SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3axi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		6 / 12 TYR A  72
ARG A 213
ASP A 215
HIS A 351
ASP A 352
ARG A 446
 GLC  A 601 (-3.7A)
GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 ( 4.7A)
 0.69A 1dedB-3axiA:
24.5		 1dedB-3axiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 375
VAL A 491
GLY A 395
TRP A 581
 None
 1.02A 1jlfA-3axiA:
undetectable
1jlfB-3axiA:
1.1		 1jlfA-3axiA:
22.66
1jlfB-3axiA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		7 / 12 TYR A  72
HIS A 112
PHE A 178
ARG A 213
ASP A 215
HIS A 351
ASP A 352
 GLC  A 601 (-3.7A)
GLC  A 601 (-4.0A)
GLC  A 601 (-3.4A)
GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
 0.98A 1mxdA-3axiA:
20.6		 1mxdA-3axiA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A  62
TYR A  63
VAL A 209
GLY A 211
ILE A  59
 None
 1.13A 1phgA-3axiA:
undetectable		 1phgA-3axiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 437
LEU A 318
ASN A 415
ILE A 419
 None
 0.98A 1yc2E-3axiA:
undetectable		 1yc2E-3axiA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 9 PHE A  62
TYR A  63
VAL A 209
GLY A 211
ILE A  59
 None
 1.18A 2a1oB-3axiA:
undetectable		 2a1oB-3axiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  53
ALA A  54
ASP A  55
ILE A  57
ILE A  49
 None
 1.05A 2b60B-3axiA:
undetectable		 2b60B-3axiA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 330
LEU A 379
ILE A 357
GLY A 372
LEU A 374
 None
 1.21A 2j7xA-3axiA:
undetectable		 2j7xA-3axiA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1305_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 356
ARG A 355
GLY A 391
TRP A 495
 None
 1.46A 2y7kB-3axiA:
undetectable		 2y7kB-3axiA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
 0.76A 3aicA-3axiA:
4.7		 3aicA-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
 0.76A 3aicB-3axiA:
5.6		 3aicB-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		6 / 12 ARG A 213
ASP A 215
ASN A 302
HIS A 351
ASP A  69
TYR A  72
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
None
GLC  A 601 (-3.9A)
GLC  A 601 (-2.6A)
GLC  A 601 (-3.7A)
 0.87A 3aicC-3axiA:
4.6		 3aicC-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		6 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
TYR A  72
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
GLC  A 601 (-3.7A)
 0.73A 3aicC-3axiA:
4.6		 3aicC-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
 0.82A 3aicD-3axiA:
4.7		 3aicD-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
 0.81A 3aicE-3axiA:
4.3		 3aicE-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
 0.77A 3aicF-3axiA:
5.8		 3aicF-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
 0.76A 3aicG-3axiA:
5.3		 3aicG-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 351
ASP A 352
ASP A  69
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
GLC  A 601 (-2.6A)
 0.82A 3aicH-3axiA:
4.8		 3aicH-3axiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 362
SER A 371
SER A 356
GLU A 349
 None
 1.29A 3bc9A-3axiA:
19.3		 3bc9A-3axiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 CYH A 179
PHE A 178
PHE A 159
 None
GLC  A 601 (-3.4A)
GLC  A 601 (-4.6A)
 0.74A 3cr5X-3axiA:
undetectable		 3cr5X-3axiA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 5 PRO A  61
ILE A  59
PRO A  25
TYR A  24
 None
 1.11A 3d9lA-3axiA:
1.7
3d9lY-3axiA:
undetectable		 3d9lA-3axiA:
13.92
3d9lY-3axiA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gB-3axiA:
2.0		 3j6gB-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gD-3axiA:
2.8		 3j6gD-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gF-3axiA:
2.0		 3j6gF-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gH-3axiA:
2.0		 3j6gH-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gJ-3axiA:
2.1		 3j6gJ-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gL-3axiA:
2.0		 3j6gL-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gN-3axiA:
2.9		 3j6gN-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gP-3axiA:
2.8		 3j6gP-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.28A 3j6gR-3axiA:
2.0		 3j6gR-3axiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 100
TRP A 451
PHE A  28
ILE A  42
GLY A  41
ALA A  43
 None
 1.27A 3kk6A-3axiA:
