SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ayr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 12 THR A  22
ALA A  25
ASP A  24
TRP A  87
LEU A  31
 None
 1.19A 1errA-3ayrA:
undetectable		 1errA-3ayrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		4 / 6 TRP A 164
TYR A 234
GLU A 154
GLY A 241
 None
 1.06A 1maaB-3ayrA:
0.5
1maaD-3ayrA:
undetectable		 1maaB-3ayrA:
20.80
1maaD-3ayrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		3 / 3 ILE A  10
ILE A 148
LEU A 348
 None
 0.42A 2prgA-3ayrA:
undetectable		 2prgA-3ayrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 12 LEU A 325
LEU A 342
ILE A 309
GLU A 278
PHE A  62
 None
 1.23A 2weyA-3ayrA:
undetectable		 2weyA-3ayrA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 11 PHE A 182
SER A 227
LEU A 107
PHE A 149
ILE A 136
 None
 1.28A 3ko0A-3ayrA:
undetectable
3ko0B-3ayrA:
undetectable
3ko0C-3ayrA:
undetectable
3ko0D-3ayrA:
undetectable		 3ko0A-3ayrA:
14.80
3ko0B-3ayrA:
14.80
3ko0C-3ayrA:
14.80
3ko0D-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 11 LEU A 107
PHE A 149
ILE A 136
PHE A 182
SER A 227
 None
 1.31A 3ko0C-3ayrA:
undetectable
3ko0D-3ayrA:
undetectable
3ko0E-3ayrA:
undetectable
3ko0F-3ayrA:
undetectable		 3ko0C-3ayrA:
14.80
3ko0D-3ayrA:
14.80
3ko0E-3ayrA:
14.80
3ko0F-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 11 SER A 227
PHE A 182
LEU A 107
PHE A 149
ILE A 136
 None
 1.29A 3ko0C-3ayrA:
undetectable
3ko0D-3ayrA:
undetectable
3ko0E-3ayrA:
undetectable
3ko0F-3ayrA:
undetectable		 3ko0C-3ayrA:
14.80
3ko0D-3ayrA:
14.80
3ko0E-3ayrA:
14.80
3ko0F-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 12 LEU A 107
PHE A 149
ILE A 136
PHE A 182
SER A 227
 None
 1.29A 3ko0G-3ayrA:
undetectable
3ko0H-3ayrA:
undetectable
3ko0I-3ayrA:
undetectable
3ko0J-3ayrA:
undetectable		 3ko0G-3ayrA:
14.80
3ko0H-3ayrA:
14.80
3ko0I-3ayrA:
14.80
3ko0J-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 11 SER A 227
PHE A 182
LEU A 107
PHE A 149
ILE A 136
 None
 1.30A 3ko0K-3ayrA:
undetectable
3ko0L-3ayrA:
undetectable
3ko0M-3ayrA:
undetectable
3ko0N-3ayrA:
undetectable		 3ko0K-3ayrA:
14.80
3ko0L-3ayrA:
14.80
3ko0M-3ayrA:
14.80
3ko0N-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 11 LEU A 107
PHE A 149
ILE A 136
PHE A 182
SER A 227
 None
 1.32A 3ko0O-3ayrA:
undetectable
3ko0P-3ayrA:
undetectable
3ko0Q-3ayrA:
undetectable
3ko0R-3ayrA:
undetectable		 3ko0O-3ayrA:
14.80
3ko0P-3ayrA:
14.80
3ko0Q-3ayrA:
14.80
3ko0R-3ayrA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 9 LEU A 325
ILE A 356
ALA A 355
ALA A 340
THR A 337
 None
 1.30A 3mdtA-3ayrA:
undetectable		 3mdtA-3ayrA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 9 LEU A 107
GLY A 277
ILE A 309
PRO A  68
THR A  69
 None
 1.26A 3spkA-3ayrA:
undetectable		 3spkA-3ayrA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		3 / 3 ARG A 290
ARG A 284
ILE A 338
 None
 0.87A 4b7qC-3ayrA:
undetectable		 4b7qC-3ayrA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		4 / 6 ILE A 225
PRO A 273
PHE A 217
PHE A 215
 None
 1.15A 4fgkA-3ayrA:
undetectable		 4fgkA-3ayrA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		4 / 6 ASP A  -1
ASP A 142
ASN A 193
ARG A 196
 None
 1.11A 4ntxA-3ayrA:
undetectable
4ntxC-3ayrA:
undetectable		 4ntxA-3ayrA:
20.70
4ntxC-3ayrA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		4 / 6 ILE A 275
ARG A  66
GLY A  16
HIS A 229
 None
 1.08A 4oltB-3ayrA:
undetectable		 4oltB-3ayrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 9 VAL A  95
VAL A  91
ILE A 136
PHE A 149
LEU A 147
 None
 1.39A 5e4dA-3ayrA:
undetectable		 5e4dA-3ayrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 12 GLU A  12
GLY A 102
ASN A  63
VAL A  95
TYR A  99
 None
 1.22A 5kbwB-3ayrA:
undetectable		 5kbwB-3ayrA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		4 / 8 PHE A  62
ARG A 346
GLN A 343
GLY A 345
 None
 0.95A 5nzxA-3ayrA:
1.5		 5nzxA-3ayrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		3 / 3 LYS A  -7
HIS A  -6
HIS A  -7
 None
 1.17A 5oexA-3ayrA:
undetectable		 5oexA-3ayrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		3 / 3 LYS A  -7
HIS A  -6
HIS A  -7
 None
 1.12A 5oexB-3ayrA:
undetectable		 5oexB-3ayrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		3 / 3 LYS A  -7
HIS A  -6
HIS A  -7
 None
 1.12A 5oexC-3ayrA:
undetectable		 5oexC-3ayrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		3 / 3 LYS A  -7
HIS A  -6
HIS A  -7
 None
 1.14A 5oexD-3ayrA:
undetectable		 5oexD-3ayrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		4 / 6 PHE A 104
GLY A 102
ASN A 101
LYS A 100
 None
 0.97A 5x24A-3ayrA:
undetectable		 5x24A-3ayrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		3 / 3 GLU A 154
TRP A 164
HIS A 111
 None
 1.01A 5xipA-3ayrA:
undetectable		 5xipA-3ayrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3ayr ENDOGLUCANASE
(Piromyces
rhizinflatus) 		5 / 12 PHE A 323
GLY A 280
ILE A 333
LEU A 326
GLY A 324
 None
 0.80A 6c2mA-3ayrA:
undetectable		 6c2mA-3ayrA:
13.39