SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ax6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 8 GLU A 197
LEU A 358
ALA A 361
LEU A 362
 None
 0.80A 1hwiD-3ax6A:
2.7		 1hwiD-3ax6A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A  18
GLY A  13
ILE A 282
GLY A   5
ILE A  28
 None
 0.85A 2hs1B-3ax6A:
undetectable		 2hs1B-3ax6A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 7 GLY A 266
MET A 181
GLY A 345
PHE A 278
 None
 0.95A 2qwxA-3ax6A:
3.4
2qwxB-3ax6A:
3.4		 2qwxA-3ax6A:
19.90
2qwxB-3ax6A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A  18
GLY A  13
ILE A 282
GLY A   5
ILE A  28
 None
 0.93A 2rkgB-3ax6A:
undetectable		 2rkgB-3ax6A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		3 / 3 LYS A 122
ARG A 140
LYS A 110
 None
 1.42A 3okxA-3ax6A:
undetectable		 3okxA-3ax6A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		3 / 3 HIS A 267
HIS A 331
ILE A 270
 None
 0.80A 3u52A-3ax6A:
undetectable
3u52C-3ax6A:
undetectable		 3u52A-3ax6A:
19.25
3u52C-3ax6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A  18
GLY A  13
ILE A 282
GLY A   5
ILE A  28
 None
 0.94A 3ucbB-3ax6A:
undetectable		 3ucbB-3ax6A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 6 LEU A  81
LEU A  78
ILE A  73
THR A  66
 None
 0.95A 4do3B-3ax6A:
undetectable		 4do3B-3ax6A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 8 GLY A 188
GLY A 237
GLU A 233
VAL A 182
 None
 0.93A 4fgzA-3ax6A:
3.6		 4fgzA-3ax6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A 108
ILE A  98
ILE A 113
ALA A 234
ILE A 243
 None
 0.80A 4rp8C-3ax6A:
undetectable		 4rp8C-3ax6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 5 ILE A 240
PRO A 262
HIS A 346
VAL A 196
 None
 1.33A 4s0vA-3ax6A:
3.1		 4s0vA-3ax6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 6 GLY A  13
ASP A  69
GLY A  39
SER A  63
 None
 0.97A 4z53A-3ax6A:
2.4
4z53B-3ax6A:
2.8		 4z53A-3ax6A:
19.47
4z53B-3ax6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 6 TYR A 193
GLY A 291
GLU A 279
ARG A 283
 None
 1.36A 4zbqA-3ax6A:
undetectable		 4zbqA-3ax6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A  18
GLY A  13
ILE A 282
GLY A   5
ILE A  28
 None
 0.84A 5e5jB-3ax6A:
undetectable		 5e5jB-3ax6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A  18
GLY A  13
ILE A 282
GLY A   5
ILE A  28
 None
 0.86A 5e5kB-3ax6A:
undetectable		 5e5kB-3ax6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A  59
GLY A  49
ALA A  48
ILE A  28
ILE A  46
 None
 0.90A 5e5kB-3ax6A:
undetectable		 5e5kB-3ax6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 7 GLY A  13
THR A  17
ILE A  28
VAL A  27
 None
 0.75A 5ik1A-3ax6A:
undetectable		 5ik1A-3ax6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 GLY A  39
ILE A   4
ASP A  69
LEU A  18
ALA A  20
 None
 0.98A 5l0zA-3ax6A:
2.3		 5l0zA-3ax6A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		5 / 12 LEU A  18
GLY A  13
ILE A 282
GLY A   5
ILE A  28
 None
 0.84A 5t8hB-3ax6A:
undetectable		 5t8hB-3ax6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 6 ILE A 240
ILE A   7
HIS A  89
PHE A  51
 None
 1.10A 5vkqA-3ax6A:
undetectable
5vkqB-3ax6A:
undetectable		 5vkqA-3ax6A:
11.99
5vkqB-3ax6A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Thermotoga
maritima) 		4 / 6 GLU A 257
PHE A 246
VAL A 115
PRO A 116
 None
ADP  A 381 (-4.8A)
None
None
 1.37A 6fgdA-3ax6A:
4.3		 6fgdA-3ax6A:
23.55