SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 GLY A 104
ASN A  90
GLY A  92
VAL A  12
 None
FMN  A 351 (-4.0A)
None
FMN  A 351 (-4.0A)
 0.73A 1dbbH-3b0pA:
undetectable
1dbbL-3b0pA:
undetectable		 1dbbH-3b0pA:
22.22
1dbbL-3b0pA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 5 ASP A  39
LEU A  51
ALA A  76
LEU A  72
 None
 1.01A 1nh8A-3b0pA:
undetectable		 1nh8A-3b0pA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 ASP A 306
LEU A 309
HIS A  18
 None
 0.76A 1qknA-3b0pA:
undetectable		 1qknA-3b0pA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 7 ARG A 134
ALA A  65
ASP A  39
GLY A 101
 None
 0.83A 2fxdB-3b0pA:
undetectable		 2fxdB-3b0pA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		3 / 3 ALA A  65
GLY A 101
SER A  95
 None
 0.54A 2ivuA-3b0pA:
3.9		 2ivuA-3b0pA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 HIS A 278
GLU A  57
ASP A  16
GLU A  48
 None
 1.31A 3vywA-3b0pA:
undetectable		 3vywA-3b0pA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 8 ASP A 186
TRP A 187
VAL A 219
LEU A 135
 None
 1.09A 4f5zA-3b0pA:
undetectable		 4f5zA-3b0pA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 5 GLY A 225
ILE A 206
LEU A   6
LEU A  22
 FMN  A 351 (-3.5A)
None
None
None
 0.86A 4o8fA-3b0pA:
undetectable		 4o8fA-3b0pA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 VAL A 158
LEU A  72
ILE A 117
LEU A 118
GLY A 157
 None
 1.19A 5ienA-3b0pA:
undetectable		 5ienA-3b0pA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		5 / 10 LEU A 224
ILE A 206
GLY A 204
LEU A   6
VAL A 222
 None
None
FMN  A 351 (-3.7A)
None
None
 1.15A 5twjB-3b0pA:
undetectable		 5twjB-3b0pA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A 224
ILE A 206
GLY A 204
LEU A   6
VAL A 222
 None
None
FMN  A 351 (-3.7A)
None
None
 1.13A 5twjC-3b0pA:
undetectable		 5twjC-3b0pA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 GLY A 136
LEU A 135
VAL A 114
PHE A 161
 None
 0.74A 6h7lA-3b0pA:
undetectable		 6h7lA-3b0pA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3b0p TRNA-DIHYDROURIDINE
SYNTHASE
(Thermus
thermophilus) 		4 / 6 GLY A 136
LEU A 135
VAL A 114
PHE A 161
 None
 0.74A 6h7lB-3b0pA:
undetectable		 6h7lB-3b0pA:
13.33