SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3b1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 6 PHE A 215
PHE A 225
GLU A 183
GLY A 186
 None
 1.13A 1icuA-3b1eA:
undetectable
1icuB-3b1eA:
undetectable		 1icuA-3b1eA:
20.10
1icuB-3b1eA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 6 PHE A 225
GLU A 183
GLY A 186
PHE A 215
 None
 1.08A 1icuA-3b1eA:
undetectable
1icuB-3b1eA:
undetectable		 1icuA-3b1eA:
20.10
1icuB-3b1eA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 6 PHE A 215
PHE A 225
GLU A 183
GLY A 186
 None
 1.15A 1icuC-3b1eA:
undetectable
1icuD-3b1eA:
undetectable		 1icuC-3b1eA:
20.10
1icuD-3b1eA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 6 PHE A 215
PHE A 225
GLU A 183
GLY A 186
 None
 1.12A 1kqbA-3b1eA:
undetectable
1kqbB-3b1eA:
undetectable		 1kqbA-3b1eA:
20.61
1kqbB-3b1eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 6 PHE A 215
PHE A 225
GLU A 183
GLY A 186
 None
 1.12A 1kqbC-3b1eA:
undetectable
1kqbD-3b1eA:
undetectable		 1kqbC-3b1eA:
20.61
1kqbD-3b1eA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		3 / 3 THR A  25
THR A  23
PRO A  27
 None
 0.85A 1qfiB-3b1eA:
undetectable		 1qfiB-3b1eA:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 LEU A 229
LEU A 227
LEU A 253
GLN A 256
LEU A 165
 None
 1.50A 1sqnA-3b1eA:
undetectable		 1sqnA-3b1eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 7 LEU A 313
VAL A 383
VAL A 348
ILE A 378
 None
 0.98A 1t87B-3b1eA:
undetectable		 1t87B-3b1eA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 11 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
0JO  A 401 ( 3.7A)
0JO  A 401 (-2.8A)
None
 1.23A 2a5hA-3b1eA:
2.1		 2a5hA-3b1eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
0JO  A 401 ( 3.7A)
0JO  A 401 (-2.8A)
None
 1.24A 2a5hB-3b1eA:
2.0		 2a5hB-3b1eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
0JO  A 401 ( 3.7A)
0JO  A 401 (-2.8A)
None
 1.25A 2a5hC-3b1eA:
2.1		 2a5hC-3b1eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 HIS A 170
VAL A 118
TYR A 119
ASP A 199
LEU A 166
 None
None
0JO  A 401 ( 3.7A)
0JO  A 401 (-2.8A)
None
 1.24A 2a5hD-3b1eA:
2.0		 2a5hD-3b1eA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 LEU A 229
LEU A 253
GLN A 256
LEU A 165
VAL A 263
 None
 1.36A 2w8yA-3b1eA:
undetectable		 2w8yA-3b1eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 6 ASP A  87
TYR A 245
PHE A 257
LEU A 229
 None
 0.89A 2w98A-3b1eA:
3.2
2w98B-3b1eA:
2.9		 2w98A-3b1eA:
20.67
2w98B-3b1eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 8 LEU A 366
TYR A 331
PHE A 328
PHE A 306
 None
 0.98A 2weyB-3b1eA:
undetectable		 2weyB-3b1eA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_A_PXLA1503_1
(ASPARTATE
AMINOTRANSFERASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 10 VAL A  95
TYR A 119
CYH A 167
ASP A 199
LYS A 234
 0JO  A 401 ( 3.8A)
0JO  A 401 ( 3.7A)
0JO  A 401 (-3.3A)
0JO  A 401 (-2.8A)
0JO  A 401 (-2.8A)
 1.14A 2z9xA-3b1eA:
22.8		 2z9xA-3b1eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9X_B_PXLB2503_1
(ASPARTATE
AMINOTRANSFERASE)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 11 VAL A  95
TYR A 119
CYH A 167
ASP A 199
LYS A 234
 0JO  A 401 ( 3.8A)
0JO  A 401 ( 3.7A)
0JO  A 401 (-3.3A)
0JO  A 401 (-2.8A)
0JO  A 401 (-2.8A)
 1.14A 2z9xB-3b1eA:
23.1		 2z9xB-3b1eA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 LEU A 229
LEU A 227
LEU A 253
GLN A 256
LEU A 165
 None
 1.42A 3d90A-3b1eA:
undetectable		 3d90A-3b1eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 LEU A 366
ALA A   9
ILE A 299
LEU A 205
GLY A 320
 None
 1.17A 4l9qB-3b1eA:
undetectable		 4l9qB-3b1eA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 7 THR A 206
LEU A 207
THR A 235
LEU A 291
 None
 0.94A 4z91F-3b1eA:
undetectable
4z91G-3b1eA:
undetectable
4z91H-3b1eA:
undetectable
4z91I-3b1eA:
undetectable
4z91J-3b1eA:
undetectable		 4z91F-3b1eA:
21.84
4z91G-3b1eA:
21.84
4z91H-3b1eA:
21.84
4z91I-3b1eA:
21.84
4z91J-3b1eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		5 / 12 PRO A 117
GLY A 174
LEU A 144
ASN A 171
GLU A 140
 None
None
None
0JO  A 401 (-3.6A)
None
 1.48A 5emlA-3b1eA:
undetectable		 5emlA-3b1eA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		3 / 3 TYR A 322
TYR A 281
SER A 230
 None
 0.99A 5iktB-3b1eA:
undetectable		 5iktB-3b1eA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 8 ASN A 250
PRO A 251
GLU A  86
TYR A  81
 None
None
EPE  A 503 (-3.8A)
None
 1.19A 5oh1C-3b1eA:
undetectable		 5oh1C-3b1eA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		3 / 3 ARG A 365
PHE A 301
LEU A 295
 0JO  A 401 (-2.7A)
None
None
 0.85A 5veuA-3b1eA:
undetectable		 5veuA-3b1eA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 7 GLY A 174
TYR A 164
TRP A 177
TYR A 356
 None
 1.23A 5vlmG-3b1eA:
undetectable		 5vlmG-3b1eA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_2
(-)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 6 TYR A 164
HIS A 170
ASN A 168
GLU A 178
 None
 1.46A 6gneA-3b1eA:
undetectable		 6gneA-3b1eA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3b1e BETAC-S LYASE
(Streptococcus
anginosus) 		4 / 5 GLU A 278
ASP A  65
ASN A 243
TYR A  62
 None
 1.47A 6iftA-3b1eA:
2.8		 6iftA-3b1eA:
21.59