SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ay5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.91A 2eikC-3ay5A:
4.9
2eikJ-3ay5A:
undetectable		 2eikC-3ay5A:
21.94
2eikJ-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.96A 2eilP-3ay5A:
4.8
2eilW-3ay5A:
undetectable		 2eilP-3ay5A:
21.94
2eilW-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 245
ILE A 241
ILE A 295
ALA A 292
 None
 0.77A 2i2zA-3ay5A:
undetectable		 2i2zA-3ay5A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 VAL A 195
GLU A 192
GLU A 196
 None
 0.79A 2nv4A-3ay5A:
undetectable		 2nv4A-3ay5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A  18
PRO A  17
LEU A  21
 None
 0.63A 2po5B-3ay5A:
undetectable		 2po5B-3ay5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.97A 3ablP-3ay5A:
3.7
3ablW-3ay5A:
undetectable		 3ablP-3ay5A:
21.94
3ablW-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 1.01A 3ag2P-3ay5A:
4.8
3ag2W-3ay5A:
undetectable		 3ag2P-3ay5A:
21.94
3ag2W-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.94A 3asnC-3ay5A:
5.4
3asnJ-3ay5A:
undetectable		 3asnC-3ay5A:
21.94
3asnJ-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.95A 3asoC-3ay5A:
4.8
3asoJ-3ay5A:
undetectable		 3asoC-3ay5A:
21.94
3asoJ-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A  20
PHE A  74
PRO A  80
LEU A  70
 None
 1.40A 3tgvD-3ay5A:
undetectable		 3tgvD-3ay5A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 172
ALA A 121
LEU A 106
GLY A 111
GLN A 110
 None
 1.14A 4r38C-3ay5A:
undetectable		 4r38C-3ay5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 172
ALA A 121
LEU A 106
GLY A 111
GLN A 110
 None
 1.11A 4r38D-3ay5A:
undetectable		 4r38D-3ay5A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.97A 5b1aC-3ay5A:
4.9
5b1aJ-3ay5A:
undetectable		 5b1aC-3ay5A:
21.94
5b1aJ-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PRO A  17
LEU A  77
SER A  81
 None
 0.69A 5fsaB-3ay5A:
undetectable		 5fsaB-3ay5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 1.02A 5z84P-3ay5A:
3.7
5z84W-3ay5A:
undetectable		 5z84P-3ay5A:
21.94
5z84W-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 1.02A 5z85P-3ay5A:
3.7
5z85W-3ay5A:
undetectable		 5z85P-3ay5A:
21.94
5z85W-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.98A 5z86C-3ay5A:
4.9
5z86J-3ay5A:
undetectable		 5z86C-3ay5A:
21.94
5z86J-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 1.01A 5z86P-3ay5A:
3.7
5z86W-3ay5A:
undetectable		 5z86P-3ay5A:
21.94
5z86W-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 1.04A 5zcoP-3ay5A:
3.0
5zcoW-3ay5A:
undetectable		 5zcoP-3ay5A:
21.94
5zcoW-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.98A 5zcpC-3ay5A:
4.9
5zcpJ-3ay5A:
undetectable		 5zcpC-3ay5A:
21.94
5zcpJ-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 1.05A 5zcpP-3ay5A:
3.7
5zcpW-3ay5A:
undetectable		 5zcpP-3ay5A:
21.94
5zcpW-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ay5 CYCLIN-D1-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.98A 5zcqC-3ay5A:
4.9
5zcqJ-3ay5A:
undetectable		 5zcqC-3ay5A:
21.94
5zcqJ-3ay5A:
11.36