SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ayt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		4 / 4 LEU A  56
PRO A  57
LEU A  78
ARG A 125
 None
 1.29A 1hrkB-3aytA:
undetectable		 1hrkB-3aytA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		3 / 3 GLU A 136
HIS A 165
HIS A  96
 ZN  A 255 ( 2.2A)
ZN  A 257 ( 3.4A)
ZN  A 255 (-3.5A)
 0.60A 1oe2A-3aytA:
undetectable		 1oe2A-3aytA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		3 / 3 ASP A 174
THR A 172
GLU A 144
 None
 0.83A 1pj7A-3aytA:
undetectable		 1pj7A-3aytA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		4 / 4 LEU A  56
PRO A  57
LEU A  78
ARG A 125
 None
 1.28A 2hrcB-3aytA:
undetectable		 2hrcB-3aytA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		4 / 4 LEU A  56
PRO A  57
LEU A  78
ARG A 125
 None
 1.30A 2pnjB-3aytA:
undetectable		 2pnjB-3aytA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		4 / 4 LEU A  56
PRO A  57
LEU A  78
ARG A 125
 None
 1.38A 2qd2A-3aytA:
undetectable		 2qd2A-3aytA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		4 / 8 TYR A 215
LEU A 212
LEU A 186
ALA A 163
 None
 0.92A 2wekA-3aytA:
undetectable		 2wekA-3aytA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 10 ALA A 237
ALA A 233
LEU A 222
MET A 220
VAL A   3
 None
 1.27A 2wuzA-3aytA:
undetectable		 2wuzA-3aytA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 10 ALA A 237
ALA A 233
LEU A 222
MET A 220
VAL A   3
 None
 1.27A 2wuzB-3aytA:
undetectable		 2wuzB-3aytA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 12 LEU A 181
GLY A  98
LEU A 157
LEU A 150
VAL A 149
 None
 0.98A 3adxB-3aytA:
undetectable		 3adxB-3aytA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		3 / 3 CYH A 160
PHE A 161
PHE A 159
 None
 1.08A 3cr5X-3aytA:
undetectable		 3cr5X-3aytA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 12 VAL A 168
SER A 170
ASN A 137
ASN A 189
LEU A 206
 None
 1.10A 4kukA-3aytA:
undetectable		 4kukA-3aytA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 12 VAL A 168
SER A 170
ASN A 137
ASN A 189
LEU A 206
 None
 1.03A 4kuoA-3aytA:
undetectable		 4kuoA-3aytA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 7 HIS A  55
HIS A 187
HIS A 165
ASN A 137
VAL A  94
 ZN  A 255 (-3.4A)
ZN  A 256 (-3.5A)
ZN  A 257 ( 3.4A)
None
None
 1.23A 4p6sA-3aytA:
undetectable		 4p6sA-3aytA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		4 / 5 LEU A  52
SER A  53
ASP A   2
ASP A 217
 None
 1.33A 4qtuD-3aytA:
undetectable		 4qtuD-3aytA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 7 HIS A  55
HIS A 187
HIS A 165
ASN A 137
VAL A  94
 ZN  A 255 (-3.4A)
ZN  A 256 (-3.5A)
ZN  A 257 ( 3.4A)
None
None
 1.21A 5i3bA-3aytA:
undetectable		 5i3bA-3aytA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		5 / 10 LEU A 206
ARG A 167
PRO A 173
ALA A 166
PHE A 161
 None
 1.30A 5m0oA-3aytA:
undetectable		 5m0oA-3aytA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		3 / 3 HIS A 165
ASP A 196
HIS A 198
 ZN  A 257 ( 3.4A)
ZN  A 257 (-3.0A)
ZN  A 257 (-3.8A)
 0.52A 5oexA-3aytA:
undetectable		 5oexA-3aytA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		3 / 3 HIS A 165
ASP A 196
HIS A 198
 ZN  A 257 ( 3.4A)
ZN  A 257 (-3.0A)
ZN  A 257 (-3.8A)
 0.57A 5oexB-3aytA:
undetectable		 5oexB-3aytA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		3 / 3 HIS A 165
ASP A 196
HIS A 198
 ZN  A 257 ( 3.4A)
ZN  A 257 (-3.0A)
ZN  A 257 (-3.8A)
 0.56A 5oexC-3aytA:
undetectable		 5oexC-3aytA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		3 / 3 HIS A 165
ASP A 196
HIS A 198
 ZN  A 257 ( 3.4A)
ZN  A 257 (-3.0A)
ZN  A 257 (-3.8A)
 0.55A 5oexD-3aytA:
undetectable		 5oexD-3aytA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071
(Thermus
thermophilus) 		4 / 4 LEU A   5
ASP A 227
PRO A 228
ARG A  18
 None
 1.42A 6fgdA-3aytA:
undetectable		 6fgdA-3aytA:
21.68