SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3awd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 4 ILE A  39
MET A  66
VAL A 130
GLY A  18
 None
 1.31A 1e06B-3awdA:
undetectable		 1e06B-3awdA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 ASP A  41
ASP A  67
ILE A 118
ILE A  97
THR A  69
 None
 1.31A 1kijA-3awdA:
undetectable		 1kijA-3awdA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 162
ILE A  22
GLY A 146
ALA A 167
SER A 165
 None
 1.20A 1nbhA-3awdA:
8.1		 1nbhA-3awdA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 162
ILE A  22
GLY A 146
ALA A 167
SER A 165
 None
 1.21A 1nbhC-3awdA:
6.4		 1nbhC-3awdA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 162
ILE A  22
GLY A 146
ALA A 167
SER A 165
 None
 1.21A 1nbhD-3awdA:
6.9		 1nbhD-3awdA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 162
ILE A  22
GLY A 146
ALA A 167
SER A 165
 None
 1.16A 1nbiA-3awdA:
8.2		 1nbiA-3awdA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 TYR A 162
ILE A  22
GLY A 146
ALA A 167
SER A 165
 None
 1.15A 1nbiB-3awdA:
8.2		 1nbiB-3awdA:
24.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		7 / 11 GLY A  17
ALA A  19
ASP A  41
LEU A  42
ASP A  67
VAL A  68
ALA A  95
 None
 0.67A 1uayA-3awdA:
30.3		 1uayA-3awdA:
32.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		7 / 10 GLY A  17
ALA A  19
ASP A  41
LEU A  42
ASP A  67
VAL A  68
ALA A  95
 None
 0.72A 1uayB-3awdA:
30.7		 1uayB-3awdA:
32.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 4 VAL A  74
LEU A 135
ILE A 185
LEU A 176
 None
 0.82A 2byoA-3awdA:
undetectable		 2byoA-3awdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 GLY A  17
ALA A  19
LEU A  42
VAL A  68
THR A  69
 None
 0.98A 2nyuB-3awdA:
4.1		 2nyuB-3awdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 4 GLY A 146
VAL A 190
GLY A 245
THR A 244
 None
 0.93A 3ib2A-3awdA:
undetectable		 3ib2A-3awdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ILE A 152
THR A 255
HIS A 170
TYR A 162
 None
 1.16A 4qwpA-3awdA:
0.9		 4qwpA-3awdA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ASP A   9
ARG A   7
GLU A   4
ARG A  11
 None
 1.49A 4qyqC-3awdA:
undetectable		 4qyqC-3awdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 12 LEU A  42
ASP A  41
GLY A  17
ALA A  95
ILE A  97
 None
 0.93A 4xdrA-3awdA:
undetectable		 4xdrA-3awdA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 5 ALA A  93
THR A  16
VAL A  78
ILE A  14
 None
 0.96A 4xe3B-3awdA:
undetectable		 4xe3B-3awdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 ASP A   9
ARG A   7
GLU A   4
ARG A  11
 None
 1.49A 5hpwC-3awdA:
undetectable		 5hpwC-3awdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		4 / 6 SER A 165
GLY A 122
ASN A 121
ILE A  97
 None
 1.16A 5j4nA-3awdA:
undetectable		 5j4nA-3awdA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 11 GLY A 146
ALA A 191
ALA A 189
ILE A 173
VAL A 169
 None
 0.98A 5yk2A-3awdA:
undetectable		 5yk2A-3awdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 VAL A  51
LEU A  54
GLY A  23
LEU A  24
GLN A  20
 None
 1.13A 6czmA-3awdA:
undetectable
6czmB-3awdA:
undetectable		 6czmA-3awdA:
23.70
6czmB-3awdA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3awd PUTATIVE POLYOL
DEHYDROGENASE
(Gluconobacter
oxydans) 		5 / 9 VAL A  51
LEU A  54
GLY A  23
LEU A  24
GLN A  20
 None
 1.19A 6czmB-3awdA:
undetectable
6czmC-3awdA:
undetectable		 6czmB-3awdA:
23.70
6czmC-3awdA:
23.70