SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.19A 1c9sQ-3b05A:
undetectable
1c9sR-3b05A:
undetectable		 1c9sQ-3b05A:
13.61
1c9sR-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 VAL A 265
SER A 264
SER A 200
VAL A 192
LEU A 176
 None
 1.23A 1db1A-3b05A:
undetectable		 1db1A-3b05A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 SER A 273
GLY A 272
LEU A 270
GLY A 219
VAL A 265
 FNR  A 669 ( 4.5A)
None
None
None
None
 1.11A 1fduC-3b05A:
undetectable		 1fduC-3b05A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.49A 1fohA-3b05A:
undetectable		 1fohA-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.47A 1fohB-3b05A:
undetectable		 1fohB-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1fohC-3b05A:
undetectable		 1fohC-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1fohD-3b05A:
1.8		 1fohD-3b05A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.17A 1gtfD-3b05A:
undetectable
1gtfE-3b05A:
undetectable		 1gtfD-3b05A:
13.61
1gtfE-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.23A 1gtfR-3b05A:
undetectable
1gtfS-3b05A:
undetectable		 1gtfR-3b05A:
13.61
1gtfS-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1pn0C-3b05A:
1.6		 1pn0C-3b05A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 216
GLY A 272
MET A  63
VAL A 271
GLY A 274
 None
None
None
None
FNR  A 669 (-3.6A)
 1.46A 1pn0D-3b05A:
1.5		 1pn0D-3b05A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 11 ASP A 150
ARG A 114
VAL A  64
ILE A 191
PHE A  53
 None
 1.37A 1tcoC-3b05A:
undetectable		 1tcoC-3b05A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.16A 1utdE-3b05A:
undetectable
1utdF-3b05A:
undetectable		 1utdE-3b05A:
13.61
1utdF-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_H_TRPH81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.15A 1utdH-3b05A:
undetectable
1utdI-3b05A:
undetectable		 1utdH-3b05A:
13.61
1utdI-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 285
THR A  27
THR A 254
ILE A 258
GLY A 222
 None
None
None
None
FNR  A 669 (-3.4A)
 1.20A 1utdU-3b05A:
undetectable
1utdV-3b05A:
undetectable		 1utdU-3b05A:
13.61
1utdV-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 PHE A 269
ASP A 150
ILE A 147
GLY A  93
ILE A 123
 None
 1.30A 2e7fA-3b05A:
7.7		 2e7fA-3b05A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 ARG A 315
PHE A 314
ILE A  90
ILE A 120
ALA A 117
 None
 1.16A 2j0dA-3b05A:
undetectable		 2j0dA-3b05A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 GLU A  10
ILE A  14
GLU A 229
ILE A 228
ILE A 231
 None
 1.11A 2j9dA-3b05A:
0.0
2j9dB-3b05A:
0.0
2j9dC-3b05A:
0.0		 2j9dA-3b05A:
13.51
2j9dB-3b05A:
13.51
2j9dC-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 GLU A 229
ILE A 228
ILE A 231
GLU A  10
ILE A  14
 None
 1.09A 2j9dA-3b05A:
0.0
2j9dB-3b05A:
0.0
2j9dC-3b05A:
0.0		 2j9dA-3b05A:
13.51
2j9dB-3b05A:
13.51
2j9dC-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 GLU A  10
ILE A  14
GLU A 229
ILE A 228
ILE A 231
 None
 1.08A 2j9dG-3b05A:
0.0
2j9dH-3b05A:
0.0
2j9dI-3b05A:
0.0		 2j9dG-3b05A:
13.51
2j9dH-3b05A:
13.51
2j9dI-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 GLU A 229
ILE A 228
ILE A 231
GLU A  10
ILE A  14
 None
 1.09A 2j9dG-3b05A:
0.0
2j9dH-3b05A:
0.0
2j9dI-3b05A:
0.0		 2j9dG-3b05A:
13.51
2j9dH-3b05A:
13.51
2j9dI-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 ILE A 231
GLU A  10
ILE A  14
GLU A 229
ILE A 228
 None
 1.11A 2j9dG-3b05A:
0.0
2j9dH-3b05A:
0.0
2j9dI-3b05A:
0.0		 2j9dG-3b05A:
13.51
2j9dH-3b05A:
13.51
2j9dI-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 8 GLU A  10
ILE A  14
GLU A 229
ILE A 228
 None
 0.96A 2j9dJ-3b05A:
undetectable
2j9dK-3b05A:
undetectable
2j9dL-3b05A:
undetectable		 2j9dJ-3b05A:
13.51
2j9dK-3b05A:
13.51
2j9dL-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 8 GLU A 229
