GLU A1102
LEU A1103
LYS A1105
 None
EDO  A1513 (-4.5A)
None
None
None
 1.24A 3f78A-3avsA:
undetectable		 3f78A-3avsA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		5 / 9 ILE A1157
ILE A1159
GLU A1102
LEU A1103
LYS A1105
 None
EDO  A1513 (-4.5A)
None
None
None
 1.31A 3f78B-3avsA:
undetectable		 3f78B-3avsA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 6 ARG A1142
PHE A1079
ASP A1013
PRO A1007
 None
 0.96A 3jqaA-3avsA:
undetectable		 3jqaA-3avsA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 6 ARG A1142
PHE A1079
ASP A1013
PRO A1007
 None
 0.96A 3jqaC-3avsA:
undetectable		 3jqaC-3avsA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 6 ARG A1142
PHE A1079
ASP A1013
PRO A1007
 None
 0.95A 3jqaD-3avsA:
undetectable		 3jqaD-3avsA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		3 / 3 HIS A1226
TRP A1194
SER A1154
 NI  A1503 ( 3.4A)
None
OGA  A1501 (-2.7A)
 1.17A 4lrhD-3avsA:
undetectable		 4lrhD-3avsA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		5 / 12 GLU A1202
VAL A1176
LEU A1200
VAL A1169
PRO A1170
 None
 1.16A 4xiwB-3avsA:
undetectable
4xiwE-3avsA:
undetectable		 4xiwB-3avsA:
18.92
4xiwE-3avsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 7 GLN A1133
GLY A1128
VAL A1268
SER A1154
 None
None
None
OGA  A1501 (-2.7A)
 0.80A 6hu9S-3avsA:
undetectable
6hu9q-3avsA:
undetectable		 6hu9S-3avsA:
10.12
6hu9q-3avsA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 6 TYR A1330
GLU A1337
CYH A1295
GLU A1257
 None
None
EDO  A1508 (-2.3A)
EDO  A1508 (-2.9A)
 1.44A 6mn5A-3avsA:
undetectable		 6mn5A-3avsA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3avs LYSINE-SPECIFIC
DEMETHYLASE 6A
(Homo
sapiens) 		4 / 6 THR A1245
LEU A1244
MET A1291
LEU A1119
 None
None
EDO  A1512 ( 3.2A)
None
 0.86A 6mvxA-3avsA:
undetectable
6mvxB-3avsA:
undetectable
6mvxC-3avsA:
undetectable		 6mvxA-3avsA:
20.63
6mvxB-3avsA:
20.63
6mvxC-3avsA:
20.63