SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ayn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 6 ALA A 167
TYR A 177
ILE A 168
ILE A 117
 None
 1.20A 2dcfA-3aynA:
undetectable		 2dcfA-3aynA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		3 / 3 ASP A  80
ASN A  52
THR A  60
 None
None
PLM  A1001 ( 4.6A)
 0.59A 2pymB-3aynA:
undetectable		 2pymB-3aynA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		3 / 3 ASP A  80
ASN A  52
THR A  60
 None
None
PLM  A1001 ( 4.6A)
 0.63A 2q63B-3aynA:
undetectable		 2q63B-3aynA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 5 PHE A 188
PHE A 270
SER A  79
PHE A 205
 RET  A1000 (-4.5A)
None
None
RET  A1000 ( 3.8A)
 1.33A 2v0mD-3aynA:
undetectable		 2v0mD-3aynA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 8 TYR A 134
ASN A 222
GLY A 138
PRO A 140
 None
 0.82A 2ys6A-3aynA:
undetectable		 2ys6A-3aynA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 7 ALA A 167
TYR A 177
ILE A 168
ILE A 117
 None
 1.18A 2zm7A-3aynA:
undetectable		 2zm7A-3aynA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 5 TYR A 134
ALA A 260
ALA A 127
MET A 155
 None
 1.19A 3d91A-3aynA:
undetectable		 3d91A-3aynA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 8 ILE A 216
ILE A 266
PHE A 270
GLY A 119
 None
None
None
RET  A1000 ( 3.8A)
 0.75A 4hdlA-3aynA:
undetectable		 4hdlA-3aynA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		3 / 3 HIS A  20
TRP A  12
SER A 192
 None
 1.09A 4lrhD-3aynA:
undetectable		 4lrhD-3aynA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 5 ILE A 314
PHE A  72
SER A 316
ASP A  80
 None
 1.37A 4rzvB-3aynA:
2.1		 4rzvB-3aynA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		5 / 12 HIS A 319
ASN A  70
PRO A 312
VAL A  55
ILE A  74
 None
 1.49A 4v2gB-3aynA:
2.2		 4v2gB-3aynA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		5 / 12 SER A 263
ILE A 266
ILE A 129
ALA A  69
THR A  67
 None
 1.04A 5vceA-3aynA:
undetectable		 5vceA-3aynA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 7 ILE A 314
ARG A 133
MET A 126
LEU A  76
 None
 0.98A 5xdxA-3aynA:
6.8
5xdxJ-3aynA:
undetectable		 5xdxA-3aynA:
20.40
5xdxJ-3aynA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3ayn RHODOPSIN
(Todarodes
pacificus) 		4 / 6 TRP A 274
MET A  92
GLY A  45
ALA A 306
 RET  A1000 (-4.2A)
None
None
None
 1.09A 6fosA-3aynA:
3.1		 6fosA-3aynA:
12.37