ILE A 228
ILE A 231
GLU A  10
 None
 0.98A 2j9dJ-3b05A:
undetectable
2j9dK-3b05A:
undetectable
2j9dL-3b05A:
undetectable		 2j9dJ-3b05A:
13.51
2j9dK-3b05A:
13.51
2j9dL-3b05A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 PHE A 269
ASP A 150
ILE A 147
GLY A  93
ILE A 123
 None
 1.32A 2ogyA-3b05A:
7.7		 2ogyA-3b05A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 PHE A 269
ASP A 150
ILE A 147
GLY A  93
ILE A 123
 None
 1.35A 2ogyB-3b05A:
7.6		 2ogyB-3b05A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 11 ASP A 150
ARG A 114
VAL A  64
ILE A 191
PHE A  53
 None
 1.24A 2vn1A-3b05A:
undetectable		 2vn1A-3b05A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 PHE A 269
ASP A 150
ILE A 147
GLY A  93
ILE A 123
 None
 1.31A 2ycjA-3b05A:
4.8		 2ycjA-3b05A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 VAL A 265
SER A 264
SER A 200
VAL A 192
LEU A 176
 None
 1.23A 2zlcA-3b05A:
undetectable		 2zlcA-3b05A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 5 ILE A 341
TYR A 361
ARG A 262
MET A 259
 None
 1.27A 3abkN-3b05A:
undetectable
3abkW-3b05A:
undetectable		 3abkN-3b05A:
22.18
3abkW-3b05A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ILE A  80
ILE A  81
VAL A  64
GLY A  93
VAL A  12
 None
None
None
None
FNR  A 669 ( 4.3A)
 1.29A 3em0A-3b05A:
undetectable		 3em0A-3b05A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 150
ARG A 114
VAL A  64
ILE A 191
PHE A  53
 None
 1.36A 3uqaA-3b05A:
undetectable		 3uqaA-3b05A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 11 ASP A 150
ARG A 114
VAL A  64
ILE A 191
PHE A  53
 None
 1.33A 3vawA-3b05A:
undetectable		 3vawA-3b05A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 VAL A 265
SER A 264
SER A 200
VAL A 192
LEU A 176
 None
 1.22A 3vt3A-3b05A:
undetectable		 3vt3A-3b05A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 150
ARG A 114
VAL A  64
ILE A 191
PHE A  53
 None
 1.42A 4dz3A-3b05A:
undetectable		 4dz3A-3b05A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ASP A 150
ARG A 114
VAL A  64
ILE A 191
PHE A  53
 None
 1.31A 4dz3B-3b05A:
undetectable		 4dz3B-3b05A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 GLY A 279
ILE A 276
ALA A 293
ARG A 277
PHE A 319
 None
None
None
FNR  A 669 (-2.8A)
None
 1.18A 4kicA-3b05A:
undetectable		 4kicA-3b05A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		6 / 12 ILE A  90
GLY A 279
ILE A 276
ALA A 293
ARG A 277
PHE A 319
 None
None
None
None
FNR  A 669 (-2.8A)
None
 1.30A 4kicB-3b05A:
undetectable		 4kicB-3b05A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 8 HIS A 155
ARG A  98
ASN A 125
ILE A 152
 IPE  A 701 ( 3.4A)
IPE  A 701 (-3.9A)
FNR  A 669 (-3.0A)
None
 1.01A 4l7iA-3b05A:
undetectable		 4l7iA-3b05A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 GLU A 202
ALA A 204
ARG A 354
ALA A 256
GLY A 198
 None
 1.10A 4oaeA-3b05A:
undetectable		 4oaeA-3b05A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 GLY A 272
GLY A 294
MET A 295
ILE A 286
ALA A 285
 None
 1.16A 4qtuD-3b05A:
undetectable		 4qtuD-3b05A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 GLY A 274
GLY A 219
GLY A 198
ALA A 282
ASP A 216
 FNR  A 669 (-3.6A)
None
None
None
None
 0.93A 5c0oF-3b05A:
undetectable		 5c0oF-3b05A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eevA-3b05A:
undetectable
5eevB-3b05A:
undetectable		 5eevA-3b05A:
13.61
5eevB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eewA-3b05A:
undetectable
5eewB-3b05A:
undetectable		 5eewA-3b05A:
13.61
5eewB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 283
ALA A 287
THR A 328
HIS A  36
ILE A 341
 None
 1.20A 5eewF-3b05A:
undetectable
5eewG-3b05A:
undetectable		 5eewF-3b05A:
13.61
5eewG-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eexA-3b05A:
undetectable
5eexB-3b05A:
undetectable		 5eexA-3b05A:
