SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ayh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe)
4 / 7 MET B 113
SER B 156
ALA B 189
ILE B 188
None
1.05A 1fxhA-3ayhB:
undetectable
1fxhB-3ayhB:
undetectable
1fxhA-3ayhB:
20.26
1fxhB-3ayhB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe)
4 / 8 MET B 113
SER B 156
ALA B 189
ILE B 188
None
1.14A 1gm7A-3ayhB:
undetectable
1gm7B-3ayhB:
undetectable
1gm7A-3ayhB:
20.26
1gm7B-3ayhB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9

(Schizosaccharomy
ces
pombe)
5 / 11 ASN A  93
LEU A  82
GLU A  86
ARG A 111
PHE A 112
None
1.06A 1l5rA-3ayhA:
undetectable
1l5rA-3ayhA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9

(Schizosaccharomy
ces
pombe)
4 / 6 PHE B   2
VAL A  16
LEU A  20
SER A  58
None
0.81A 1wrlB-3ayhB:
undetectable
1wrlB-3ayhB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9

(Schizosaccharomy
ces
pombe)
4 / 8 ILE A  90
ARG A 111
LEU A  82
GLU A  86
None
0.98A 2cdqA-3ayhA:
undetectable
2cdqA-3ayhA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9

(Schizosaccharomy
ces
pombe)
4 / 6 PRO B  79
ILE B 101
ASN A  13
LEU A  56
None
1.38A 2wekB-3ayhB:
undetectable
2wekB-3ayhB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe)
3 / 3 GLU B  28
GLU B  24
TRP B  19
None
1.24A 3hrdA-3ayhB:
undetectable
3hrdE-3ayhB:
undetectable
3hrdF-3ayhB:
undetectable
3hrdA-3ayhB:
17.18
3hrdE-3ayhB:
17.18
3hrdF-3ayhB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe)
3 / 3 GLU B  94
GLU B  95
TRP B 127
None
0.96A 3hrdA-3ayhB:
undetectable
3hrdE-3ayhB:
undetectable
3hrdF-3ayhB:
undetectable
3hrdA-3ayhB:
17.18
3hrdE-3ayhB:
17.18
3hrdF-3ayhB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe)
5 / 12 ILE B  39
VAL B  38
ALA B  45
LEU B  44
ILE B 154
None
0.99A 3mb5A-3ayhB:
undetectable
3mb5A-3ayhB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
3 / 3 THR A  47
ASN B  36
GLU A  51
None
0.77A 3v4tA-3ayhA:
undetectable
3v4tC-3ayhA:
undetectable
3v4tA-3ayhA:
15.25
3v4tC-3ayhA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 6 ASN A  13
LEU A  88
GLU B  83
TYR A  55
None
1.46A 4wcxC-3ayhA:
undetectable
4wcxC-3ayhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe)
4 / 5 ALA B  27
ARG A  30
HIS A  19
GLU A  26
None
0.77A 5a06C-3ayhB:
undetectable
5a06D-3ayhB:
undetectable
5a06C-3ayhB:
19.94
5a06D-3ayhB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomy
ces
pombe)
4 / 5 ARG B 125
ALA B 126
TYR B 143
ILE B  89
None
1.37A 6f6sA-3ayhB:
undetectable
6f6sB-3ayhB:
undetectable
6f6sA-3ayhB:
16.83
6f6sB-3ayhB:
16.85