SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3awk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 5 HIS A 313
SER A 201
LEU A 115
GLY A 226
 None
 0.89A 1a4lB-3awkA:
undetectable		 1a4lB-3awkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 LEU A 197
GLY A 228
ASN A  36
ALA A 199
LEU A 154
 None
 1.01A 1bx4A-3awkA:
undetectable		 1bx4A-3awkA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 11 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.07A 1dhiB-3awkA:
undetectable		 1dhiB-3awkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.07A 1draB-3awkA:
undetectable		 1draB-3awkA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 9 ALA A 184
GLY A 235
ALA A  27
LEU A 394
LEU A 181
 None
 1.12A 1nr6A-3awkA:
undetectable		 1nr6A-3awkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 10 LEU A 181
LEU A  30
VAL A 196
GLY A 235
ALA A 188
 None
 1.11A 1pxxA-3awkA:
undetectable		 1pxxA-3awkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 9 LEU A 181
LEU A  30
VAL A 196
GLY A 235
ALA A 188
 None
 1.11A 1pxxB-3awkA:
undetectable		 1pxxB-3awkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 LEU A 181
LEU A  30
VAL A 196
GLY A 235
ALA A 188
 None
 1.10A 1pxxC-3awkA:
undetectable		 1pxxC-3awkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 10 LEU A 181
LEU A  30
VAL A 196
GLY A 235
ALA A 188
 None
 1.11A 1pxxD-3awkA:
undetectable		 1pxxD-3awkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.08A 1ra3A-3awkA:
undetectable		 1ra3A-3awkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 10 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.07A 1rb3A-3awkA:
undetectable		 1rb3A-3awkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.11A 1re7A-3awkA:
undetectable		 1re7A-3awkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 381
GLY A 315
ALA A 318
VAL A 352
SER A 351
 None
GOL  A 500 ( 3.9A)
None
None
None
 1.17A 1sg9C-3awkA:
undetectable		 1sg9C-3awkA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 LEU A 154
ALA A 123
LEU A 232
LEU A 197
VAL A 196
 None
 1.15A 2c12C-3awkA:
undetectable		 2c12C-3awkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 7 THR A 391
LEU A 257
VAL A 292
VAL A 312
 None
 1.03A 2cppA-3awkA:
undetectable		 2cppA-3awkA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 319
HIS A 313
PHE A 225
GLY A 226
LEU A 353
 None
None
GOL  A 501 (-4.3A)
None
None
 0.86A 2nyrB-3awkA:
undetectable		 2nyrB-3awkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 11 ILE A 233
ALA A 120
LEU A 154
LEU A 160
ILE A 134
 None
 1.05A 2w9sA-3awkA:
undetectable		 2w9sA-3awkA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 8 ILE A 233
ALA A 120
LEU A 154
ILE A 134
 None
 0.68A 2w9sE-3awkA:
undetectable		 2w9sE-3awkA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A  32
GLY A 372
THR A 371
ASN A 306
LEU A 329
 None
 1.03A 2y7hB-3awkA:
undetectable		 2y7hB-3awkA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 6 THR A 179
VAL A 180
GLU A 202
CYH A 200
 None
 1.12A 3b6rB-3awkA:
undetectable		 3b6rB-3awkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 VAL A 355
GLU A 373
GLY A 372
ILE A 397
ARG A 395
 None
 1.41A 3bwyA-3awkA:
undetectable		 3bwyA-3awkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ALA A 229
GLY A 228
LEU A 353
SER A 351
MET A 347
 None
 1.35A 3bxoA-3awkA:
undetectable		 3bxoA-3awkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ALA A 229
LEU A 353
SER A 351
MET A 347
SER A  35
 None
 1.47A 3bxoB-3awkA:
undetectable		 3bxoB-3awkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.08A 3drcB-3awkA:
undetectable		 3drcB-3awkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 10 ALA A 176
LEU A 353
VAL A 352
ILE A 249
LEU A 394
 None
 1.12A 3jw5B-3awkA:
undetectable		 3jw5B-3awkA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 5 TYR A  46
ILE A 107
LEU A  82
PHE A  80
 None
 1.22A 3ls4L-3awkA:
undetectable		 3ls4L-3awkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 5 ASP A 321
LEU A 320
ILE A 285
PRO A 282
 None
 1.20A 3s3vA-3awkA:
undetectable		 3s3vA-3awkA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 5 SER A 396
THR A 370
GLU A 248
ASP A 237
 None
 0.92A 3tm4A-3awkA:
undetectable		 3tm4A-3awkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 5 SER A 396
THR A 370
GLU A 248
ASP A 237
 None
 0.93A 3tm4B-3awkA:
undetectable		 3tm4B-3awkA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.11A 4ptjA-3awkA:
undetectable		 4ptjA-3awkA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 ILE A 121
ALA A 119
LEU A 154
ILE A 134
ILE A 124
 None
 1.03A 4x5gB-3awkA:
undetectable		 4x5gB-3awkA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 LEU A 356
VAL A 352
LEU A 293
ILE A 381
LEU A 329
 None
 1.14A 4y0qA-3awkA:
undetectable		 4y0qA-3awkA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 VAL A 355
GLU A 373
GLY A 372
ILE A 397
ARG A 395
 None
 1.37A 5lsaA-3awkA:
undetectable		 5lsaA-3awkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 8 ILE A  93
ARG A 104
GLN A 105
VAL A 203
 None
 1.15A 5vlmF-3awkA:
undetectable		 5vlmF-3awkA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		5 / 12 GLY A 177
VAL A 281
LEU A 277
GLY A 315
ASN A 346
 None
None
GOL  A 500 (-4.2A)
GOL  A 500 ( 3.9A)
None
 1.07A 5vopA-3awkA:
undetectable		 5vopA-3awkA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		4 / 7 PHE A 383
GLY A 384
GLY A 386
THR A 142
 None
GOL  A 500 ( 4.2A)
None
GOL  A 501 ( 4.7A)
 0.76A 5ybbB-3awkA:
undetectable		 5ybbB-3awkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE
(Huperzia
serrata) 		3 / 3 GLU A 189
ASP A 237
PRO A 238
 None
 0.30A 6berA-3awkA:
undetectable		 6berA-3awkA:
3.86