13.61
5eexB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eeyA-3b05A:
undetectable
5eeyB-3b05A:
undetectable		 5eeyA-3b05A:
13.61
5eeyB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 283
ALA A 287
THR A 328
HIS A  36
ILE A 341
 None
 1.20A 5eeyF-3b05A:
undetectable
5eeyG-3b05A:
undetectable		 5eeyF-3b05A:
13.61
5eeyG-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5eezA-3b05A:
undetectable
5eezB-3b05A:
undetectable		 5eezA-3b05A:
13.61
5eezB-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef0A-3b05A:
undetectable
5ef0B-3b05A:
undetectable		 5ef0A-3b05A:
13.61
5ef0B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 283
ALA A 287
THR A 328
HIS A  36
ILE A 341
 None
 1.19A 5ef0F-3b05A:
undetectable
5ef0G-3b05A:
undetectable		 5ef0F-3b05A:
13.61
5ef0G-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef1A-3b05A:
undetectable
5ef1B-3b05A:
undetectable		 5ef1A-3b05A:
13.61
5ef1B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 283
ALA A 287
THR A 328
HIS A  36
ILE A 341
 None
 1.20A 5ef1F-3b05A:
undetectable
5ef1G-3b05A:
undetectable		 5ef1F-3b05A:
13.61
5ef1G-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef2A-3b05A:
undetectable
5ef2B-3b05A:
undetectable		 5ef2A-3b05A:
13.61
5ef2B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 283
ALA A 287
THR A 328
HIS A  36
ILE A 341
 None
 1.20A 5ef2F-3b05A:
undetectable
5ef2G-3b05A:
undetectable		 5ef2F-3b05A:
13.61
5ef2G-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 GLY A 222
ALA A 285
THR A  27
THR A 254
ILE A 258
 FNR  A 669 (-3.4A)
None
None
None
None
 1.15A 5ef3A-3b05A:
undetectable
5ef3B-3b05A:
undetectable		 5ef3A-3b05A:
13.61
5ef3B-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 10 ALA A 283
ALA A 287
THR A 328
HIS A  36
ILE A 341
 None
 1.19A 5ef3F-3b05A:
undetectable
5ef3G-3b05A:
undetectable		 5ef3F-3b05A:
13.61
5ef3G-3b05A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		3 / 3 ILE A 123
MET A 128
ASP A 216
 None
 0.69A 5h2uA-3b05A:
undetectable		 5h2uA-3b05A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 PHE A  53
LEU A  29
ILE A 276
GLY A 294
MET A  63
 None
 1.11A 5ifuA-3b05A:
undetectable		 5ifuA-3b05A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 9 LEU A 176
ALA A 175
VAL A 192
HIS A 155
ILE A 212
 None
None
None
IPE  A 701 ( 3.4A)
None
 1.22A 5om2A-3b05A:
undetectable
5om2B-3b05A:
undetectable		 5om2A-3b05A:
11.17
5om2B-3b05A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A  29
ALA A 290
ARG A 277
PRO A  61
LEU A 321
 None
None
FNR  A 669 (-2.8A)
None
None
 1.38A 5syfB-3b05A:
2.7		 5syfB-3b05A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 VAL A 265
ARG A 354
TYR A 208
SER A 209
GLU A 202
 None
 1.48A 5v1tA-3b05A:
5.3		 5v1tA-3b05A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 GLY A 294
VAL A  32
LEU A  34
GLY A 289
ILE A 258
 None
 1.08A 5vooE-3b05A:
6.9		 5vooE-3b05A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 ALA A 293
GLY A 294
SER A 273
LEU A 336
ARG A 277
 None
None
FNR  A 669 ( 4.5A)
None
FNR  A 669 (-2.8A)
 1.16A 5w7pA-3b05A:
undetectable		 5w7pA-3b05A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		3 / 3 ARG A   7
LYS A 133
ARG A 232
 IPE  A 701 (-3.9A)
None
None
 1.38A 6az3C-3b05A:
undetectable
6az3L-3b05A:
undetectable
6az3M-3b05A:
undetectable		 6az3C-3b05A:
12.46
6az3L-3b05A:
12.53
6az3M-3b05A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		5 / 12 LEU A 176
LEU A 156
SER A 257
ILE A 199
VAL A 261
 None
 1.26A 6debB-3b05A:
undetectable		 6debB-3b05A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
(Sulfolobus
shibatae) 		4 / 6 LEU A  29
THR A  27
GLY A 221
ARG A 277
 None
None
None
FNR  A 669 (-2.8A)
 1.36A 6gtqB-3b05A:
undetectable
6gtqD-3b05A:
undetectable		 6gtqB-3b05A:
18.48
6gtqD-3b05A:
9.09