undetectable		 3kk6A-3axiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 100
TRP A 451
PHE A  28
ILE A  42
GLY A  41
 None
 1.22A 3kk6B-3axiA:
undetectable		 3kk6B-3axiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 TRP A 451
PHE A  28
ILE A  42
GLY A  41
ALA A  43
 None
 1.12A 3n8xB-3axiA:
undetectable		 3n8xB-3axiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 409
ASP A  69
GLU A 411
ASP A 215
 None
GLC  A 601 (-2.6A)
None
GLC  A 601 (-2.9A)
 1.14A 4gkhC-3axiA:
3.8
4gkhK-3axiA:
undetectable		 4gkhC-3axiA:
18.84
4gkhK-3axiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 409
ASP A  69
GLU A 411
ASP A 215
 None
GLC  A 601 (-2.6A)
None
GLC  A 601 (-2.9A)
 1.10A 4gkiE-3axiA:
3.6
4gkiG-3axiA:
undetectable		 4gkiE-3axiA:
18.84
4gkiG-3axiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 330
LEU A 379
ILE A 357
GLY A 372
LEU A 374
 None
 1.19A 4j26A-3axiA:
undetectable		 4j26A-3axiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		6 / 12 VAL A 377
LEU A 374
PHE A 559
ALA A 539
SER A 527
LEU A 541
 None
 1.46A 4o1zB-3axiA:
undetectable		 4o1zB-3axiA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 241
ASP A 242
GLN A 279
 None
 0.92A 4oltA-3axiA:
undetectable
4oltB-3axiA:
undetectable		 4oltA-3axiA:
17.85
4oltB-3axiA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 528
LEU A 382
LEU A 541
PHE A 543
 None
 0.77A 4qopC-3axiA:
undetectable		 4qopC-3axiA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 279
SER A 241
ASP A 242
 None
 0.88A 4qwpA-3axiA:
undetectable
4qwpB-3axiA:
undetectable		 4qwpA-3axiA:
16.98
4qwpB-3axiA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  94
VAL A 266
LEU A 205
ILE A 262
 None
 0.78A 4r38A-3axiA:
undetectable		 4r38A-3axiA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 588
ASP A 519
ASP A 555
 None
 0.81A 4uckA-3axiA:
undetectable		 4uckA-3axiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 109
PHE A 178
ARG A 442
 None
GLC  A 601 (-3.4A)
GLC  A 601 (-2.9A)
 0.87A 4xr4B-3axiA:
undetectable		 4xr4B-3axiA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 SER A 180
GLU A 421
GLU A 146
 None
 0.87A 4ymgB-3axiA:
undetectable		 4ymgB-3axiA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 226
PRO A 249
PHE A 254
GLU A 253
 None
 1.28A 5b8iA-3axiA:
undetectable		 5b8iA-3axiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 ARG A 213
ASP A 215
HIS A 305
HIS A 351
ASP A 352
 GLC  A 601 (-3.0A)
GLC  A 601 (-2.9A)
None
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
 0.82A 5csyB-3axiA:
7.7		 5csyB-3axiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 162
GLY A 160
TYR A 174
PHE A 173
 None
 0.99A 5flcB-3axiA:
undetectable		 5flcB-3axiA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 8 SER A 162
GLY A 160
TYR A 174
PHE A 173
 None
 0.99A 5flcF-3axiA:
undetectable		 5flcF-3axiA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  42
ILE A  59
PHE A  62
THR A  97
ILE A  94
 None
 1.17A 5lg3F-3axiA:
0.2		 5lg3F-3axiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.14A 5m54B-3axiA:
undetectable		 5m54B-3axiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 216
HIS A 112
PHE A 159
GLN A  67
ARG A 213
 GLC  A 601 (-4.5A)
GLC  A 601 (-4.0A)
GLC  A 601 (-4.6A)
None
GLC  A 601 (-3.0A)
 1.17A 5m54E-3axiA:
2.4		 5m54E-3axiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 173
ASP A 167
LEU A 185
 None
 0.77A 5uhbC-3axiA:
undetectable		 5uhbC-3axiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 173
ASP A 167
LEU A 185
 None
 0.76A 5uhcC-3axiA:
undetectable		 5uhcC-3axiA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 584
PHE A 501
ILE A 508
THR A 509
 None
 1.13A 5vceA-3axiA:
undetectable		 5vceA-3axiA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  72
HIS A 112
ASP A 215
HIS A 351
ASP A 352
 GLC  A 601 (-3.7A)
GLC  A 601 (-4.0A)
GLC  A 601 (-2.9A)
GLC  A 601 (-3.9A)
GLC  A 601 (-2.8A)
 0.48A 6ag0A-3axiA:
18.1		 6ag0A-3axiA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 543
ALA A 329
ALA A 331
ILE A 585
LEU A 378
 None
 1.21A 6aybA-3axiA:
undetectable		 6aybA-3axiA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3axi OLIGO-1,6-GLUCOSIDAS
E IMA1
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 347
ASP A 307
VAL A 308
ALA A 277
 None
 1.24A 6djzB-3axiA:
undetectable		 6djzB-3axiA:
19.41